| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Radziszewski W et al. | Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins. | 1995 | Int. J. Cardiol. | pmid:8586470 |
| Small P and Barrett D | Evaluation of dust and dust mite nasal provocation. | 1995 | Ann. Allergy Asthma Immunol. | pmid:8603280 |
| Forman BM et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | 1995 | Cell | pmid:8521497 |
| Kliewer SA et al. | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | 1995 | Cell | pmid:8521498 |
| Hardy E et al. | Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. | 1995 | Thromb. Haemost. | pmid:8560425 |
| Osaka T and Hayaishi O | Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat. | 1995 | Neurosci. Res. | pmid:8545074 |
| Parker CW et al. | Modulation of IL-4 production in murine spleen cells by prostaglandins. | 1995 | Cell. Immunol. | pmid:7720090 |
| Peden DB and Dailey L | Modulation of mast cell functions by in vitro ozone exposure. | 1995 | Am. J. Physiol. | pmid:7611432 |
| Rabe KF et al. | Hydrogen peroxide contracts human airways in vitro: role of epithelium. | 1995 | Am. J. Physiol. | pmid:7573466 |
| Hartmann K et al. | Effect of CC chemokines on mediator release from human skin mast cells and basophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7580286 |
| De Vries GW et al. | An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. | 1995 | Br. J. Pharmacol. | pmid:7582550 |
| Negishi M et al. | Involvement of protein kinase in delta 12-prostaglandin J2-induced expression of rat heme oxygenase-1 gene. | 1995 | FEBS Lett. | pmid:7556684 |
| Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
| Ikai K et al. | Effect of cytotoxic prostaglandin, delta 12-prostaglandin J2 on E-cadherin expression in transformed epidermal cells in culture. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630918 |
| Hu ZQ et al. | An essential role of prostaglandin E on mouse mast cell induction. | 1995 | J. Immunol. | pmid:7636261 |
| van Haaster CM et al. | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases. | 1995 | Biochim. Biophys. Acta | pmid:7857988 |
| Leifke E et al. | In vivo comparative study of the seizure- and ischemia-induced synthesis of eicosanoids in the brain of gerbils. | 1994 Sep-Oct | Arch Int Pharmacodyn Ther | pmid:7710301 |
| Polosa R et al. | [Mast cell mediator release after endobronchial challenge with adenosine 5'-monophosphate in asthmatic subjects]. | 1994 Apr-Jun | Ann. Ital. Med. Int. | pmid:7522500 |
| Satoh S et al. | Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. | 1994 | Neurosci. Res. | pmid:7708292 |
| Rodrigues M et al. | Synergistic antiplatelet action of nitric oxide (NO) with PGD2 and its metabolite PGJ2--relevance for cerebral circulation? | 1994 | J. Physiol. Pharmacol. | pmid:7727795 |
| Warren JB et al. | PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation. | 1994 | Am. J. Physiol. | pmid:7515584 |
| Zhou W et al. | Lipid mediator production in acute and chronic pancreatitis in the rat. | 1994 | J. Surg. Res. | pmid:8277767 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation determines sensitivity to prostaglandins and virus infection. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965770 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965771 |
| Touqui L et al. | Excretion of platelet activating factor-acetylhydrolase and phospholipase A2 into nasal fluids after allergenic challenge: possible role in the regulation of platelet activating factor release. | 1994 | J. Allergy Clin. Immunol. | pmid:8027488 |
| Murphy PJ et al. | Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans. | 1994 | Physiol. Behav. | pmid:8047572 |
| Hoffmann R et al. | Regulation of interleukin-6 receptor expression in rat Kupffer cells: modulation by cytokines, dexamethasone and prostaglandin E2. | 1994 | J. Hepatol. | pmid:7814800 |
| Peden DB et al. | Hydrogen peroxide effects on rat mast cell function. | 1994 | Am. J. Physiol. | pmid:8048546 |
| Ohara H et al. | Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme. | 1994 | Biochim. Biophys. Acta | pmid:7948008 |
