15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Napimoga MH et al. | Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. | 2012 | J. Immunol. | pmid:22706081 |
Kattamuri PV et al. | Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity. | 2013 | Life Sci. | pmid:22820546 |
Wang P et al. | The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. | 2012 | J. Biol. Chem. | pmid:22829602 |
Matzkin ME et al. | Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake. | 2012 | Gen. Comp. Endocrinol. | pmid:22974512 |
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Weng Y et al. | Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. | 2012 | Mol Pain | pmid:23013719 |
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Kaikkonen S et al. | Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. | 2013 | Mol. Endocrinol. | pmid:23192983 |
Haskew-Layton RE et al. | 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ. | 2013 | J. Neurochem. | pmid:23199167 |
Nakamura M et al. | Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. | 2013 | Biomed. Pharmacother. | pmid:23206752 |
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Sykes L et al. | Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes. | 2012 | PLoS ONE | pmid:23226366 |
Doyle MC et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 inhibits IL-13 production in T cells via an NF-κB-dependent mechanism. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23333326 |
Zerani M et al. | Evidence for a luteotropic role of peroxisome proliferator-activated receptor gamma: expression and in vitro effects on enzymatic and hormonal activities in corpora lutea of pseudopregnant rabbits. | 2013 | Biol. Reprod. | pmid:23365414 |
Xu F et al. | Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. | 2013 | PLoS ONE | pmid:23372817 |
Sykes L et al. | The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour. | 2013 | Immunology | pmid:23374103 |
Nozaki Y et al. | PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. | 2013 | Med Mol Morphol | pmid:23397546 |
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