15-deoxy-delta-12,14-PGJ2

15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.

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Introduction

To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-deoxy-delta-12,14-PGJ2?

15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2

MeSH term MeSH ID Detail
Graves Ophthalmopathy D049970 3 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Goiter D006042 4 associated lipids
Actinobacillus Infections D000189 4 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Myocardial Infarction D009203 21 associated lipids
Fibrosis D005355 23 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Per page 10 20 50 | Total 30

PubChem Associated disorders and diseases

What pathways are associated with 15-deoxy-delta-12,14-PGJ2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 15-deoxy-delta-12,14-PGJ2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 15-deoxy-delta-12,14-PGJ2

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Per page 10 20 50 100 | Total 940
Authors Title Published Journal PubMed Link
Higashihara H et al. Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. 2004 Redox Rep. pmid:15720834
Takagi T et al. A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. 2004 Redox Rep. pmid:15720836
Storer PD et al. Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. 2005 J. Neurosci. Res. pmid:15723383
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Andrews WJ et al. Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. 2005 J. Steroid Biochem. Mol. Biol. pmid:15862961
Allred CD and Kilgore MW Selective activation of PPARgamma in breast, colon, and lung cancer cell lines. 2005 Mol. Cell. Endocrinol. pmid:15866424
Marzocco S et al. The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock. 2005 Intensive Care Med pmid:15868139
Maurin AC et al. Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. 2005 Calcif. Tissue Int. pmid:15868283
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De Oliveira C et al. Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. 2005 J. Lab. Clin. Med. pmid:15871306
Planagumà A et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. 2005 FASEB J. pmid:15876570
Kim HY et al. Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. 2005 Immunol. Cell Biol. pmid:15877607
Blanco M et al. Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke. 2005 Stroke pmid:15879329
Marchini C et al. Aspirin modulates LPS-induced nitric oxide release in rat glial cells. 2005 Jun 10-17 Neurosci. Lett. pmid:15882795
Artwohl M et al. Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. 2005 Thromb. Haemost. pmid:15886792
Capobianco E et al. 15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. 2005 Reprod. Fertil. Dev. pmid:15899154
Han S et al. Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15908479
Hosoya T et al. Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. 2005 J. Biol. Chem. pmid:15917255
Nakanishi T et al. Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. 2005 Mol. Endocrinol. pmid:15941851
Tomita H et al. Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. 2005 Cardiovasc. Res. pmid:15949477
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Kim HJ et al. 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. 2005 Exp. Mol. Med. pmid:16000871
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Eggler AL et al. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16006525
Matsuzaki Y et al. 15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. 2005 Int. J. Oncol. pmid:16010433
Polikandriotis JA et al. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:16020752
Pereira MP et al. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. 2006 J. Cereb. Blood Flow Metab. pmid:16034372
Unno Y et al. Glycolaldehyde-modified bovine serum albumin downregulates leptin expression in mouse adipocytes via a CD36-mediated pathway. 2005 Ann. N. Y. Acad. Sci. pmid:16037295