| Toth P et al. | Administration of human chorionic gonadotropin affects sleep-wake phases and other associated behaviors in cycling female rats. | 1994 | Brain Res. | pmid:7987667 |
| Kantha SS | Histamine-interleukin-prostaglandin pathway: a hypothesis for a biochemical cycle regulating sleep and wakefulness. | 1994 | Med. Hypotheses | pmid:7935077 |
| Fukushima M et al. | Prostaglandin J2 and related compounds. Mode of action in G1 arrest and preclinical results. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825837 |
| Moussard C et al. | Effect of chronic REM sleep deprivation on pituitary, hypothalamus and hippocampus PGE2 and PGD2 biosynthesis in the mouse. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846109 |
| Woodward DF and Lawrence RA | Identification of a single (FP) receptor associated with prostanoid-induced Ca2+ signals in Swiss 3T3 cells. | 1994 | Biochem. Pharmacol. | pmid:8185669 |
| Koyama Y and Hayaishi O | Modulation by prostaglandins of activity of sleep-related neurons in the preoptic/anterior hypothalamic areas in rats. | 1994 | Brain Res. Bull. | pmid:8124575 |
| Gotoh M et al. | Desensitization of prostaglandin F2 alpha receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes. | 1994 | Neurochem. Res. | pmid:8065525 |
| Magnussen H et al. | [Experimental effects of air pollutants on healthy probands and asthmatic patients]. | 1994 | Pneumologie | pmid:8183874 |
| Takasuka M et al. | FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor agonist (U-46619), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solution: structure-activity relationships. | 1994 | J. Med. Chem. | pmid:8289201 |
| Ishimoto T et al. | Contribution of phospholipases A2 and D to arachidonic acid liberation and prostaglandin D2 formation with increase in intracellular Ca2+ concentration in rat peritoneal mast cells. | 1994 | Eur. J. Biochem. | pmid:7508386 |
| Frieling T et al. | Effects of the inflammatory mediator prostaglandin D2 on submucosal neurons and secretion in guinea pig colon. | 1994 | Am. J. Physiol. | pmid:8304452 |
| Nukina S et al. | Glycogenolytic effect of adenosine involves ATP from hepatocytes and eicosanoids from Kupffer cells. | 1994 | Am. J. Physiol. | pmid:8304463 |
| Underwood DC et al. | Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301572 |
| Diener M and Gabato D | Thromboxane-like actions of prostaglandin D2 on the contractility of the rat colon in vitro. | 1994 | Acta Physiol. Scand. | pmid:8135127 |
| Grunnet N et al. | Absence of glycogen cycling in cultured rat hepatocytes. | 1994 | Arch. Biochem. Biophys. | pmid:8117107 |
| el-Lati SG et al. | Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells. | 1994 | J. Invest. Dermatol. | pmid:7513741 |
| D'Onofrio C et al. | Antiproliferative activity of cyclopentenone prostaglandins in early HTLV-1 infection is independent of IL-2 and is associated with HSP70 induction. | 1994 | Leukemia | pmid:7516027 |
| Okayama Y et al. | In vitro effects of H1-antihistamines on histamine and PGD2 release from mast cells of human lung, tonsil, and skin. | 1994 | Allergy | pmid:7518654 |
| Darius H et al. | Inhibition of human platelets and polymorphonuclear neutrophils by the potent and metabolically stable prostaglandin D2 analog ZK 118.182. | 1994 | Eur. J. Pharmacol. | pmid:7522176 |
| Takei M and Endo K | Histamine release and calcium concentrations in rat mast cells are dependent on intracellular ATP: effects of prostaglandin D2. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7524104 |
| Ko FN et al. | YC-1, a novel activator of platelet guanylate cyclase. | 1994 | Blood | pmid:7527671 |
| Closa D et al. | Prostaglandin D2, F2 alpha, E2, and E1 in early phase of experimental acute necrohemorrhagic pancreatitis in rats. | 1994 | Pancreas | pmid:7509066 |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. | 1994 | Arch Dermatol | pmid:7979442 |
| Sakuma S et al. | Existence of an enzymatic pathway furnishing arachidonic acid for prostaglandin synthesis from arachidonoyl CoA in rabbit kidney medulla. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048918 |
| Araki M et al. | Isoflurane modulates phorbol myristate acetate-, prostaglandin D2-, and prostaglandin E2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. | 1994 | Anesth. Analg. | pmid:7639362 |
| Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
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| Levasseur-Acker GM et al. | Effect of furosemide on prostaglandin synthesis by human nasal and bronchial epithelial cells in culture. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8136154 |
| Spatz M et al. | Vasoactive peptides and prostaglandin D2 in human cerebromicrovascular endothelium. | 1994 | J. Auton. Nerv. Syst. | pmid:7836668 |
| Armstrong RA and Talpain E | Comparison of the prostaglandin E (EP) receptor of human neutrophils and HL-60 cells differentiated with DMSO. | 1994 | Prostaglandins | pmid:7878190 |
| Small P et al. | Effects of intensity of early response to allergen on the late phase of both the nose and skin. | 1994 | Ann Allergy | pmid:8092561 |
| Matsumura H et al. | Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7991572 |
| Beckh K et al. | Direct regulation of bile secretion by prostaglandins in perfused rat liver. | 1994 | Hepatology | pmid:8175143 |
| Athari A et al. | Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine. | 1994 | Hepatology | pmid:8020883 |
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| Murakami M et al. | Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. | 1994 | J. Biol. Chem. | pmid:8071353 |
| Tran-Thi TA et al. | Effects of hypoxia on the oxygen-dependent metabolism of prostaglandins and adenosine in liver cells. | 1994 | J. Hepatol. | pmid:8071531 |
| Chen WY et al. | The effect of 3-[2-(cyclopropylamino)ethoxy]xanthone on platelet thromboxane formation. | 1994 | Thromb. Res. | pmid:8073410 |
| al Jarad N et al. | Effects of a thromboxane receptor antagonist on prostaglandin D2 and histamine induced bronchoconstriction in man. | 1994 | Br J Clin Pharmacol | pmid:8148229 |
| Amon U et al. | Investigations on plasma levels of mast cell mediators in acute atopic dermatitis. | 1994 | J. Dermatol. Sci. | pmid:8193085 |
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| Awad JA et al. | Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell activation. | 1994 | J. Allergy Clin. Immunol. | pmid:8182221 |
| Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
| Minami T et al. | Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. | 1994 | Pain | pmid:7916452 |
| Wu CC et al. | Antiplatelet effects of clausine-D isolated from Clausena excavata. | 1994 | Biochim. Biophys. Acta | pmid:7918571 |
| Sichletidis L et al. | Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. | 1993 Mar-Apr | J. Int. Med. Res. | pmid:8243793 |
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
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| Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
| Nakazawa I et al. | Some features in prostaglandin synthesis of the cancer cells which metastasized into liver from intestinal cancer lesions. | 1993 | Tohoku J. Exp. Med. | pmid:8266326 |
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| Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
| Jaffar ZH and Pearce FL | Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells. | 1993 | Agents Actions | pmid:7511869 |
| Gyenes M and De Groot H | Prostanoid release by Kupffer cells upon hypoxia-reoxygenation: role of pHi and Cai2+. | 1993 | Am. J. Physiol. | pmid:8384798 |
| Twentyman OP et al. | The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8099592 |
| Satoh M and Yamazaki M | In vitro DNA synthesis of mouse hepatocytes stimulated by tumor necrosis factor is inhibited by glucocorticoids and prostaglandin D2 but enhanced by retinoic acid. | 1993 | J. Cell. Physiol. | pmid:8408229 |
| Bull HA et al. | Basophil mediator release in atopic dermatitis. | 1993 | J. Invest. Dermatol. | pmid:7680056 |
| Campbell AM et al. | Modulation of eicosanoid and histamine release from human dispersed lung cells by terfenadine. | 1993 | Allergy | pmid:7681268 |
| Maxwell DL et al. | Inhaled nedocromil sodium reduces histamine release from isolated large airway segments of asthmatic subjects in vivo. | 1993 | Eur. Respir. J. | pmid:7693506 |
| Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |