| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
15-deoxy-delta-12,14-PGJ2
15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-deoxy-delta-12,14-PGJ2?
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
PubChem Associated disorders and diseases
What pathways are associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 15-deoxy-delta-12,14-PGJ2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Su RY et al. | 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. | 2008 | Mol. Cancer Ther. | pmid:18852146 |
| Nagata D et al. | Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. | 2008 | Cancer Detect. Prev. | pmid:18789607 |
| Cruz-Orengo L et al. | Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. | 2008 | Mol Pain | pmid:18671867 |
| Oku H and Umino T | Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major. | 2008 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:18691667 |
| Kim EH and Surh YJ | The role of 15-deoxy-delta(12,14)-prostaglandin J(2), an endogenous ligand of peroxisome proliferator-activated receptor gamma, in tumor angiogenesis. | 2008 | Biochem. Pharmacol. | pmid:18771658 |
| Kim JW et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2. | 2008 | Biochem. Pharmacol. | pmid:18775681 |
| Ho TC et al. | 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53. | 2008 | J. Biol. Chem. | pmid:18718914 |
| Jozkowicz A et al. | 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. | 2008 | Antioxid. Redox Signal. | pmid:18665800 |
| Napimoga MH et al. | Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway. | 2008 | J. Immunol. | pmid:18097063 |
| Muñoz U et al. | On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. | 2008 | Cell. Mol. Life Sci. | pmid:18818877 |
| Kuboki S et al. | Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in mice. | 2008 | Hepatology | pmid:18085707 |
| Lutzow YS et al. | 15-Deoxy-Delta12,14-prostaglandin J2 induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells. | 2008 | J. Dairy Res. | pmid:18226310 |
| Kerr BJ et al. | The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury. | 2008 | Glia | pmid:18205174 |
| Choi IK et al. | PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. | 2008 | Invest New Drugs | pmid:18161004 |
| Hounoki H et al. | Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. | 2008 | Bone | pmid:18242157 |
| Kim EH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. | 2008 | Carcinogenesis | pmid:18192694 |
| Crabb SJ et al. | BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells. | 2008 | Oncol. Rep. | pmid:18288403 |
| Hong HY et al. | Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-delta 12,14-prostaglandin J2 in murine macrophages. | 2008 | FEBS Lett. | pmid:18291107 |
| Kimura H et al. | A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions. | 2008 | Nephrol. Dial. Transplant. | pmid:18367541 |
| Kang MA et al. | Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. | 2007 | Life Sci. | pmid:17161435 |
| Sánchez-Gómez FJ et al. | Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. | 2007 | Arch. Biochem. Biophys. | pmid:17169324 |
| Kim HY and Kim HS | Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. | 2007 | Immunol. Cell Biol. | pmid:17130903 |
| Tanaka Y et al. | Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. | 2007 | Mol. Pharmacol. | pmid:17151289 |
| Suwaki N et al. | Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. | 2007 | Placenta | pmid:16753211 |
| Lee JH et al. | 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. | 2007 | J. Korean Med. Sci. | pmid:17982241 |
| Li SJ et al. | [Effect of peroxisome proliferators-activated receptor gamma ligands on cytotrophoblast invasion in first trimester pregnancy]. | 2007 | Zhonghua Fu Chan Ke Za Zhi | pmid:17983488 |
| Reyes-Martin P et al. | Cyclooxygenase-independent inhibition of H2O2-induced cell death by S-ketoprofen in renal cells. | 2007 | Pharmacol. Res. | pmid:17291778 |
| Gayarre J et al. | Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17405918 |
| Li X et al. | Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells. | 2007 | Nephrol. Dial. Transplant. | pmid:17255125 |
| Yang WZ et al. | [The effect of ligand of peroxisome proliferators-activated receptor gamma 15d-PGJ2 on the proliferation and activation of hepatic stellate cells]. | 2007 | Zhonghua Gan Zang Bing Za Zhi | pmid:17362636 |
| Kim HJ et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. | 2007 | Cancer Res. | pmid:17363578 |
| Fionda C et al. | 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. | 2007 | J. Immunol. | pmid:17371958 |
| Ueki S et al. | Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. | 2007 | Int. Arch. Allergy Immunol. | pmid:17541271 |
| Fulzele SV et al. | 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. | 2007 | Anticancer Drugs | pmid:17159504 |
| Olmos G et al. | Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. | 2007 | Cell. Signal. | pmid:17658243 |
| Lin TH et al. | PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. | 2007 | Bone | pmid:17669705 |
| Fionda C et al. | Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes. | 2007 | Mol. Pharmacol. | pmid:17673570 |
| Chintalgattu V et al. | PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts. | 2007 | Cardiovasc. Res. | pmid:17320065 |
| Fournier T et al. | Involvement of PPARgamma in human trophoblast invasion. | 2007 | Placenta | pmid:17321592 |
| Rajakariar R et al. | Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077391 |
| Mizutani N et al. | Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. | 2007 | J. Immunol. | pmid:18025192 |
| Kim WJ et al. | Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. | 2007 | EMBO J. | pmid:18034160 |
| Haworth O and Buckley CD | Resolving the problem of persistence in the switch from acute to chronic inflammation. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18093938 |
| Han H et al. | 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. | 2007 | Apoptosis | pmid:17786557 |
| Brunoldi EM et al. | Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. | 2007 | Chem. Res. Toxicol. | pmid:17854155 |
| Wu P et al. | Inflammation pro-resolving potential of 3,4-dihydroxyacetophenone through 15-deoxy-delta12,14-prostaglandin J2 in murine macrophages. | 2007 | Int. Immunopharmacol. | pmid:17761349 |
| Saito Y et al. | Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. | 2007 | J. Neurochem. | pmid:17697048 |
| Kondoh K et al. | Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apoptosis in cancer cells. | 2007 | Exp. Cell Res. | pmid:17706193 |
| Richard CL et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. | 2007 | Exp. Cell Res. | pmid:17707368 |
| Kamagata C et al. | 15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. | 2007 | Breast Cancer Res. Treat. | pmid:17028981 |