| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walusinski O | How yawning switches the default-mode network to the attentional network by activating the cerebrospinal fluid flow. | 2014 | Clin Anat | pmid:23813685 |
| Korolczuk A et al. | The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity. | 2014 | J. Physiol. Pharmacol. | pmid:25554991 |
| Isensee J et al. | Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. | 2014 | PLoS ONE | pmid:25551770 |
| Gonzalez-Rodriguez PJ et al. | Dexamethasone protects neonatal hypoxic-ischemic brain injury via L-PGDS-dependent PGD2-DP1-pERK signaling pathway. | 2014 | PLoS ONE | pmid:25474649 |
| Miller NR et al. | Sustained neuroprotection from a single intravitreal injection of PGJâ‚‚ in a nonhuman primate model of nonarteritic anterior ischemic optic neuropathy. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25298416 |
| Savinainen JR et al. | Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). | 2014 | PLoS ONE | pmid:25290914 |
| Kuroyanagi G et al. | Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24813642 |
| Moon TC et al. | Expression of DP2 (CRTh2), a prostaglandin Dâ‚‚ receptor, in human mast cells. | 2014 | PLoS ONE | pmid:25268140 |
| Afrin LB | Mast cell activation syndrome as a significant comorbidity in sickle cell disease. | 2014 | Am. J. Med. Sci. | pmid:25171546 |
| Samikkannu T et al. | Immunopathogenesis of HIV infection in cocaine users: role of arachidonic acid. | 2014 | PLoS ONE | pmid:25171226 |
| Cantley JL et al. | Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:25159329 |
| Savinainen JR et al. | Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL). | 2014 | Mol. Pharmacol. | pmid:25140003 |
| Dichlberger A et al. | Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. | 2014 | J. Lipid Res. | pmid:25114172 |
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| Huang HL et al. | 18F-glutathione conjugate as a PET tracer for imaging tumors that overexpress L-PGDS enzyme. | 2014 | PLoS ONE | pmid:25111383 |
| Wasinger C et al. | Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells. | 2014 | Br. J. Pharmacol. | pmid:25091578 |
| Elremaly W et al. | Ascorbylperoxide from parenteral nutrition induces an increase of redox potential of glutathione and loss of alveoli in newborn guinea pig lungs. | 2014 | Redox Biol | pmid:25009773 |
| Paakinaho V et al. | Electrophilic lipid mediator 15-deoxy-Δ12,14-prostaglandin j2 modifies glucocorticoid signaling via receptor SUMOylation. | 2014 | Mol. Cell. Biol. | pmid:24980431 |
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| Mantel A et al. | Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. | 2014 | Exp. Dermatol. | pmid:24917395 |
| Tang J et al. | Aspirin treatment improved mesenchymal stem cell immunomodulatory properties via the 15d-PGJ2/PPARγ/TGF-β1 pathway. | 2014 | Stem Cells Dev. | pmid:24730450 |
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| Tippin BL et al. | Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR. | 2014 | Cancer Med | pmid:24729479 |
| Koyani CN et al. | 15-deoxy-Δ¹²,¹â´-PGJâ‚‚ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis. | 2014 | Int. J. Cardiol. | pmid:24698234 |
| Jeon KI et al. | Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformation. | 2014 | Am. J. Pathol. | pmid:24650561 |
| Yen CC et al. | Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. | 2014 | Oncotarget | pmid:24566468 |
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| Jeong KT et al. | Anti-allergic effect of a Korean traditional medicine, Biyeom-Tang on mast cells and allergic rhinitis. | 2014 | BMC Complement Altern Med | pmid:24521096 |
| Chang JE et al. | Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. | 2014 | J. Allergy Clin. Immunol. | pmid:24210841 |
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| Olsen KC et al. | Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24175906 |
| GarcÃa-Bueno B et al. | Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. | 2014 | Schizophr Bull | pmid:23486748 |
| Filep JG | Glucocorticoid protection against myocardial ischemia-reperfusion injury: central role for the PGD2-Nrf2 pathway. | 2014 | Hypertension | pmid:24101660 |
| Sturm EM et al. | Opposing roles of prostaglandin D2 receptors in ulcerative colitis. | 2014 | J. Immunol. | pmid:24929001 |
| Steinke JW et al. | Aspirin activation of eosinophils and mast cells: implications in the pathogenesis of aspirin-exacerbated respiratory disease. | 2014 | J. Immunol. | pmid:24890720 |
| Iwanaga K et al. | Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. | 2014 | Cancer Res. | pmid:24879565 |
| Song Y et al. | [PPAR-γ agonist inhibits the expressions of chemokines induced by IFN-γ and TNF-α in renal tubular epithelial cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25001926 |
| Shivers KY et al. | PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. | 2014 | Biochim. Biophys. Acta | pmid:24970746 |
| Kumar S et al. | Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction. | 2014 | Int. Immunopharmacol. | pmid:24468678 |
