| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
15-deoxy-delta-12,14-PGJ2
15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-deoxy-delta-12,14-PGJ2?
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
PubChem Associated disorders and diseases
What pathways are associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 15-deoxy-delta-12,14-PGJ2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Da Silva Morais A et al. | Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice. | 2007 | Int. J. Mol. Med. | pmid:17143554 |
| Hagens WI et al. | Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. | 2007 | Pharm. Res. | pmid:17245650 |
| Yang C et al. | Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. | 2007 | Am. J. Pathol. | pmid:17255338 |
| Li CF et al. | [Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. | 2007 | Beijing Da Xue Xue Bao | pmid:17304332 |
| Hasegawa H et al. | A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. | 2007 | Blood | pmid:17551094 |
| Engdahl R et al. | 15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-alpha by decreasing levels of acetylated histone H3 and H4 at its promoter. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17532302 |
| Monroy MA et al. | THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. | 2007 | Shock | pmid:17510607 |
| Zingarelli B et al. | Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. | 2007 | Shock | pmid:17589386 |
| Vunta H et al. | The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. | 2007 | J. Biol. Chem. | pmid:17439952 |
| Ponferrada A et al. | The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. | 2007 | Gastroenterology | pmid:17484875 |
| Cerbone A et al. | 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. | 2007 | Free Radic. Biol. Med. | pmid:17462534 |
| Yano M et al. | Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. | 2007 | Circ. Res. | pmid:17463321 |
| Arnold R et al. | Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. | 2007 | Immunology | pmid:17425601 |
| Zhao X et al. | Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. | 2007 | Ann. Neurol. | pmid:17457822 |
| Berry A et al. | IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. | 2007 | Eur. J. Immunol. | pmid:17458857 |
| Lim HJ et al. | 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17631927 |
| Xiang Z et al. | 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. | 2007 | J Neuroinflammation | pmid:17634127 |
| Ye Y et al. | Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17643887 |
| Desmarais JA et al. | The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). | 2007 | Biol. Reprod. | pmid:17615406 |
| Kaplan J et al. | Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. | 2007 | Shock | pmid:17621259 |
| Paukkeri EL et al. | PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. | 2007 | Br. J. Pharmacol. | pmid:17891158 |
| Lin TH et al. | PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. | 2007 | Bone | pmid:17669705 |
| Fionda C et al. | Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes. | 2007 | Mol. Pharmacol. | pmid:17673570 |
| Ou YC et al. | Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. | 2007 | Eur. J. Pharmacol. | pmid:17341418 |
| Schlezinger JJ et al. | An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells. | 2007 | Toxicol. Sci. | pmid:17400580 |
| Kim KY et al. | Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. | 2007 | Mol. Pharmacol. | pmid:17535976 |
| Yoon EK et al. | ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. | 2007 | J. Korean Med. Sci. | pmid:18162716 |
| Cao LQ et al. | [15-deoxy-Delta(12,14)-prostaglandin J(2) induces anoikis of hepatocellular carcinoma cells: an in vitro experiment]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:18261336 |
| Rollins MD et al. | Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. | 2006 Sep-Oct | J. Gastrointest. Surg. | pmid:16966031 |
| Lappas M et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. | 2006 Nov-Dec | Placenta | pmid:16434095 |
| Zhang A et al. | Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16896186 |
| Chaffer CL et al. | PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. | 2006 | BMC Cancer | pmid:16519808 |
| Funovics P et al. | Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647637 |
| Rockwell CE et al. | Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. | 2006 | Mol. Pharmacol. | pmid:16611855 |
| Arnold R and König W | Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. | 2006 | Virology | pmid:16616290 |
| Kobayashi M et al. | ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. | 2006 | Genes Cells | pmid:16824197 |
| Zhang M et al. | Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. | 2006 | Int. Immunopharmacol. | pmid:16782535 |
| Chen Y et al. | Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. | 2006 | J. Cell. Biochem. | pmid:16795079 |
| Yucel-Lindberg T et al. | Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. | 2006 | Cell. Signal. | pmid:16766159 |
| Relic B et al. | Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. | 2006 | J. Biol. Chem. | pmid:16766531 |
| Hickson-Bick DL et al. | The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. | 2006 | Shock | pmid:16680021 |
| Sun K et al. | PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. | 2006 | Acta Pharmacol. Sin. | pmid:16723090 |
| Ou Z et al. | Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2--mediated protection of brain after experimental cerebral ischemia in rat. | 2006 | Brain Res. | pmid:16725118 |
| Lee S et al. | Rosiglitazone ameliorates cisplatin-induced renal injury in mice. | 2006 | Nephrol. Dial. Transplant. | pmid:16728429 |
| Rajasingh J and Bright JJ | 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells. | 2006 | Exp. Cell Res. | pmid:16737695 |
| Millán O et al. | Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. | 2006 | Carcinogenesis | pmid:16113051 |
| Kim EH et al. | Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17384282 |
| Ciucci A et al. | Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. | 2006 | Mol. Pharmacol. | pmid:16908599 |
| Nakahata Y et al. | The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. | 2006 | BMC Mol. Biol. | pmid:16483373 |
| Yeh CH et al. | Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. | 2006 | Shock | pmid:16912651 |