| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arai I et al. | Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. | 2007 | Eur. J. Pharmacol. | pmid:17141215 |
| Chambers KT et al. | PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17148750 |
| Liu JJ et al. | Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. | 2007 | Ann. Hematol. | pmid:17089125 |
| Jin YR et al. | Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. | 2007 | Atherosclerosis | pmid:17092506 |
| Nicoll-Griffith DA et al. | In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17095220 |
| Hortobágyi L et al. | Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids. | 2007 | Brain Res. | pmid:17161389 |
| Kang MA et al. | Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. | 2007 | Life Sci. | pmid:17161435 |
| Sánchez-Gómez FJ et al. | Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. | 2007 | Arch. Biochem. Biophys. | pmid:17169324 |
| Huang ZL et al. | Prostaglandins and adenosine in the regulation of sleep and wakefulness. | 2007 | Curr Opin Pharmacol | pmid:17129762 |
| Kim HY and Kim HS | Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. | 2007 | Immunol. Cell Biol. | pmid:17130903 |
| Jung SM et al. | Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. | 2007 | Arthritis Res. Ther. | pmid:17612394 |
| Sugimoto M et al. | The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice. | 2007 | Eur. J. Pharmacol. | pmid:17328887 |
| Suwaki N et al. | Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. | 2007 | Placenta | pmid:16753211 |
| Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
| Ruano D et al. | Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia. | 2007 | Am. J. Med. Genet. B Neuropsychiatr. Genet. | pmid:17230501 |
| Rehan VK et al. | In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17215434 |
| Haack M et al. | Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. | 2007 | Sleep | pmid:17910386 |
| Mathew B et al. | Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17204585 |
| Gallant MA et al. | Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. | 2007 | Eur. J. Pharmacol. | pmid:17207480 |
| Xue L et al. | Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). | 2007 | Biochem. Pharmacol. | pmid:17196174 |
| Jin YR et al. | Antiplatelet effect of NQ12: a possible mechanism through the arachidonic acid cascade. | 2007 | J. Pharmacol. Sci. | pmid:17951980 |
| Van Hecken A et al. | The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers. | 2007 | Eur. J. Clin. Pharmacol. | pmid:17200838 |
| Moreira V et al. | Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases. | 2007 | Toxicon | pmid:17241651 |
| Liu M et al. | Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages. | 2007 | Neuroscience | pmid:17241746 |
| Tinfo N and Komar C | Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat. | 2007 | Reproduction | pmid:17244745 |
| Lee JH et al. | 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. | 2007 | J. Korean Med. Sci. | pmid:17982241 |
| Payne SG et al. | The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. | 2007 | Blood | pmid:17008548 |
| Li SJ et al. | [Effect of peroxisome proliferators-activated receptor gamma ligands on cytotrophoblast invasion in first trimester pregnancy]. | 2007 | Zhonghua Fu Chan Ke Za Zhi | pmid:17983488 |
| Porter DW et al. | PGJ2 inhibition of LPS-induced inflammatory mediator expression from rat alveolar macrophages. | 2007 | J. Toxicol. Environ. Health Part A | pmid:17966068 |
| Nitta N et al. | Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device -- TAXIScan. | 2007 | J. Immunol. Methods | pmid:17289072 |
| Reyes-Martin P et al. | Cyclooxygenase-independent inhibition of H2O2-induced cell death by S-ketoprofen in renal cells. | 2007 | Pharmacol. Res. | pmid:17291778 |
| Aldini G et al. | Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement. | 2007 | Biochemistry | pmid:17297918 |
| Pettipher R et al. | Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. | 2007 | Nat Rev Drug Discov | pmid:17396136 |
| Gayarre J et al. | Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17405918 |
| Ito W et al. | Hepatocyte growth factor attenuates eotaxin and PGD2-induced chemotaxis of human eosinophils. | 2007 | Allergy | pmid:17362253 |
| Yang WZ et al. | [The effect of ligand of peroxisome proliferators-activated receptor gamma 15d-PGJ2 on the proliferation and activation of hepatic stellate cells]. | 2007 | Zhonghua Gan Zang Bing Za Zhi | pmid:17362636 |
| Wilhelm D et al. | SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. | 2007 | J. Biol. Chem. | pmid:17277314 |
| Park JM et al. | Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. | 2007 | Cancer Res. | pmid:17283118 |
| Hammad H et al. | Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. | 2007 | J. Exp. Med. | pmid:17283205 |
| Kim HJ et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. | 2007 | Cancer Res. | pmid:17363578 |
| Yamada K et al. | Nose-to-brain delivery of TS-002, prostaglandin D2 analogue. | 2007 | J Drug Target | pmid:17365274 |
| Fionda C et al. | 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. | 2007 | J. Immunol. | pmid:17371958 |
| Saleem S et al. | PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury. | 2007 | Eur. J. Neurosci. | pmid:17573924 |
| Wu L et al. | Divergent effects of prostaglandin receptor signaling on neuronal survival. | 2007 | Neurosci. Lett. | pmid:17574754 |
| Hasegawa H et al. | A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. | 2007 | Blood | pmid:17551094 |
| Ueki S et al. | Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. | 2007 | Int. Arch. Allergy Immunol. | pmid:17541271 |
| Chiba T et al. | Possible novel receptor for PGD2 on human bronchial epithelial cells. | 2007 | Int. Arch. Allergy Immunol. | pmid:17541272 |
