| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Church MK et al. | Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. | 1987 | Clin. Allergy | pmid:2441900 |
| Kosaka Y et al. | Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung. | 1987 | Agents Actions | pmid:2442981 |
| Pipkorn U et al. | Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. | 1987 | J. Clin. Invest. | pmid:2443539 |
| Williams KA et al. | Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. | 1987 | Biochem. J. | pmid:2444206 |
| Lawrence ID et al. | Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. | 1987 | J. Immunol. | pmid:2444649 |
| Tachi M et al. | Mass spectrometric determination of prostanoids in rat hypothalamic paraventricular nucleus microdialysates. | 2014 | Auton Neurosci | pmid:24447364 |
| pmid:24456221 | ||||
| Levi-Schaffer F et al. | Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. | 1987 | J. Immunol. | pmid:2445814 |
| Kumar S et al. | Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction. | 2014 | Int. Immunopharmacol. | pmid:24468678 |
| pmid:24471457 | ||||
| Benyon RC et al. | Prostaglandin D2 release from human skin mast cells in response to ionophore A23187. | 1987 | Br. J. Pharmacol. | pmid:2447989 |
| Schulman ES et al. | Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. | 1988 | J. Clin. Invest. | pmid:2449462 |
| Han XQ et al. | Advanced glycation end products promote differentiation of CD4(+) T helper cells toward pro-inflammatory response. | 2014 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:24496672 |
| Heavey DJ et al. | Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. | 1988 | J. Immunol. | pmid:2450136 |
| Robinson C et al. | The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells. | 1988 | J. Invest. Dermatol. | pmid:2450144 |
| Holgate ST et al. | The contribution of mast cell mediators to acute allergic reactions in human skin and airways. | 1988 | Allergy | pmid:2451448 |
| Jeong KT et al. | Anti-allergic effect of a Korean traditional medicine, Biyeom-Tang on mast cells and allergic rhinitis. | 2014 | BMC Complement Altern Med | pmid:24521096 |
| Nieves A and Garza LA | Does prostaglandin D2 hold the cure to male pattern baldness? | 2014 | Exp. Dermatol. | pmid:24521203 |
| Bhargava S | Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer. | 2014 | Med. Hypotheses | pmid:24548754 |
| Schulman ES et al. | Density heterogeneity of human lung mast cells. | 1988 | J. Allergy Clin. Immunol. | pmid:2455745 |
| pmid:24565634 | ||||
| Yen CC et al. | Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. | 2014 | Oncotarget | pmid:24566468 |
| Brugha RE et al. | Carbon in airway macrophages from children with asthma. | 2014 | Thorax | pmid:24567296 |
| pmid:24568186 | ||||
| pmid:24571868 | ||||
| Chen S et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) promotes apoptosis of HBx-positive liver cells. | 2014 | Chem. Biol. Interact. | pmid:24582817 |
| Ormerod AD et al. | Prostaglandin D2 and histamine release in cold urticaria unaccompanied by evidence of platelet activation. | 1988 | J. Allergy Clin. Immunol. | pmid:2459177 |
| Undem BJ et al. | Isoproterenol-induced inhibition of immunoglobulin E-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2459368 |
| Keery RJ and Lumley P | AH6809, a prostaglandin DP-receptor blocking drug on human platelets. | 1988 | Br. J. Pharmacol. | pmid:2460179 |
| Barr RM et al. | The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions. | 1988 | Br. J. Pharmacol. | pmid:2460180 |
| Michel L et al. | Prostaglandin D2 generation in mouse bone marrow-derived mast cells exposed to dexamethasone is associated with endogenous peroxidase activity. | 1988 | Lab. Invest. | pmid:2460694 |
| Lebel B et al. | Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. | 1988 | J. Allergy Clin. Immunol. | pmid:2461405 |
| Bousquet J et al. | Antiallergic activity of H1-receptor antagonists assessed by nasal challenge. | 1988 | J. Allergy Clin. Immunol. | pmid:2461406 |
| Church MM et al. | The mediator and cellular basis of the allergic response. | 1988 | Allergy | pmid:2462372 |
