15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Marx N et al. | PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073956 |
Xin X et al. | Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. | 1999 | J. Biol. Chem. | pmid:10085162 |
Petrova TV et al. | Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200320 |
Goetze S et al. | PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10226869 |
Torii SI et al. | Thiazolidinedione induces the adipose differentiation of fibroblast-like cells resident within bovine skeletal muscle. | 1998 | Cell Biol. Int. | pmid:10328850 |
Bishop-Bailey D and Hla T | Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. | 1999 | J. Biol. Chem. | pmid:10358055 |
Chinery R et al. | Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. | 1999 | Cancer Res. | pmid:10364000 |
Gilroy DW et al. | Inducible cyclooxygenase may have anti-inflammatory properties. | 1999 | Nat. Med. | pmid:10371510 |
Kwon G et al. | Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and inos expression. | 1999 | J. Biol. Chem. | pmid:10373483 |