| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Graves Ophthalmopathy | D049970 | 3 associated lipids |
| Lymphoma, T-Cell | D016399 | 11 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia, B-Cell | D015448 | 3 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
15-deoxy-delta-12,14-PGJ2
15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-deoxy-delta-12,14-PGJ2?
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
PubChem Associated disorders and diseases
What pathways are associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 15-deoxy-delta-12,14-PGJ2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sawai H et al. | Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. | 2006 | Mol. Cancer Res. | pmid:16547153 |
| Huang H et al. | Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. | 2004 | Mol. Cancer Res. | pmid:15498928 |
| Kim YI et al. | Effects of 15-deoxy-∆¹²,¹â´-prostaglandin Jâ‚‚ on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. | 2011 | Mol. Biol. Rep. | pmid:20174873 |
| Weng Y et al. | Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. | 2012 | Mol Pain | pmid:23013719 |
| Cruz-Orengo L et al. | Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. | 2008 | Mol Pain | pmid:18671867 |
| Fain JN et al. | Regulation of leptin release by troglitazone in human adipose tissue. | 2000 | Metab. Clin. Exp. | pmid:11092516 |
| Sinha D et al. | 15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene. | 1999 | Metab. Clin. Exp. | pmid:10381155 |
| Rodrigues WF et al. | 15d-PGJ(2) modulates acute immune responses to Trypanosoma cruzi infection. | 2010 | Mem. Inst. Oswaldo Cruz | pmid:20428671 |
| Sykes L et al. | Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. | 2012 | Mediators Inflamm. | pmid:22690041 |
| Carregaro V et al. | Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25-FOXP3+ Cells. | 2016 | Mediators Inflamm. | pmid:27872515 |
| Nozaki Y et al. | PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. | 2013 | Med Mol Morphol | pmid:23397546 |
| Kim HJ et al. | ROSics: chemistry and proteomics of cysteine modifications in redox biology. | 2015 Mar-Apr | Mass Spectrom Rev | pmid:24916017 |
| Date M et al. | 15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells. | 2003 | Liver Int. | pmid:14986820 |
| Gressner OA et al. | Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. | 2009 | Liver Int. | pmid:19018984 |
| Kang MA et al. | Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. | 2007 | Life Sci. | pmid:17161435 |
| Wung BS et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. | 2006 | Life Sci. | pmid:16413037 |
| Shirahase H et al. | Inhibitory effects of PGD2, PGJ2 and 15-deoxy-delta12,14-PGJ2 on iNOS induction in rat mesenteric artery. | 2000 | Life Sci. | pmid:10834301 |
| Liu JD et al. | Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. | 2004 | Life Sci. | pmid:14998722 |
| Stebulis JA et al. | Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells. | 2008 | Life Sci. | pmid:18840450 |
| Clemente-Napimoga JT et al. | 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. | 2012 | Life Sci. | pmid:22564409 |
| Jung WK et al. | The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. | 2009 | Life Sci. | pmid:19409914 |
| Kattamuri PV et al. | Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity. | 2013 | Life Sci. | pmid:22820546 |
| Hayden RE et al. | Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. | 2009 | Leukemia | pmid:18923439 |
| Zang C et al. | Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. | 2004 | Leuk. Res. | pmid:15109539 |
| Okano H et al. | 15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. | 2003 | Lab. Invest. | pmid:14563954 |
| Chung YW et al. | [Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells]. | 2003 | Korean J Gastroenterol | pmid:14532729 |
| Rovin BH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death. | 2002 | Kidney Int. | pmid:11918736 |
| Sawano H et al. | 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. | 2002 | Kidney Int. | pmid:12028436 |
| Stahlschmidt J et al. | Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. | 2005 | Kidney Int. | pmid:16105033 |
| Zhang X et al. | Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells. | 2004 | Kidney Int. | pmid:14871400 |
| Ueta M et al. | PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. | 2004 | Kidney Int. | pmid:14871416 |
| Chana RS et al. | Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. | 2004 | Kidney Int. | pmid:15149321 |
| Calabrò P et al. | Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. | 2005 Nov-Dec | J. Vasc. Res. | pmid:16155367 |
| Hong JT et al. | Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. | 2002 | J. Toxicol. Environ. Health Part A | pmid:11936221 |
| Moraes LA et al. | Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. | 2010 | J. Thromb. Haemost. | pmid:20040043 |
| O'Brien JJ et al. | 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. | 2009 | J. Thromb. Haemost. | pmid:18983509 |
| Byrns MC et al. | Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20036328 |
| Davidson J et al. | 7beta-hydroxy-epiandrosterone modulation of 15-deoxy-delta12,14-prostaglandin J2, prostaglandin D2 and prostaglandin E2 production from human mononuclear cells. | 2008 | J. Steroid Biochem. Mol. Biol. | pmid:18996481 |
| Andrews WJ et al. | Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862961 |
| Li X et al. | Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. | 2005 | J. Rheumatol. | pmid:15868626 |
| Viergutz T et al. | Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor gamma protein in bovine large lutein cells. | 2000 | J. Reprod. Fertil. | pmid:10793637 |
| Cha B et al. | 15-deoxy-D12,14-prostaglandin J2 suppresses RANTES expression by inhibiting NADPH oxidase activation in Helicobacter pylori-infected gastric epithelial cells. | 2011 | J. Physiol. Pharmacol. | pmid:21673364 |
| Korolczuk A et al. | The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity. | 2014 | J. Physiol. Pharmacol. | pmid:25554991 |
| Abdo H et al. | The omega-6 fatty acid derivative 15-deoxy-Δ¹²,¹â´-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress. | 2012 | J. Physiol. (Lond.) | pmid:22473776 |
| Bach-Ngohou K et al. | Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. | 2010 | J. Physiol. (Lond.) | pmid:20478974 |
| Hatanaka M et al. | 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. | 2010 | J. Pharmacol. Sci. | pmid:20424389 |
| Azuma Y et al. | Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1. | 2004 | J. Pharmacol. Sci. | pmid:15037811 |
| Takata K et al. | Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. | 2003 | J. Pharmacol. Sci. | pmid:12719662 |
| Kim EJ et al. | Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12966153 |
| Shimomura K et al. | Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15201343 |