| Takei M et al. | Role of cyclic AMP during histamine release. Histamine release is not directly related to increase in cyclic AMP levels in rat mast cells activated by concanavalin A, anti-IgE, antigen, prostaglandin D2 and isoproterenol. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:2463844 |
| pmid:24639050 | ||||
| Jeon KI et al. | Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformation. | 2014 | Am. J. Pathol. | pmid:24650561 |
| Marone G | Control mechanisms of mediator release in human basophils and mast cells. | 1988 Nov-Dec | Immunol. Invest. | pmid:2465995 |
| Miadonna A et al. | Mediators and allergic inflammation of human airways. | 1988 | Respiration | pmid:2466314 |
| Trist DG et al. | The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. | 1989 | Br. J. Pharmacol. | pmid:2466517 |
| pmid:24680891 | ||||
| Lebel B et al. | Spontaneous and non-specific release of histamine and PGD2 by bronchoalveolar lavage cells from asthmatic and normal subjects: effect of nedocromil sodium. | 1988 | Clin. Allergy | pmid:2468432 |
| Carrier EJ et al. | Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. | 2014 | Biochemistry | pmid:24684440 |
| Triggiani M et al. | Inhibition of histamine and prostaglandin D2 release from human lung mast cells by ciclosporin A. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468619 |
| Charlesworth EN et al. | Cells and secretagogues involved in the human late-phase response. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468620 |
| Church MK et al. | Interaction of neuropeptides with human mast cells. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468622 |
| Charlesworth EN et al. | Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. | 1989 | J. Clin. Invest. | pmid:2468688 |
| Ohuchi K et al. | Stimulation of histamine release and arachidonic acid metabolism in rat peritoneal mast cells by thapsigargin, a non-TPA-type tumor promoter. | 1989 | Biochim. Biophys. Acta | pmid:2469475 |
| Charlesworth EN et al. | Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction. | 1989 | J. Allergy Clin. Immunol. | pmid:2469708 |
| Koyani CN et al. | 15-deoxy-Δ¹²,¹â´-PGJâ‚‚ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis. | 2014 | Int. J. Cardiol. | pmid:24698234 |
| Tippin BL et al. | Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR. | 2014 | Cancer Med | pmid:24729479 |
| Tang J et al. | Aspirin treatment improved mesenchymal stem cell immunomodulatory properties via the 15d-PGJ2/PPARγ/TGF-β1 pathway. | 2014 | Stem Cells Dev. | pmid:24730450 |
| Church MK et al. | Mast cells, neuropeptides and inflammation. | 1989 | Agents Actions | pmid:2473641 |
| van Overveld FJ | Mediator release from human lung mast cell subtypes in chronic bronchitis and emphysema. | 1989 | Agents Actions | pmid:2473645 |
| Takeshima Y | [Development of novel therapeutic approaches for Duchenne muscular dystrophy]. | 2014 | No To Hattatsu | pmid:24738186 |
| Benyon RC et al. | Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. | 1989 | Br. J. Pharmacol. | pmid:2474353 |
| Ikai K et al. | Inhibitory effect of tranilast on prostaglandin D synthetase. | 1989 | Biochem. Pharmacol. | pmid:2475113 |
| pmid:24755408 | ||||
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. | 1989 | Prostaglandins | pmid:2475889 |
| Dubertret L et al. | Biological and cellular responses to grass pollen in sensitive patients. | 1989 | Dermatologica | pmid:2476344 |
| pmid:24767875 | ||||
| Wachs M et al. | Observations on the pathogenesis of nasal priming. | 1989 | J. Allergy Clin. Immunol. | pmid:2477429 |
| Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
| Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
| Reshef A et al. | The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR). | 1989 | J. Allergy Clin. Immunol. | pmid:2478604 |
| Marone G et al. | Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion. | 1989 | Life Sci. | pmid:2480501 |
| Kuroyanagi G et al. | Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24813642 |
| Mello CF and Oliveira MS | Commentary on Kaushik et al.: Prostaglandin D2 is crucial for seizure suppression and postictal sleep. Novel evidence supporting a role for prostanoid receptors in seizure control. | 2014 | Exp. Neurol. | pmid:24814715 |
