15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Davies GF et al. | Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism. | 2001 | Biochem. Pharmacol. | pmid:11597575 |
Kim EH and Surh YJ | The role of 15-deoxy-delta(12,14)-prostaglandin J(2), an endogenous ligand of peroxisome proliferator-activated receptor gamma, in tumor angiogenesis. | 2008 | Biochem. Pharmacol. | pmid:18771658 |
Cocca C et al. | 15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest. | 2009 | Biochem. Pharmacol. | pmid:19576185 |
Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
Lin Q et al. | Ligand selectivity of the peroxisome proliferator-activated receptor alpha. | 1999 | Biochemistry | pmid:9890897 |
Paumi CM et al. | Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). | 2004 | Biochemistry | pmid:14979731 |
Li H et al. | Serum amyloid A activates peroxisome proliferator-activated receptor γ through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes. | 2010 | Biochemistry | pmid:20853849 |
Shibata T et al. | An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome. | 2003 | Biochemistry | pmid:14636064 |
Paumi CM et al. | Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. | 2003 | Biochemistry | pmid:12731885 |
Prage EB et al. | Observation of two modes of inhibition of human microsomal prostaglandin E synthase 1 by the cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2). | 2012 | Biochemistry | pmid:22356188 |
Penas F et al. | Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice. | 2015 | Biochim. Biophys. Acta | pmid:25557389 |
Asano T et al. | Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) expresses in rat mesangial cells and PPARgamma agonists modulate its differentiation. | 2000 | Biochim. Biophys. Acta | pmid:10838168 |
Gates D et al. | Apo J/clusterin expression and secretion: evidence for 15-deoxy-Δ(12,14)-PGJ(2)-dependent mechanism. | 2012 | Biochim. Biophys. Acta | pmid:22138303 |
Buechler C et al. | Adipophilin is a sensitive marker for lipid loading in human blood monocytes. | 2001 | Biochim. Biophys. Acta | pmid:11420178 |
O'Flaherty JT et al. | 5-Oxo-ETE analogs and the proliferation of cancer cells. | 2005 | Biochim. Biophys. Acta | pmid:16154383 |
Yu Y et al. | Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. | 2002 | Biochim. Biophys. Acta | pmid:12020636 |
Lian TW et al. | Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. | 2008 | Biochim. Biophys. Acta | pmid:18662803 |
Numazawa S et al. | Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. | 2012 | Biol. Pharm. Bull. | pmid:22382320 |
Zerani M et al. | Evidence for a luteotropic role of peroxisome proliferator-activated receptor gamma: expression and in vitro effects on enzymatic and hormonal activities in corpora lutea of pseudopregnant rabbits. | 2013 | Biol. Reprod. | pmid:23365414 |
Desmarais JA et al. | The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). | 2007 | Biol. Reprod. | pmid:17615406 |
Ackerman WE et al. | Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. | 2005 | Biol. Reprod. | pmid:15843495 |
Huang L et al. | 15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model. | 2015 | Biomed Res Int | pmid:26844229 |
Maekawa N et al. | High-performance affinity purification for identification of 15-deoxy-Δ 12,14 -PGJ₂ interacting factors using magnetic nanobeads. | 2011 | Biomed. Chromatogr. | pmid:21374648 |
Nakamura M et al. | Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. | 2013 | Biomed. Pharmacother. | pmid:23206752 |
Kohno S et al. | Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma. | 2006 | Biomed. Pharmacother. | pmid:16337105 |
Xue J et al. | Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. | 2010 | Biomed. Pharmacother. | pmid:19880272 |
Pedersen PJ et al. | Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20591667 |
Usui S et al. | Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15745794 |
Tsutsui C et al. | Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19559609 |
Pande V and Ramos MJ | Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16006125 |
Moulin D et al. | Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. | 2006 | Biorheology | pmid:16912428 |
Piva R et al. | 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. | 2005 | Blood | pmid:15498850 |
Hasegawa H et al. | A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. | 2007 | Blood | pmid:17551094 |
Appel S et al. | PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. | 2005 | Blood | pmid:16105976 |
Zhang X et al. | Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells. | 2004 | Blood | pmid:15265789 |
Akbiyik F et al. | Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. | 2004 | Blood | pmid:15130939 |
Chaffer CL et al. | PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. | 2006 | BMC Cancer | pmid:16519808 |
Nakahata Y et al. | The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. | 2006 | BMC Mol. Biol. | pmid:16483373 |
Garg TK and Chang JY | Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. | 2003 | BMC Ophthalmol | pmid:12659653 |
Garg TK and Chang JY | 15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. | 2004 | BMC Pharmacol. | pmid:15149553 |
Lin TH et al. | PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. | 2007 | Bone | pmid:17669705 |
Hounoki H et al. | Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. | 2008 | Bone | pmid:18242157 |
Chearwae W and Bright JJ | PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells. | 2008 | Br. J. Cancer | pmid:19018263 |
Siavash H et al. | Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. | 2004 | Br. J. Cancer | pmid:15316561 |
Nikitakis NG et al. | 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells. | 2002 | Br. J. Cancer | pmid:12454768 |
Downie MM et al. | Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 | Br. J. Dermatol. | pmid:15491415 |
Pacienza N et al. | 15-deoxy-Delta(12,14)-PGJ(2) induces cell cycle arrest and apoptosis of haematopoietic progenitors. | 2010 | Br. J. Haematol. | pmid:19764987 |
Ward JE et al. | PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. | 2004 | Br. J. Pharmacol. | pmid:14718259 |
Bishop-Bailey D et al. | Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line. | 2000 | Br. J. Pharmacol. | pmid:11030710 |