| Engdahl R et al. | 15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-alpha by decreasing levels of acetylated histone H3 and H4 at its promoter. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17532302 |
| Lin MS et al. | Activation of peroxisome proliferator-activated receptor gamma inhibits cell growth via apoptosis and arrest of the cell cycle in human colorectal cancer. | 2007 | J Dig Dis | pmid:17532820 |
| Futaki N et al. | Role of prostaglandins on mechanical scratching-induced cutaneous barrier disruption in mice. | 2007 | Exp. Dermatol. | pmid:17518991 |
| Aschenbach JR et al. | Functional characteristics of the porcine colonic epithelium following transportation stress and Salmonella infection. | 2007 | Scand. J. Gastroenterol. | pmid:17505993 |
| Wang XS et al. | PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease. | 2007 | Allergy | pmid:17508965 |
| Monroy MA et al. | THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. | 2007 | Shock | pmid:17510607 |
| Zingarelli B et al. | Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. | 2007 | Shock | pmid:17589386 |
| Vunta H et al. | The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. | 2007 | J. Biol. Chem. | pmid:17439952 |
| Taniguchi H et al. | Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. | 2007 | J. Neurosci. | pmid:17442814 |
| Zhang XC et al. | Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17483291 |
| Fulzele SV et al. | 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. | 2007 | Anticancer Drugs | pmid:17159504 |
| Richman JG et al. | Nicotinic acid receptor agonists differentially activate downstream effectors. | 2007 | J. Biol. Chem. | pmid:17452318 |
| Schütz TC et al. | Effects of COX-2 inhibitor in temporomandibular joint acute inflammation. | 2007 | J. Dent. Res. | pmid:17452571 |
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| Takeda K et al. | Neuroendocrine functions of melanocytes: beyond the skin-deep melanin maker. | 2007 | Tohoku J. Exp. Med. | pmid:17347546 |
| Mazid MA et al. | Development of enzyme-linked immunosorbent assay for prostaglandin D2 using the stable isosteric analogue as a hapten mimic and its application. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17481559 |
| Lim HJ et al. | 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17631927 |
| Olmos G et al. | Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. | 2007 | Cell. Signal. | pmid:17658243 |
| Xiang Z et al. | 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. | 2007 | J Neuroinflammation | pmid:17634127 |
| Ye Y et al. | Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17643887 |
| Desmarais JA et al. | The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). | 2007 | Biol. Reprod. | pmid:17615406 |
| Nagai H | [The role of lipid mediators in allergic diseases]. | 2007 | Arerugi | pmid:17615500 |
| Kaplan J et al. | Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. | 2007 | Shock | pmid:17621259 |
| Pierzchalska M et al. | Deficiency of cyclooxygenases transcripts in cultured primary bronchial epithelial cells of aspirin-sensitive asthmatics. | 2007 | J. Physiol. Pharmacol. | pmid:17622692 |
| Lin TH et al. | PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. | 2007 | Bone | pmid:17669705 |
| Fionda C et al. | Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes. | 2007 | Mol. Pharmacol. | pmid:17673570 |
| Joo M et al. | Induction and function of lipocalin prostaglandin D synthase in host immunity. | 2007 | J. Immunol. | pmid:17675519 |
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| Fournier T et al. | Involvement of PPARgamma in human trophoblast invasion. | 2007 | Placenta | pmid:17321592 |
| Rajakariar R et al. | Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077391 |
| Moulin D et al. | Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. | 2007 | Cytokine | pmid:18023358 |
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| Wang LH et al. | Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. | 2007 | Blood | pmid:17785586 |
| Han H et al. | 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. | 2007 | Apoptosis | pmid:17786557 |
| Yoon EK et al. | ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. | 2007 | J. Korean Med. Sci. | pmid:18162716 |
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| Wu P et al. | Inflammation pro-resolving potential of 3,4-dihydroxyacetophenone through 15-deoxy-delta12,14-prostaglandin J2 in murine macrophages. | 2007 | Int. Immunopharmacol. | pmid:17761349 |
| Saito Y et al. | Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. | 2007 | J. Neurochem. | pmid:17697048 |
| Iikura M et al. | IL-33 can promote survival, adhesion and cytokine production in human mast cells. | 2007 | Lab. Invest. | pmid:17700564 |
| Kondoh K et al. | Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apoptosis in cancer cells. | 2007 | Exp. Cell Res. | pmid:17706193 |
| Richard CL et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. | 2007 | Exp. Cell Res. | pmid:17707368 |
| Chen Y et al. | Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor. | 2007 | J. Immunol. | pmid:17709490 |
| Li Y et al. | Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist. | 2007 | J. Am. Chem. Soc. | pmid:17691773 |
| Parameswaran K et al. | Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17431098 |
| Rehan VK et al. | A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17435078 |
| Vinall SL et al. | A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes. | 2007 | Immunology | pmid:17437532 |
| Cossette C et al. | Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17041009 |
| Sandig H et al. | Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function. | 2007 | J. Leukoc. Biol. | pmid:17043246 |
| Kamagata C et al. | 15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. | 2007 | Breast Cancer Res. Treat. | pmid:17028981 |
| GarcÃa-Bueno B et al. | Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. | 2007 | Neuropsychopharmacology | pmid:17119541 |