15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mazid MA et al. | Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. | 2006 | FEBS Lett. | pmid:17150216 |
Chaffer CL et al. | PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. | 2006 | BMC Cancer | pmid:16519808 |
Sawai H et al. | Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. | 2006 | Mol. Cancer Res. | pmid:16547153 |
Fu YG et al. | Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1. | 2006 | Cancer Lett. | pmid:16412567 |
Wung BS et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. | 2006 | Life Sci. | pmid:16413037 |
Funovics P et al. | Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647637 |
Antoun J et al. | CYP4A11 is repressed by retinoic acid in human liver cells. | 2006 | FEBS Lett. | pmid:16712844 |
Hauser B et al. | Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia. | 2006 | Intensive Care Med | pmid:16534570 |
Lee SJ et al. | Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephosphorylation. | 2006 | Mol. Pharmacol. | pmid:16611854 |
Rockwell CE et al. | Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. | 2006 | Mol. Pharmacol. | pmid:16611855 |
Arnold R and König W | Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. | 2006 | Virology | pmid:16616290 |
Merwald H et al. | Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. | 2006 | Cell Stress Chaperones | pmid:16572732 |
Arnold R and König W | Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. | 2006 | Virology | pmid:16330064 |
Kohno S et al. | Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma. | 2006 | Biomed. Pharmacother. | pmid:16337105 |
Xie Y et al. | Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins. | 2006 | Diabetes Obes Metab | pmid:16367886 |
Lin TN et al. | 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16385084 |
Landar A et al. | Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16387790 |
Na HK and Surh YJ | Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection. | 2006 | Mol. Carcinog. | pmid:16673384 |
Hickson-Bick DL et al. | The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. | 2006 | Shock | pmid:16680021 |
Sun K et al. | PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. | 2006 | Acta Pharmacol. Sin. | pmid:16723090 |
Ou Z et al. | Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2--mediated protection of brain after experimental cerebral ischemia in rat. | 2006 | Brain Res. | pmid:16725118 |
Lee S et al. | Rosiglitazone ameliorates cisplatin-induced renal injury in mice. | 2006 | Nephrol. Dial. Transplant. | pmid:16728429 |
Rajasingh J and Bright JJ | 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells. | 2006 | Exp. Cell Res. | pmid:16737695 |
Yasugi E et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells. | 2006 | Dev. Growth Differ. | pmid:16573735 |
Cuzzocrea S | Peroxisome proliferator-activated receptors and acute lung injury. | 2006 | Curr Opin Pharmacol | pmid:16580256 |
Suzuki T et al. | Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions. | 2006 | Endocr. Relat. Cancer | pmid:16601291 |
Stamatakis K et al. | Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. | 2006 | J. Am. Soc. Nephrol. | pmid:16291835 |
Shiraki T et al. | Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. | 2006 | Biochem. J. | pmid:16236024 |
Benkirane K et al. | PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16155101 |
Zhang YF et al. | Peroxisome proliferator-activated receptor-gamma is expressed by rat peritoneal mesothelial cells: its potential role in peritoneal cavity local defense. | 2006 | Am. J. Nephrol. | pmid:17183189 |
Cho WH et al. | 15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. | 2006 | Neurochem. Res. | pmid:17006759 |
Pereira MP et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. | 2006 | J. Cereb. Blood Flow Metab. | pmid:16034372 |
Kim EH et al. | Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. | 2006 | Ann. N. Y. Acad. Sci. | pmid:17384282 |
Núñez NP et al. | PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. | 2006 | Cancer Lett. | pmid:15979236 |
Gayarre J et al. | Addition of electrophilic lipids to actin alters filament structure. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16979589 |
Raikwar HP et al. | PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. | 2006 | J. Neuroimmunol. | pmid:16844232 |
Willermain F et al. | 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939878 |
Lim HJ et al. | PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939881 |
Chen ZH et al. | Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. | 2006 | J. Biol. Chem. | pmid:16565077 |
Coyle AT and Kinsella BT | Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16499875 |
Makino N et al. | Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia. | 2006 | Cell Biochem. Biophys. | pmid:16456235 |
Belvisi MG et al. | Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation. | 2006 | Eur. J. Pharmacol. | pmid:16458290 |
Masuda H et al. | 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. | 2006 | Urology | pmid:16461118 |
Nakahata Y et al. | The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. | 2006 | BMC Mol. Biol. | pmid:16483373 |
Kang HY et al. | Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. | 2006 | Arch. Dermatol. Res. | pmid:16474974 |
Schröder O et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. | 2006 | J. Lipid Res. | pmid:16495511 |
Wung BS et al. | Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. | 2006 | Pharmacol. Res. | pmid:16243536 |
Yeh CH et al. | Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. | 2006 | Shock | pmid:16912651 |
Kim EH and Surh YJ | 15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors. | 2006 | Biochem. Pharmacol. | pmid:16987499 |
Qin S et al. | Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065531 |