Du H et al. | Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. | 2011 | Br. J. Pharmacol. | pmid:21501147 |
Bardelli C et al. | Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands. | 2012 | Br. J. Pharmacol. | pmid:21745193 |
Wasinger C et al. | Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells. | 2014 | Br. J. Pharmacol. | pmid:25091578 |
Alves C et al. | Effects of 15d-PGJâ‚‚-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. | 2011 | Br. J. Pharmacol. | pmid:20883476 |
Wright DH et al. | Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. | 1998 | Br. J. Pharmacol. | pmid:9579725 |
Davidson J et al. | Eicosapentaenoic acid suppression of systemic inflammatory responses and inverse up-regulation of 15-deoxyΔ(12,14) prostaglandin J2 production. | 2013 | Br. J. Pharmacol. | pmid:23586396 |
Paukkeri EL et al. | PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. | 2007 | Br. J. Pharmacol. | pmid:17891158 |
Chen A and Zheng S | Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. | 2008 | Br. J. Pharmacol. | pmid:17965732 |
Cuzzocrea S et al. | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. | 2003 | Br. J. Pharmacol. | pmid:12970094 |
Cuzzocrea S et al. | The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. | 2003 | Br. J. Pharmacol. | pmid:12598422 |
Hao GH et al. | Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts. | 2008 | Br. J. Pharmacol. | pmid:18278065 |
Kane CJ et al. | Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists. | 2011 | Brain Behav. Immun. | pmid:21376806 |
Kim EJ et al. | Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2. | 2002 | Brain Res. | pmid:12031542 |
Koppal T et al. | Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. | 2000 | Brain Res. | pmid:10837804 |
Ou Z et al. | Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2--mediated protection of brain after experimental cerebral ischemia in rat. | 2006 | Brain Res. | pmid:16725118 |
Drew PD et al. | Hormone regulation of microglial cell activation: relevance to multiple sclerosis. | 2005 | Brain Res. Brain Res. Rev. | pmid:15850670 |
Liu H et al. | PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. | 2003 | Breast Cancer Res. Treat. | pmid:12779083 |
Yee LD et al. | The antiproliferative effects of PPARgamma ligands in normal human mammary epithelial cells. | 2003 | Breast Cancer Res. Treat. | pmid:12725418 |
Kamagata C et al. | 15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. | 2007 | Breast Cancer Res. Treat. | pmid:17028981 |
Maurin AC et al. | Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. | 2005 | Calcif. Tissue Int. | pmid:15868283 |
Liu J et al. | Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15838654 |
Nagata D et al. | Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. | 2008 | Cancer Detect. Prev. | pmid:18789607 |
Sabichi AL et al. | Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15533896 |
Subbarayan V et al. | Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15533897 |
Fu YG et al. | Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1. | 2006 | Cancer Lett. | pmid:16412567 |
Qiao L et al. | Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. | 2008 | Cancer Lett. | pmid:18477501 |
Tan BS et al. | 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). | 2013 | Cancer Lett. | pmid:23612072 |
Núñez NP et al. | PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. | 2006 | Cancer Lett. | pmid:15979236 |
Siavash H et al. | Targeting of epidermal growth factor receptor by cyclopentenone prostaglandin 15-Deoxy-Delta12,14-prostaglandin J2 in human oral squamous carcinoma cells. | 2004 | Cancer Lett. | pmid:15194221 |
James SY et al. | Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. | 2003 | Cancer Res. | pmid:12839938 |
Rubin GL et al. | Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy. | 2000 | Cancer Res. | pmid:10749129 |
Houston KD et al. | Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. | 2003 | Cancer Res. | pmid:12649180 |
Vanaja DK et al. | Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells. | 2000 | Cancer Res. | pmid:10987274 |
Kim HJ et al. | 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. | 2007 | Cancer Res. | pmid:17363578 |
Badawi AF et al. | Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. | 2004 | Cancer Res. | pmid:14871855 |
Grau R et al. | Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. | 2004 | Cancer Res. | pmid:15289320 |
Chinery R et al. | Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. | 1999 | Cancer Res. | pmid:10364000 |
Zimmer M et al. | The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. | 2010 | Cancer Res. | pmid:20354189 |
Park EY et al. | Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. | 2004 | Cancer Res. | pmid:15150131 |
Millán O et al. | Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. | 2006 | Carcinogenesis | pmid:16113051 |
Pavan L et al. | Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPARgamma in cell invasion process. | 2003 | Carcinogenesis | pmid:12807721 |
Kim DH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. | 2009 | Carcinogenesis | pmid:19136476 |
Kim EH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. | 2008 | Carcinogenesis | pmid:18192694 |
Viñals M et al. | Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages. | 2005 | Cardiovasc. Res. | pmid:15769457 |
Chintalgattu V et al. | PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts. | 2007 | Cardiovasc. Res. | pmid:17320065 |
Ramji DP | Growth hormone-releasing peptides, CD36, and stimulation of cholesterol efflux: cyclooxygenase-2 is the link. | 2009 | Cardiovasc. Res. | pmid:19520704 |
Tomita H et al. | Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. | 2005 | Cardiovasc. Res. | pmid:15949477 |
Bujold K et al. | CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. | 2009 | Cardiovasc. Res. | pmid:19377069 |
Chatterjee PK et al. | The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. | 2004 | Cardiovasc. Res. | pmid:14962493 |
Forman BM et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | 1995 | Cell | pmid:8521497 |
Kliewer SA et al. | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | 1995 | Cell | pmid:8521498 |