15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rossi A et al. | Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. | 2000 | Nature | pmid:10638762 |
Clark RB et al. | The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. | 2000 | J. Immunol. | pmid:10640751 |
Davies GF et al. | Troglitazone induces expression of PPARgamma in liver. | 1999 Sep-Dec | Mol. Cell Biol. Res. Commun. | pmid:10662598 |
Castrillo A et al. | Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages. | 2000 | Mol. Cell. Biol. | pmid:10669746 |
Butler R et al. | Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2. | 2000 | Cell Growth Differ. | pmid:10672903 |
Sugiyama H et al. | Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells. | 2000 | FEBS Lett. | pmid:10675550 |
Rubin GL et al. | Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy. | 2000 | Cancer Res. | pmid:10749129 |
Tsubouchi Y et al. | Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753637 |
Kawamoto Y et al. | Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-delta(12,14)-prostaglandin j2-induced expression of glutathione S-transferases. | 2000 | J. Biol. Chem. | pmid:10753940 |
Straus DS et al. | 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781090 |
Feng J et al. | Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. | 2000 | J. Lipid Res. | pmid:10787429 |
Viergutz T et al. | Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor gamma protein in bovine large lutein cells. | 2000 | J. Reprod. Fertil. | pmid:10793637 |
Taba Y et al. | Fluid shear stress induces lipocalin-type prostaglandin D(2) synthase expression in vascular endothelial cells. | 2000 | Circ. Res. | pmid:10807869 |
Goetze S et al. | Troglitazone inhibits mitogenic signaling by insulin in vascular smooth muscle cells. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10813377 |
Padilla J et al. | PPAR-gamma-mediated regulation of normal and malignant B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818446 |
Padilla J et al. | Effects of 15-deoxy-delta 12,14-PGJ2 on B lineage cells. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818475 |
Inoue H et al. | Feedback control of cyclooxygenase-2 expression through PPARgamma. | 2000 | J. Biol. Chem. | pmid:10827178 |
Wächtershäuser A et al. | PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833422 |
Shirahase H et al. | Inhibitory effects of PGD2, PGJ2 and 15-deoxy-delta12,14-PGJ2 on iNOS induction in rat mesenteric artery. | 2000 | Life Sci. | pmid:10834301 |
Koppal T et al. | Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. | 2000 | Brain Res. | pmid:10837804 |