15-deoxy-delta-12,14-PGJ2

15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-deoxy-delta-12,14-PGJ2?

15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperalgesia D006930 42 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Neoplasms D008175 171 associated lipids
Myocardial Infarction D009203 21 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 | Total 30

PubChem Associated disorders and diseases

What pathways are associated with 15-deoxy-delta-12,14-PGJ2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 15-deoxy-delta-12,14-PGJ2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 15-deoxy-delta-12,14-PGJ2

Download all related citations
Per page 10 20 50 100 | Total 940
Authors Title Published Journal PubMed Link
Suwaki N et al. Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. 2007 Placenta pmid:16753211
Gayarre J et al. Modification of proteins by cyclopentenone prostaglandins is differentially modulated by GSH in vitro. 2007 Ann. N. Y. Acad. Sci. pmid:17405918
Hagens WI et al. Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. 2007 Pharm. Res. pmid:17245650
Yang C et al. Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. 2007 Am. J. Pathol. pmid:17255338
Li CF et al. [Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. 2007 Beijing Da Xue Xue Bao pmid:17304332
Kim HJ et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. 2007 Cancer Res. pmid:17363578
Fionda C et al. 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. 2007 J. Immunol. pmid:17371958
Hasegawa H et al. A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. 2007 Blood pmid:17551094
Monroy MA et al. THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. 2007 Shock pmid:17510607
Zingarelli B et al. Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. 2007 Shock pmid:17589386
Vunta H et al. The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. 2007 J. Biol. Chem. pmid:17439952
Ponferrada A et al. The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. 2007 Gastroenterology pmid:17484875
Cerbone A et al. 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. 2007 Free Radic. Biol. Med. pmid:17462534
Hwang J et al. 15-deoxy-Delta12,14-prostaglandin J2-induced down-regulation of endothelial nitric oxide synthase in association with HSP70 induction. 2007 Biochem. Biophys. Res. Commun. pmid:17418102
Arnold R et al. Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. 2007 Immunology pmid:17425601
Li SJ et al. [Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof]. 2007 Zhonghua Yi Xue Za Zhi pmid:17425848
Zhao X et al. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. 2007 Ann. Neurol. pmid:17457822
Berry A et al. IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. 2007 Eur. J. Immunol. pmid:17458857
Lim HJ et al. 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells. 2007 Toxicol. Appl. Pharmacol. pmid:17631927
Desmarais JA et al. The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). 2007 Biol. Reprod. pmid:17615406
Kaplan J et al. Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. 2007 Shock pmid:17621259
Paukkeri EL et al. PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. 2007 Br. J. Pharmacol. pmid:17891158
Ou YC et al. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. 2007 Eur. J. Pharmacol. pmid:17341418
Schlezinger JJ et al. An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells. 2007 Toxicol. Sci. pmid:17400580
Rajakariar R et al. Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18077391
Kim KY et al. Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. 2007 Mol. Pharmacol. pmid:17535976
Yoon EK et al. ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. 2007 J. Korean Med. Sci. pmid:18162716
Cao LQ et al. [15-deoxy-Delta(12,14)-prostaglandin J(2) induces anoikis of hepatocellular carcinoma cells: an in vitro experiment]. 2007 Zhonghua Yi Xue Za Zhi pmid:18261336
Rollins MD et al. Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. 2006 Sep-Oct J. Gastrointest. Surg. pmid:16966031
Lappas M et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. 2006 Nov-Dec Placenta pmid:16434095
Chaffer CL et al. PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. 2006 BMC Cancer pmid:16519808
Rockwell CE et al. Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. 2006 Mol. Pharmacol. pmid:16611855
Merwald H et al. Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. 2006 Cell Stress Chaperones pmid:16572732
Arnold R and König W Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. 2006 Virology pmid:16330064
Lin TN et al. 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16385084
Landar A et al. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16387790
Na HK and Surh YJ Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection. 2006 Mol. Carcinog. pmid:16673384
Hickson-Bick DL et al. The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. 2006 Shock pmid:16680021
Sun K et al. PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. 2006 Acta Pharmacol. Sin. pmid:16723090
Ou Z et al. Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2--mediated protection of brain after experimental cerebral ischemia in rat. 2006 Brain Res. pmid:16725118
Yasugi E et al. Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells. 2006 Dev. Growth Differ. pmid:16573735
Cuzzocrea S Peroxisome proliferator-activated receptors and acute lung injury. 2006 Curr Opin Pharmacol pmid:16580256
Suzuki T et al. Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions. 2006 Endocr. Relat. Cancer pmid:16601291
Zhang YF et al. Peroxisome proliferator-activated receptor-gamma is expressed by rat peritoneal mesothelial cells: its potential role in peritoneal cavity local defense. 2006 Am. J. Nephrol. pmid:17183189
Núñez NP et al. PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. 2006 Cancer Lett. pmid:15979236
Raikwar HP et al. PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. 2006 J. Neuroimmunol. pmid:16844232
Coyle AT and Kinsella BT Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. 2006 Biochem. Pharmacol. pmid:16499875
Masuda H et al. 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. 2006 Urology pmid:16461118
Nakahata Y et al. The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. 2006 BMC Mol. Biol. pmid:16483373
Yeh CH et al. Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. 2006 Shock pmid:16912651