| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hata AN et al. | Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. | 2005 | Mol. Pharmacol. | pmid:15563582 |
| Nie M et al. | Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. | 2005 | J. Biol. Chem. | pmid:15531761 |
| Kobayashi Y et al. | Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. | 2005 | J. Immunol. | pmid:16237065 |
| Na HK et al. | ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. | 2005 | FEBS Lett. | pmid:16253239 |
| Sugimoto H et al. | CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. | 2005 | Eur. J. Pharmacol. | pmid:16256979 |
| Choi YH et al. | New anti-inflammatory formulation containing Synurus deltoides extract. | 2005 | Arch. Pharm. Res. | pmid:16114500 |
| Kim KA et al. | 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16098720 |
| Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
| Artwohl M et al. | Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. | 2005 | Thromb. Haemost. | pmid:15886792 |
| Chacón P et al. | Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. | 2005 | Eur. J. Immunol. | pmid:15997464 |
| Honma Y et al. | Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. | 2005 | Eur. J. Pharmacol. | pmid:16000196 |
| Kim HJ et al. | 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. | 2005 | Exp. Mol. Med. | pmid:16000871 |
| Burgess HA et al. | PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15734787 |
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| Lappas M et al. | Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranes. | 2004 Sep-Oct | Placenta | pmid:15450387 |
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| Kasim-Karakas SE et al. | Metabolic and endocrine effects of a polyunsaturated fatty acid-rich diet in polycystic ovary syndrome. | 2004 | J. Clin. Endocrinol. Metab. | pmid:14764771 |
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| Miwa Y et al. | Physiology and pharmacology of the prostaglandin J2 family. | 2004 | Nippon Yakurigaku Zasshi | pmid:14695456 |
| Fernández-Tome M et al. | COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue. | 2004 | Biochem. Pharmacol. | pmid:14698037 |
| Matsuo T et al. | 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14741709 |
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| Józkowicz A et al. | 15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560113 |
| Abraha D et al. | (S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. | 2004 | Int. Arch. Allergy Immunol. | pmid:15031612 |
| Rodway HA et al. | Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells. | 2004 | Biochem. J. | pmid:15171682 |
| Morii E and Oboki K | MITF is necessary for generation of prostaglandin D2 in mouse mast cells. | 2004 | J. Biol. Chem. | pmid:15375155 |
| Marone G et al. | The human heart as a shock organ in anaphylaxis. | 2004 | Novartis Found. Symp. | pmid:15025396 |
| Qin C et al. | A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. | 2004 | Mol. Cancer Ther. | pmid:15026545 |
| Hashimoto K et al. | Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. | 2004 | Pancreas | pmid:15028947 |
| Toyomoto M et al. | Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures. | 2004 | FEBS Lett. | pmid:15044028 |
| Tanaka K et al. | Effects of prostaglandin D2 on helper T cell functions. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15044085 |
| Onozaki A et al. | Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF: inhibitory effects of thiazolidinedione. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047143 |
| Koda N et al. | Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS. | 2004 | Arch. Biochem. Biophys. | pmid:15047184 |
| Saydam O et al. | Transactivator protein BICP0 of bovine herpesvirus 1 (BHV-1) is blocked by prostaglandin D2 (PGD2), which points to a mechanism for PGD2-mediated inhibition of BHV-1 replication. | 2004 | J. Virol. | pmid:15047795 |
| Woolhiser MR et al. | Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. | 2004 | Clin. Immunol. | pmid:15003814 |
| Relic B et al. | 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. | 2004 | J. Biol. Chem. | pmid:15004016 |
| Angeli V et al. | Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses. | 2004 | J. Immunol. | pmid:15004188 |
| Lupi R et al. | Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:14625208 |
| Tsuji T et al. | Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. | 2004 | Biol. Pharm. Bull. | pmid:15467193 |
| Konopleva M et al. | Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. | 2004 | Mol. Cancer Ther. | pmid:15486192 |
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| Li Z et al. | Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? | 2004 | J. Neurosci. Res. | pmid:15523637 |
