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Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. |
2007 |
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PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. |
2007 |
Am. J. Physiol. Endocrinol. Metab. |
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Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. |
2007 |
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Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. |
2007 |
Pulm Pharmacol Ther |
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In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. |
2007 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages. |
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Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. |
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Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). |
2007 |
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Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement. |
2007 |
Biochemistry |
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Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. |
2007 |
Nat Rev Drug Discov |
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Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. |
2007 |
Ann. N. Y. Acad. Sci. |
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Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. |
2007 |
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Putative mechanism of the itch-scratch circle: repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching. |
2007 |
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Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. |
2007 |
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The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. |
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Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. |
2007 |
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Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. |
2007 |
J. Pharmacol. Exp. Ther. |
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The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. |
2007 |
Gastroenterology |
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Involvement of PPARgamma in human trophoblast invasion. |
2007 |
Placenta |
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Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
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Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. |
2007 |
Cytokine |
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2007 |
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[15-deoxy-Delta(12,14)-prostaglandin J(2) induces anoikis of hepatocellular carcinoma cells: an in vitro experiment]. |
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Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. |
2007 |
Neuropsychopharmacology |
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Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. |
2006 Sep-Oct |
J. Gastrointest. Surg. |
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The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. |
2006 Sep-Oct |
J. Diabetes Complicat. |
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Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. |
2006 Oct-Dec |
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15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. |
2006 Nov-Dec |
Placenta |
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Twenty-fifth anniversary of the discovery of somnogenic activity of prostaglandin D2: sleep research directed by Osamu Hayaishi. |
2006 May-Jun |
IUBMB Life |
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Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis. |
2006 May-Jun |
Am J Rhinol |
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Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. |
2006 May-Jun |
Allergy Asthma Proc |
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Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
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[Role of cutaneous prostaglandin D2 production on scratching dermatitis in mice]. |
2006 |
Nippon Yakurigaku Zasshi |
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Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. |
2006 |
Allergol Int |
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Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. |
2006 |
Allergol Int |
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Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. |
2006 |
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[The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)]. |
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15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism. |
2006 |
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15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. |
2006 |
Mol. Cancer Ther. |
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Wang XS and Lau HY |
Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells. |
2006 |
Clin. Exp. Pharmacol. Physiol. |
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Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephosphorylation. |
2006 |
Mol. Pharmacol. |
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Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. |
2006 |
Mol. Pharmacol. |
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Arnold R and König W |
Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. |
2006 |
Virology |
pmid:16616290
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Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
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Cross metathesis as a general strategy for the synthesis of prostacyclin and prostaglandin analogues. |
2006 |
Org. Lett. |
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Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. |
2006 |
Eur. J. Pharmacol. |
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Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice. |
2006 |
Exp. Dermatol. |
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Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. |
2006 |
Immunol. Lett. |
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ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. |
2006 |
Genes Cells |
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Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates. |
2006 |
J. Biol. Chem. |
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Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. |
2006 |
Int. Immunopharmacol. |
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A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. |
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Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. |
2006 |
J. Cell. Biochem. |
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Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. |
2006 |
Cell. Signal. |
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Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. |
2006 |
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Peroxisome proliferator-activated receptors and acute lung injury. |
2006 |
Curr Opin Pharmacol |
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Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing. |
2006 |
Eur. Respir. J. |
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Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions. |
2006 |
Endocr. Relat. Cancer |
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Systemic inflammation induces COX-2 mediated prostaglandin D2 biosynthesis in mice spinal cord. |
2006 |
Neuropharmacology |
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15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. |
2006 |
J. Cereb. Blood Flow Metab. |
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[The role of peroxisome proliferator-activated receptor gamma in proliferation of cardiac non myocytes]. |
2006 |
Zhongguo Ying Yong Sheng Li Xue Za Zhi |
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Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. |
2006 |
J. Neuroimmunol. |
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Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. |
2006 |
Biochem. J. |
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15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. |
2006 |
Neurochem. Res. |
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Langerhans cells release prostaglandin D2 in response to nicotinic acid. |
2006 |
J. Invest. Dermatol. |
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GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. |
2006 |
Br. J. Pharmacol. |
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Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. |
2006 |
Carcinogenesis |
pmid:16113051
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Gulliksson M et al. |
Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. |
2006 |
Allergy |
pmid:17073880
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Phulwani NK et al. |
15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. |
2006 |
J. Neurochem. |
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Kim EH et al. |
Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. |
2006 |
Ann. N. Y. Acad. Sci. |
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Aquila S et al. |
Peroxisome proliferator-activated receptor (PPAR)gamma is expressed by human spermatozoa: its potential role on the sperm physiology. |
2006 |
J. Cell. Physiol. |
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Addition of electrophilic lipids to actin alters filament structure. |
2006 |
Biochem. Biophys. Res. Commun. |
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Zhang YJ et al. |
Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). |
2006 |
Am. J. Nephrol. |
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Schratl P et al. |
Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase. |
2006 |
Eur. J. Immunol. |
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Ciucci A et al. |
Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. |
2006 |
Mol. Pharmacol. |
pmid:16908599
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Egan K and FitzGerald GA |
Eicosanoids and the vascular endothelium. |
2006 |
Handb Exp Pharmacol |
pmid:16999220
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Sugimoto M et al. |
Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice. |
2006 |
Exp. Dermatol. |
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Feldon SE et al. |
Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. |
2006 |
Am. J. Pathol. |
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Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. |
2006 |
Pflugers Arch. |
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Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. |
2006 |
Anticancer Drugs |
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Satoh T et al. |
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. |
2006 |
J. Immunol. |
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Sugimoto M et al. |
COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis. |
2006 |
Exp. Dermatol. |
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Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis. |
2006 |
Gene |
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PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. |
2006 |
J. Neuroimmunol. |
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15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16939878
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Lim HJ et al. |
PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16939881
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Chiba T et al. |
Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway. |
2006 |
Int. Arch. Allergy Immunol. |
pmid:16940740
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Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. |
2006 |
J. Immunol. |
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MartÃn AR et al. |
The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. |
2006 |
Br. J. Pharmacol. |
pmid:16474422
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Kang HY et al. |
Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. |
2006 |
Arch. Dermatol. Res. |
pmid:16474974
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15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. |
2006 |
J. Lipid Res. |
pmid:16495511
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King VL et al. |
Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. |
2006 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:16514081
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Ray DM et al. |
The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. |
2006 |
J. Immunol. |
pmid:17015690
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Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. |
2006 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16876988
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Piraino G et al. |
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
Shock |
pmid:16878022
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Moulin D et al. |
Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. |
2006 |
Biorheology |
pmid:16912428
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Yeh CH et al. |
Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. |
2006 |
Shock |
pmid:16912651
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Ye F et al. |
Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. |
2006 |
Cell. Physiol. Biochem. |
pmid:16914899
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Lee JJ et al. |
Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. |
2006 |
Vascul. Pharmacol. |
pmid:16916624
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Ulven T and Kostenis E |
Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation. |
2006 |
Curr Top Med Chem |
pmid:16918458
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