| MeSH term | MeSH ID | Detail |
|---|---|---|
| Actinobacillus Infections | D000189 | 4 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Goiter | D006042 | 4 associated lipids |
15-deoxy-delta-12,14-PGJ2
15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-deoxy-delta-12,14-PGJ2?
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
PubChem Associated disorders and diseases
What pathways are associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 15-deoxy-delta-12,14-PGJ2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Downie MM et al. | Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 | Br. J. Dermatol. | pmid:15491415 |
| Ray DM et al. | Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. | 2004 | Clin. Immunol. | pmid:15451478 |
| Abdelrahman M et al. | The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. | 2004 | Shock | pmid:15545828 |
| Chen Q et al. | A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. | 2004 | Anal. Biochem. | pmid:15556564 |
| Józkowicz A et al. | 15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560113 |
| Emi M and Maeyama K | The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. | 2004 | Biochem. Pharmacol. | pmid:15013841 |
| Diab A et al. | Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. | 2004 | J. Neuroimmunol. | pmid:14975592 |
| Paumi CM et al. | Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). | 2004 | Biochemistry | pmid:14979731 |
| Cheng S et al. | Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. | 2004 | J. Biol. Chem. | pmid:15023995 |
| Alvarez-Maqueda M et al. | 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. | 2004 | J. Biol. Chem. | pmid:15024026 |
| Hashimoto K et al. | Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. | 2004 | Pancreas | pmid:15028947 |
| Relic B et al. | 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. | 2004 | J. Biol. Chem. | pmid:15004016 |
| Konopleva M et al. | Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. | 2004 | Mol. Cancer Ther. | pmid:15486192 |
| Ishii T and Uchida K | Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. | 2004 | Chem. Res. Toxicol. | pmid:15487891 |
| Liu JD et al. | Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. | 2004 | Life Sci. | pmid:14998722 |
| Eucker J et al. | Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. | 2004 | Anticancer Drugs | pmid:15514564 |
| Giri S et al. | The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. | 2004 | J. Immunol. | pmid:15470065 |
| Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
| Lee KJ et al. | Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. | 2004 | Exp. Mol. Med. | pmid:15665586 |
| Maddox JF et al. | 15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes. | 2004 | Toxicol. Sci. | pmid:14657518 |
| Asada K et al. | Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14563653 |
| Ehara N et al. | Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358182 |
| Ichiki T et al. | 15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15369766 |
| Morosetti R et al. | The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. | 2004 | Int. J. Oncol. | pmid:15254749 |
| Park KS et al. | Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. | 2004 | Exp. Cell Res. | pmid:15212945 |
| Han S et al. | Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression. | 2004 | Chest | pmid:15136464 |
| Collin M et al. | Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin. | 2004 | Crit. Care Med. | pmid:15090969 |
| Zang C et al. | Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. | 2004 | Leuk. Res. | pmid:15109539 |
| Moore RM et al. | Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. | 2003 Feb-Mar | Placenta | pmid:12566244 |
| Ceaser EK et al. | Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12881207 |
| Pritts EA et al. | Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element. | 2003 | Fertil. Steril. | pmid:12909507 |
| Zhang M et al. | [Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-gamma and its mechanism]. | 2003 | Zhonghua Yi Xue Za Zhi | pmid:12921638 |
| Li L et al. | Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. | 2003 | Gastroenterology | pmid:12891549 |
| Houston KD et al. | Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. | 2003 | Cancer Res. | pmid:12649180 |
| Kim BE et al. | Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2. | 2003 | Exp. Mol. Med. | pmid:14508070 |
| Lee TS et al. | Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. | 2003 | J. Biol. Chem. | pmid:12642589 |
| Fukuchi K et al. | Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. | 2003 | J. Dent. Res. | pmid:14514760 |
| Kim EJ et al. | Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12966153 |
| Collin M and Thiemermann C | The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock. | 2003 | Eur. J. Pharmacol. | pmid:12969773 |
| Farrow B et al. | Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator. | 2003 | Surgery | pmid:12947319 |
| Powell WS | 15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product? | 2003 | J. Clin. Invest. | pmid:12975467 |
| Bell-Parikh LC et al. | Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. | 2003 | J. Clin. Invest. | pmid:12975479 |
| Kanbe E et al. | DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand. | 2003 | Exp. Hematol. | pmid:12691917 |
| Zernecke A et al. | Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction. | 2003 | FASEB J. | pmid:12692090 |
| Garg TK and Chang JY | Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. | 2003 | BMC Ophthalmol | pmid:12659653 |
| Castaño E and Gil J | 15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. | 2003 | J. Cell. Physiol. | pmid:12704651 |
| Faveeuw C et al. | Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. | 2003 | Eur. J. Immunol. | pmid:12672054 |
| Oliva JL et al. | The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12684535 |
| Abe M et al. | GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615657 |
| Wanichkul T et al. | Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. | 2003 | Fertil. Steril. | pmid:12620489 |