| MeSH term | MeSH ID | Detail |
|---|---|---|
| Actinobacillus Infections | D000189 | 4 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Goiter | D006042 | 4 associated lipids |
15-deoxy-delta-12,14-PGJ2
15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-deoxy-delta-12,14-PGJ2?
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
PubChem Associated disorders and diseases
What pathways are associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 15-deoxy-delta-12,14-PGJ2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mazid MA et al. | Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. | 2006 | FEBS Lett. | pmid:17150216 |
| Kang DS et al. | 15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16890972 |
| Nakata S et al. | 15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. | 2006 | Mol. Cancer Ther. | pmid:16891469 |
| Zhang A et al. | Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16896186 |
| Chaffer CL et al. | PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. | 2006 | BMC Cancer | pmid:16519808 |
| Fu YG et al. | Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1. | 2006 | Cancer Lett. | pmid:16412567 |
| Wung BS et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. | 2006 | Life Sci. | pmid:16413037 |
| Funovics P et al. | Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647637 |
| Hauser B et al. | Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia. | 2006 | Intensive Care Med | pmid:16534570 |
| Rockwell CE et al. | Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. | 2006 | Mol. Pharmacol. | pmid:16611855 |
| Arnold R and König W | Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. | 2006 | Virology | pmid:16616290 |
| Arnold R and König W | Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. | 2006 | Virology | pmid:16330064 |
| Kohno S et al. | Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma. | 2006 | Biomed. Pharmacother. | pmid:16337105 |
| Xie Y et al. | Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins. | 2006 | Diabetes Obes Metab | pmid:16367886 |
| Lin TN et al. | 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16385084 |
| Kobayashi M et al. | ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. | 2006 | Genes Cells | pmid:16824197 |
| Landar A et al. | Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16387790 |
| Chen Y et al. | Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. | 2006 | J. Cell. Biochem. | pmid:16795079 |
| Relic B et al. | Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. | 2006 | J. Biol. Chem. | pmid:16766531 |
| Yasugi E et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells. | 2006 | Dev. Growth Differ. | pmid:16573735 |
| Stamatakis K et al. | Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. | 2006 | J. Am. Soc. Nephrol. | pmid:16291835 |
| Zhao X et al. | 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16208315 |
| Landar A et al. | Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. | 2006 | Biochem. J. | pmid:16268779 |
| Garg TK and Chang JY | Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. | 2006 | J. Neuroimmunol. | pmid:16225932 |
| Shiraki T et al. | Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. | 2006 | Biochem. J. | pmid:16236024 |
| Benkirane K et al. | PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16155101 |
| Cho WH et al. | 15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. | 2006 | Neurochem. Res. | pmid:17006759 |
| Pereira MP et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16034372 |
| Tanaka H et al. | Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives. | 2006 | Chem Asian J | pmid:17441107 |
| Gayarre J et al. | Addition of electrophilic lipids to actin alters filament structure. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16979589 |
| Zhang YJ et al. | Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). | 2006 | Am. J. Nephrol. | pmid:16864989 |
| Ciucci A et al. | Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. | 2006 | Mol. Pharmacol. | pmid:16908599 |
| Eucker J et al. | Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. | 2006 | Anticancer Drugs | pmid:16926626 |
| Raikwar HP et al. | PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. | 2006 | J. Neuroimmunol. | pmid:16844232 |
| Willermain F et al. | 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939878 |
| Lim HJ et al. | PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939881 |
| Yu X et al. | Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. | 2006 | J. Biol. Chem. | pmid:16857669 |
| Coyle AT and Kinsella BT | Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16499875 |
| Makino N et al. | Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia. | 2006 | Cell Biochem. Biophys. | pmid:16456235 |
| Belvisi MG et al. | Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation. | 2006 | Eur. J. Pharmacol. | pmid:16458290 |
| Masuda H et al. | 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. | 2006 | Urology | pmid:16461118 |
| Nakahata Y et al. | The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. | 2006 | BMC Mol. Biol. | pmid:16483373 |
| Kang HY et al. | Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. | 2006 | Arch. Dermatol. Res. | pmid:16474974 |
| Schröder O et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. | 2006 | J. Lipid Res. | pmid:16495511 |
| Piraino G et al. | Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. | 2006 | Shock | pmid:16878022 |
| Moulin D et al. | Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. | 2006 | Biorheology | pmid:16912428 |
| Yeh CH et al. | Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. | 2006 | Shock | pmid:16912651 |
| Ye F et al. | Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. | 2006 | Cell. Physiol. Biochem. | pmid:16914899 |
| Kim EH and Surh YJ | 15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors. | 2006 | Biochem. Pharmacol. | pmid:16987499 |
| Qin S et al. | Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065531 |