PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Sayers BC et al. Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. 2013 Am. J. Respir. Cell Mol. Biol. pmid:23642096
Cruse G et al. A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells. 2013 Immunity pmid:23643722
Wappler EA et al. Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. 2013 PLoS ONE pmid:23658809
Starkl P et al. PLA2G3 promotes mast cell maturation and function. 2013 Nat. Immunol. pmid:23685814
Shyu RY et al. H-rev107 regulates prostaglandin D2 synthase-mediated suppression of cellular invasion in testicular cancer cells. 2013 J. Biomed. Sci. pmid:23687991
Hau CS et al. Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes. 2013 J. Dermatol. Sci. pmid:23688403
Liu MC et al. Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. 1990 Am. Rev. Respir. Dis. pmid:2368958
Xu X et al. Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation. 2013 Steroids pmid:23707573
Lu Y et al. Manassantin B isolated from Saururus chinensis inhibits cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Fyn-mediated nuclear factor-kappaB and mitogen activated protein kinase pathways in bone marrow derived-mast cells. 2013 Biol. Pharm. Bull. pmid:23719635
Lefils-Lacourtablaise J et al. The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. 2013 PLoS ONE pmid:23734181
Moghaddami M et al. Prostaglandin D(2) in inflammatory arthritis and its relation with synovial fluid dendritic cells. 2013 Mediators Inflamm. pmid:23737645
García-Sáinz JA et al. Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. 1990 Biochem. J. pmid:2375756
Juman S et al. Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. 2013 Nutrients pmid:23760060
Labrecque P et al. Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. 2013 PLoS ONE pmid:23762421
Safaralizadeh R et al. Influence of selenium on mast cell mediator release. 2013 Biol Trace Elem Res pmid:23784732
Hellmann J et al. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. 2013 J. Immunol. pmid:23785121
Jabr S et al. Quantification of major urinary metabolites of PGE2 and PGD2 in cystic fibrosis: correlation with disease severity. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23791427
Walusinski O How yawning switches the default-mode network to the attentional network by activating the cerebrospinal fluid flow. 2014 Clin Anat pmid:23813685
Rahman MS et al. Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes. 2013 Appl. Biochem. Biotechnol. pmid:23817787
Takayama F et al. Possible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia. 2013 J. Neuroimmunol. pmid:23850486
Aldrovandi M et al. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. 2013 J. Lipid Res. pmid:23883581
Fujishima H et al. Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. 2013 Ann. Allergy Asthma Immunol. pmid:23886231
Lu Y et al. 15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells. 2013 Nephron Exp. Nephrol. pmid:23887394
Idborg H et al. Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice. 2013 Prostaglandins Other Lipid Mediat. pmid:23916744
Buckner MM et al. 15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium. 2013 PLoS ONE pmid:23922794
Ramer R et al. Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. 2013 J. Lipid Res. pmid:23943857
vom Dahl S et al. Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine. 1990 Biochem. J. pmid:2396991
Liu H et al. Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. 2013 Neurotoxicology pmid:23973622
Kaur R et al. A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds. 2013 J Biomol Screen pmid:23983232
Endo S et al. Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin Dâ‚‚, and other endogenous and xenobiotic carbonyl compounds. 2013 Biochem. Pharmacol. pmid:23994167
Quan GH et al. Anti-allergic flavones from Arthraxon hispidus. 2013 Chem. Pharm. Bull. pmid:23995356
Huisingh C and McGwin G Change in prostaglandin expression levels and synthesizing activities. 2013 Ophthalmology pmid:24001535
Rim TH et al. Author reply: To PMID 22858125. 2013 Ophthalmology pmid:24001536
Liu L et al. Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. 2013 PLoS ONE pmid:24023668
Harizi H The immunobiology of prostanoid receptor signaling in connecting innate and adaptive immunity. 2013 Biomed Res Int pmid:24024207
Kaplan J et al. Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis. 2014 Innate Immun pmid:24029145
Kim KH et al. Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2. 2013 Free Radic. Biol. Med. pmid:24029383
Urade Y et al. Mast cells contain spleen-type prostaglandin D synthetase. 1990 J. Biol. Chem. pmid:2403560
Deffebach ME et al. Prostaglandins alter methacholine-induced secretion in ferret in vitro trachea. 1990 Am. J. Physiol. pmid:2407140
Lewis RA et al. Pharmacologic regulation of mediator generation and release from the murine bone marrow derived mast cell. 1985 Int. Arch. Allergy Appl. Immunol. pmid:2409010
Norman PS et al. Mediator release after allergic and physical nasal challenges. 1985 Int. Arch. Allergy Appl. Immunol. pmid:2409027
Sharvit E et al. Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists. 2013 PLoS ONE pmid:24098526
Alhouayek M et al. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24101490
Filep JG Glucocorticoid protection against myocardial ischemia-reperfusion injury: central role for the PGD2-Nrf2 pathway. 2014 Hypertension pmid:24101660
Katsumata Y et al. Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2. 2014 Hypertension pmid:24101662
Schleimer RP et al. Role of human basophils and mast cells in the pathogenesis of allergic diseases. 1985 J. Allergy Clin. Immunol. pmid:2410478
Touitou V et al. Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy. 2013 Invest. Ophthalmol. Vis. Sci. pmid:24106118
Lad PM et al. Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils. 1985 Biochim. Biophys. Acta pmid:2411298
Finney MJ et al. Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. 1985 Br. J. Pharmacol. pmid:2411319
Brose SA and Golovko MY Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24113545
Fowler JC et al. Prostaglandins block a Ca2+-dependent slow spike afterhyperpolarization independent of effects on Ca2+ influx in visceral afferent neurons. 1985 Brain Res. pmid:2412652
Levi-Schaffer F et al. Fibroblasts maintain the phenotype and viability of the rat heparin-containing mast cell in vitro. 1985 J. Immunol. pmid:2413121
Forman MB et al. Increased adventitial mast cells in a patient with coronary spasm. 1985 N. Engl. J. Med. pmid:2413358
Kuriyan AE et al. Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. 2013 Invest. Ophthalmol. Vis. Sci. pmid:24135759
Tofield A Niacin and statin intolerable for some people. 2013 Eur. Heart J. pmid:24137778
Togias AG et al. Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement. 1985 J. Clin. Invest. pmid:2414318
Holgate ST The role of mast cells in the pathogenesis of asthma. 1985 Sep-Oct Bull Eur Physiopathol Respir pmid:2415192
Schulman ES and Anderson CL Lung hypersensitivity responses: dissociation of human lung mast cell leukotriene C4 (LTC4) from histamine release. 1985 Prog. Clin. Biol. Res. pmid:2415994
Zhang S et al. Prostaglandin D2 receptor D-type prostanoid receptor 2 mediates eosinophil trafficking into the esophagus. 2014 Dis. Esophagus pmid:24165271
Creticos PS et al. Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy. 1985 J. Clin. Invest. pmid:2416777
Wu D et al. Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. 2013 Mediators Inflamm. pmid:24174713
Olsen KC et al. Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. 2014 Am. J. Respir. Cell Mol. Biol. pmid:24175906
Holgate ST et al. The release and role of inflammatory mediators in asthma. 1985 Clin Immunol Rev pmid:2417772
Kang ES et al. 15-Deoxy-Δ(12,14)-prostaglandin J2 prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells. 2014 Free Radic. Res. pmid:24180671
Mruwat R et al. Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models. 2013 PLoS ONE pmid:24204651
Chang JE et al. Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. 2014 J. Allergy Clin. Immunol. pmid:24210841
Oyama S et al. A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. 2014 Arch. Biochem. Biophys. pmid:24239863
Peters SP et al. Mediator release from human lung under conditions of reduced oxygen tension. 1986 J. Pharmacol. Exp. Ther. pmid:2425080
MacDermot J Desensitization of prostacyclin responsiveness in platelets. Apparent differences in the mechanism in vitro or in vivo. 1986 Biochem. Pharmacol. pmid:2427086
Bogacka I et al. The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. 2013 Reprod Biol pmid:24287039
Heavey DJ et al. Prostaglandin D2 and histamine release in cold urticaria. 1986 J. Allergy Clin. Immunol. pmid:2428856
Pierron A et al. PGJ2 restores RA sensitivity in melanoma cells by decreasing PRAME and EZH2. 2014 J. Dermatol. Sci. pmid:24289988
Wang C et al. A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. 2014 Nat. Methods pmid:24292485
Sarashina H et al. Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation. 2014 J. Immunol. pmid:24298012
Eady RP The pharmacology of nedocromil sodium. 1986 Eur J Respir Dis Suppl pmid:2429854
Kleeberger SR et al. Central role of cyclooxygenase in the response of canine peripheral airways to antigen. 1986 J. Appl. Physiol. pmid:2430928
Wells E et al. Characterization of primate bronchoalveolar mast cells. I. IgE-dependent release of histamine, leukotrienes, and prostaglandins. 1986 J. Immunol. pmid:2431048
Wells E et al. Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mast cells. 1986 J. Immunol. pmid:2431049
Ashby B Kinetic evidence indicating separate stimulatory and inhibitory prostaglandin receptors on platelet membranes. 1986 J Cyclic Nucleotide Protein Phosphor Res pmid:2432105
Koro O et al. Release of prostaglandin D2 and histamine in a case of localized heat urticaria, and effect of treatments. 1986 Br. J. Dermatol. pmid:2432916
Liu H et al. Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus. 2014 Immunology pmid:24329550
Kozuka T et al. Prostaglandin D2 release by guinea pig skin during in vitro anaphylaxis induced by antigen and compound 48/80. 1987 J. Invest. Dermatol. pmid:2433354
Jung WK et al. The 15-deoxy-δ12,14-prostaglandin J2 inhibits LPS‑stimulated inflammation via enhancement of the platelet‑activating factor acetylhydrolase activity in human retinal pigment epithelial cells. 2014 Int. J. Mol. Med. pmid:24337644
Yue L et al. Prostaglandin D(2) induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways. 2014 Bone pmid:24345643
pmid:24352801
Jacobsen S et al. Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells. 1987 Biochem. Pharmacol. pmid:2435291
Church MK and Hiroi J Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. 1987 Br. J. Pharmacol. pmid:2435353
Kawabe H et al. Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. 1987 Biochem. Biophys. Res. Commun. pmid:2436614
Chi Y et al. [Effect of 15-deoxy-Δ(12), 14-prostaglandin J2 on the cytokines in the culture supernatant of bone marrow mesenchymal stem cells]. 2013 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:24370048
Pearce FL et al. Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue. 1987 Int. Arch. Allergy Appl. Immunol. pmid:2437052
Weinreich D and Undem BJ Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia. 1987 J. Clin. Invest. pmid:2437156
Yaacob NS et al. Influence of 17β-estradiol on 15-deoxy-δ12,14 prostaglandin J2 -induced apoptosis in MCF-7 and MDA-MB-231 cells. 2013 Asian Pac. J. Cancer Prev. pmid:24377602
Abdel-Malek ZA et al. In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. 1987 Cancer Res. pmid:2438034
Xue L et al. Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells. 2014 J. Allergy Clin. Immunol. pmid:24388011
Kurtz M et al. Peroxisome proliferator-activated receptor ligands regulate lipid content, metabolism, and composition in fetal lungs of diabetic rats. 2014 J. Endocrinol. pmid:24389592
Levi-Schaffer F et al. Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. 1987 J. Immunol. pmid:2439587
Leung KB et al. Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue. 1987 Agents Actions pmid:2440274
Martins CA et al. Malva sylvestris L. extract suppresses desferrioxamine-induced PGEâ‚‚ and PGDâ‚‚ release in differentiated U937 cells: the development and validation of an LC-MS/MS method for prostaglandin quantification. 2014 Biomed. Chromatogr. pmid:24403179
Underwood DC et al. Blockade of thromboxane responses in the airway of the cat by SQ 29,548. 1987 J. Appl. Physiol. pmid:2440845
Reddy PH Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction. 2014 J. Alzheimers Dis. pmid:24413616