| Liu JD et al. | Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. | 2004 | Life Sci. | pmid:14998722 |
| Sabichi AL et al. | Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15533896 |
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| Eucker J et al. | Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. | 2004 | Anticancer Drugs | pmid:15514564 |
| Yoshida M et al. | Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519494 |
| Giri S et al. | The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. | 2004 | J. Immunol. | pmid:15470065 |
| Hayaishi O et al. | Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. | 2004 | Arch Ital Biol | pmid:15493554 |
| Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
| Higashihara H et al. | Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. | 2004 | Redox Rep. | pmid:15720834 |
| Takagi T et al. | A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. | 2004 | Redox Rep. | pmid:15720836 |
| Mix KS et al. | Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. | 2004 | Mol. Pharmacol. | pmid:14742672 |
| Baek SJ et al. | Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. | 2004 | J. Biol. Chem. | pmid:14662774 |
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| Ehara N et al. | Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358182 |
| Yuan ZY et al. | PPAR-gamma ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis. | 2004 | Chin. Med. J. | pmid:15361304 |
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| Hirata Y et al. | Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells. | 2004 | Brain Res. | pmid:15342272 |
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| Weber SM et al. | PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15315910 |
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| Morosetti R et al. | The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. | 2004 | Int. J. Oncol. | pmid:15254749 |
| Hofnagel O et al. | Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15271788 |
| Park KS et al. | Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. | 2004 | Exp. Cell Res. | pmid:15212945 |
| Shan ZZ et al. | A potential role of 15-deoxy-delta(12,14)-prostaglandin J2 for induction of human articular chondrocyte apoptosis in arthritis. | 2004 | J. Biol. Chem. | pmid:15213234 |
| Tanaka Y et al. | Enhanced release of prostaglandin D2 during re-incubation of RAW 264.7 macrophage-like cells after treatment of both lipopolysaccharide and non-steroidal anti-inflammatory drugs. | 2004 | Biol. Pharm. Bull. | pmid:15256727 |
| Jawerbaum A et al. | Influence of peroxisome proliferator-activated receptor gamma activation by its endogenous ligand 15-deoxy Delta12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women. | 2004 | Mol. Hum. Reprod. | pmid:15258247 |
| Zhao ML et al. | 15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. | 2004 | J. Neuroimmunol. | pmid:15265671 |
| Zhang X et al. | Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells. | 2004 | Blood | pmid:15265789 |
| Azuma Y et al. | Induction of proliferation by 15-deoxy-delta12,14-prostaglandin J2 and the precursors in monocytic leukemia U937. | 2004 | Pharmacology | pmid:15240994 |
| Zhang C et al. | The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) induces apoptosis in Mycosis fungoides/Sézary syndrome cells. | 2004 | J. Invest. Dermatol. | pmid:15245439 |
| Siavash H et al. | Targeting of epidermal growth factor receptor by cyclopentenone prostaglandin 15-Deoxy-Delta12,14-prostaglandin J2 in human oral squamous carcinoma cells. | 2004 | Cancer Lett. | pmid:15194221 |
| Li Z et al. | Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15194490 |
| Ruiz PA et al. | 15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. | 2004 | J. Biol. Chem. | pmid:15199053 |
| Shimomura K et al. | Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15201343 |
| Hawcroft G et al. | Expression of prostaglandin D2 receptors DP1 and DP2 by human colorectal cancer cells. | 2004 | Cancer Lett. | pmid:15172124 |
| Son DJ et al. | Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15172681 |
| Takeshita K et al. | CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. | 2004 | Int. Immunol. | pmid:15173122 |
| Cipollone F et al. | Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15155382 |
| Leung WK et al. | Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. | 2004 | Gut | pmid:14960510 |
| Mouihate A et al. | A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. | 2004 | J. Neurosci. | pmid:14960602 |
| Chatterjee PK et al. | The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. | 2004 | Cardiovasc. Res. | pmid:14962493 |
| Brummond KM et al. | The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry. | 2004 | Org. Lett. | pmid:14723515 |