| Reiss TF et al. | Local mediator release after antigen challenge of a bronchial segment in allergic dogs. | 1989 | Am. J. Physiol. | pmid:2481982 |
| pmid:24820432 | ||||
| Levi-Schaffer F and Shalit M | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells activated with peptides. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2482257 |
| Stenson WF | The universe of arachidonic acid metabolites in inflammatory bowel disease: can we tell the good from the bad? | 2014 | Curr. Opin. Gastroenterol. | pmid:24837228 |
| Iwanaga K et al. | Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. | 2014 | Cancer Res. | pmid:24879565 |
| Steinke JW et al. | Aspirin activation of eosinophils and mast cells: implications in the pathogenesis of aspirin-exacerbated respiratory disease. | 2014 | J. Immunol. | pmid:24890720 |
| Casali CI et al. | Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells. | 2014 | Biochem. Pharmacol. | pmid:24915420 |
| Kim HJ et al. | ROSics: chemistry and proteomics of cysteine modifications in redox biology. | 2015 Mar-Apr | Mass Spectrom Rev | pmid:24916017 |
| Mantel A et al. | Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. | 2014 | Exp. Dermatol. | pmid:24917395 |
| Pradhan A and Olsson PE | Juvenile ovary to testis transition in zebrafish involves inhibition of ptges. | 2014 | Biol. Reprod. | pmid:24920039 |
| Sturm EM et al. | Opposing roles of prostaglandin D2 receptors in ulcerative colitis. | 2014 | J. Immunol. | pmid:24929001 |
| Asbóth G et al. | The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation. | 1989 | Biochim. Biophys. Acta | pmid:2493805 |
| Cichocka-Jarosz E et al. | Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children. | 2014 | Ann Agric Environ Med | pmid:24959779 |
| Froissart P et al. | Modulation by phorbol 12-myristate 13-acetate of arachidonic acid release from rat basophilic leukemia cells stimulated with A23187. | 1989 | Biochim. Biophys. Acta | pmid:2496761 |
| Shivers KY et al. | PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. | 2014 | Biochim. Biophys. Acta | pmid:24970746 |
| pmid:24975423 | ||||
| Yoshimura S et al. | Prostaglandin D2 receptor of mastocytoma P-815 cells--possible regulation by phosphorylation and dephosphorylation. | 1989 | Biochim. Biophys. Acta | pmid:2497784 |
| Paakinaho V et al. | Electrophilic lipid mediator 15-deoxy-Δ12,14-prostaglandin j2 modifies glucocorticoid signaling via receptor SUMOylation. | 2014 | Mol. Cell. Biol. | pmid:24980431 |
| pmid:24985010 | ||||
| Song Y et al. | [PPAR-γ agonist inhibits the expressions of chemokines induced by IFN-γ and TNF-α in renal tubular epithelial cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25001926 |
| Elremaly W et al. | Ascorbylperoxide from parenteral nutrition induces an increase of redox potential of glutathione and loss of alveoli in newborn guinea pig lungs. | 2014 | Redox Biol | pmid:25009773 |
| Lapointe DS and Olson MS | Platelet-activating factor-stimulated hepatic glycogenolysis is not mediated through cyclooxygenase-derived metabolites of arachidonic acid. | 1989 | J. Biol. Chem. | pmid:2501299 |
| pmid:25016088 | ||||
| Gray PR et al. | The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves. | 1989 | Am. Rev. Respir. Dis. | pmid:2502051 |
| Robinson C et al. | The IgE- and calcium-dependent release of eicosanoids and histamine from human purified cutaneous mast cells. | 1989 | J. Invest. Dermatol. | pmid:2504819 |
| Ikai K et al. | Prostaglandin D2, a mediator in both immediate and delayed-type immune reactions in the skin. | 1989 | Dermatologica | pmid:2506083 |
| pmid:25072357 | ||||
| Hatanaka M et al. | Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells. | 1989 | J. Neurochem. | pmid:2507741 |
| Wasinger C et al. | Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells. | 2014 | Br. J. Pharmacol. | pmid:25091578 |
| Wong GW et al. | Ancient origin of mast cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25094046 |
| Urade Y et al. | The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. | 1989 | J. Immunol. | pmid:2509561 |
| Ito S et al. | Prostaglandin D2: a biochemical perspective. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2510183 |