| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Le Loupp AG et al. | Activation of the prostaglandin D2 metabolic pathway in Crohn's disease: involvement of the enteric nervous system. | 2015 | BMC Gastroenterol | pmid:26338799 |
| Xu X et al. | Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism. | 2015 | Cell. Physiol. Biochem. | pmid:26279448 |
| Busse WW et al. | Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control. | 2015 | Chest | pmid:26226215 |
| Tsutsumi S et al. | Cerebrospinal fluid drainage through the diploic and spinal epidural veins. | 2015 | J. Anat. | pmid:26184099 |
| Jeon KI et al. | Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts. | 2015 | Exp. Eye Res. | pmid:26142957 |
| Cossette C et al. | Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. | 2015 | Biochem. Pharmacol. | pmid:26032638 |
| Maher SA et al. | Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events. | 2015 | Eur. Respir. J. | pmid:25323233 |
| Rossitto M et al. | Multiple roles of the prostaglandin D2 signaling pathway in reproduction. | 2015 | Reproduction | pmid:25269616 |
| Hyun J et al. | Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. | 2015 | J Innate Immun | pmid:25171731 |
| Walusinski O | How yawning switches the default-mode network to the attentional network by activating the cerebrospinal fluid flow. | 2014 | Clin Anat | pmid:23813685 |
| Cantley JL et al. | Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:25159329 |
| Savinainen JR et al. | Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL). | 2014 | Mol. Pharmacol. | pmid:25140003 |
| Dichlberger A et al. | Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. | 2014 | J. Lipid Res. | pmid:25114172 |
| Schäfer D et al. | Prostaglandin D2-supplemented "functional eicosanoid testing and typing" assay with peripheral blood leukocytes as a new tool in the diagnosis of systemic mast cell activation disease: an explorative diagnostic study. | 2014 | J Transl Med | pmid:25113638 |
| Huang HL et al. | 18F-glutathione conjugate as a PET tracer for imaging tumors that overexpress L-PGDS enzyme. | 2014 | PLoS ONE | pmid:25111383 |
| Bhargava S | Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer. | 2014 | Med. Hypotheses | pmid:24548754 |
| Yue L et al. | Prostaglandin D(2) induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways. | 2014 | Bone | pmid:24345643 |
| Han XQ et al. | Advanced glycation end products promote differentiation of CD4(+) T helper cells toward pro-inflammatory response. | 2014 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:24496672 |
| Pradhan A and Olsson PE | Juvenile ovary to testis transition in zebrafish involves inhibition of ptges. | 2014 | Biol. Reprod. | pmid:24920039 |
| Stenson WF | The universe of arachidonic acid metabolites in inflammatory bowel disease: can we tell the good from the bad? | 2014 | Curr. Opin. Gastroenterol. | pmid:24837228 |