| Bhargava S | Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer. | 2014 | Med. Hypotheses | pmid:24548754 |
| Yue L et al. | Prostaglandin D(2) induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways. | 2014 | Bone | pmid:24345643 |
| Han XQ et al. | Advanced glycation end products promote differentiation of CD4(+) T helper cells toward pro-inflammatory response. | 2014 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:24496672 |
| Tachi M et al. | Mass spectrometric determination of prostanoids in rat hypothalamic paraventricular nucleus microdialysates. | 2014 | Auton Neurosci | pmid:24447364 |
| Wong GW et al. | Ancient origin of mast cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25094046 |
| Kurtz M et al. | Peroxisome proliferator-activated receptor ligands regulate lipid content, metabolism, and composition in fetal lungs of diabetic rats. | 2014 | J. Endocrinol. | pmid:24389592 |
| Jung WK et al. | The 15-deoxy-δ12,14-prostaglandin J2 inhibits LPS‑stimulated inflammation via enhancement of the platelet‑activating factor acetylhydrolase activity in human retinal pigment epithelial cells. | 2014 | Int. J. Mol. Med. | pmid:24337644 |
| Carrier EJ et al. | Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. | 2014 | Biochemistry | pmid:24684440 |
| Oyama S et al. | A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. | 2014 | Arch. Biochem. Biophys. | pmid:24239863 |
| Liu H et al. | Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus. | 2014 | Immunology | pmid:24329550 |
| Chen S et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) promotes apoptosis of HBx-positive liver cells. | 2014 | Chem. Biol. Interact. | pmid:24582817 |
| Brugha RE et al. | Carbon in airway macrophages from children with asthma. | 2014 | Thorax | pmid:24567296 |
| Pierron A et al. | PGJ2 restores RA sensitivity in melanoma cells by decreasing PRAME and EZH2. | 2014 | J. Dermatol. Sci. | pmid:24289988 |
| Moniot B et al. | Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. | 2014 | Development | pmid:25142465 |
| Xue L et al. | Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells. | 2014 | J. Allergy Clin. Immunol. | pmid:24388011 |
| Pradhan A and Olsson PE | Juvenile ovary to testis transition in zebrafish involves inhibition of ptges. | 2014 | Biol. Reprod. | pmid:24920039 |
| Martins CA et al. | Malva sylvestris L. extract suppresses desferrioxamine-induced PGEâ‚‚ and PGDâ‚‚ release in differentiated U937 cells: the development and validation of an LC-MS/MS method for prostaglandin quantification. | 2014 | Biomed. Chromatogr. | pmid:24403179 |
| Manna JD et al. | Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. | 2014 | J. Biol. Chem. | pmid:25301951 |
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| Mooney JJ et al. | Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: an exploratory study. | 2013 | J Psychiatr Res | pmid:23490066 |
| Keum JH et al. | The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells. | 2013 | Chin J Integr Med | pmid:23494327 |
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| Zhang S et al. | Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23471341 |
| Welter H et al. | Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. | 2013 | Andrology | pmid:23413143 |
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| Kanda H et al. | COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. | 2013 | Glia | pmid:23505121 |
| Brose SA et al. | A fast one-step extraction and UPLC-MS/MS analysis for E2/D 2 series prostaglandins and isoprostanes. | 2013 | Lipids | pmid:23400687 |
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| Wappler EA et al. | Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. | 2013 | PLoS ONE | pmid:23658809 |
| Krohn IK et al. | Mast cell FcϵRI density and function dissociate from dependence on soluble IgE concentration at very low and very high IgE concentrations. | 2013 | J Asthma | pmid:23294195 |
| Rank MA et al. | Systemic reactions to allergen immunotherapy: a role for measuring a PGD2 metabolite? | 2013 | Ann. Allergy Asthma Immunol. | pmid:23244662 |
| Ramer R et al. | COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells. | 2013 | Mol. Cancer Ther. | pmid:23220503 |
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| Sato A et al. | Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23566516 |
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| Yoo JM et al. | Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. | 2013 | Lipids | pmid:23377981 |
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| Touitou V et al. | Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:24106118 |
| Tofield A | Niacin and statin intolerable for some people. | 2013 | Eur. Heart J. | pmid:24137778 |
| Napimoga MH et al. | Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner. | 2013 | Int. Immunopharmacol. | pmid:23597428 |
| Ramer R et al. | Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. | 2013 | J. Lipid Res. | pmid:23943857 |
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| Penas F et al. | PPARγ ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi. | 2013 | Biochim. Biophys. Acta | pmid:22917565 |