15-deoxy-delta-12,14-PGJ2

15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.

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Introduction

To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-deoxy-delta-12,14-PGJ2?

15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Brain Ischemia D002545 89 associated lipids
Insulin Resistance D007333 99 associated lipids
Inflammation D007249 119 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 30

PubChem Associated disorders and diseases

What pathways are associated with 15-deoxy-delta-12,14-PGJ2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

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What functions are associated with 15-deoxy-delta-12,14-PGJ2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-deoxy-delta-12,14-PGJ2?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 15-deoxy-delta-12,14-PGJ2

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Authors Title Published Journal PubMed Link
Sawai H et al. Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. 2006 Mol. Cancer Res. pmid:16547153
Huang H et al. Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. 2004 Mol. Cancer Res. pmid:15498928
Kim YI et al. Effects of 15-deoxy-∆¹²,¹⁴-prostaglandin J₂ on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. 2011 Mol. Biol. Rep. pmid:20174873
Weng Y et al. Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. 2012 Mol Pain pmid:23013719
Cruz-Orengo L et al. Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. 2008 Mol Pain pmid:18671867
Fain JN et al. Regulation of leptin release by troglitazone in human adipose tissue. 2000 Metab. Clin. Exp. pmid:11092516
Sinha D et al. 15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene. 1999 Metab. Clin. Exp. pmid:10381155
Rodrigues WF et al. 15d-PGJ(2) modulates acute immune responses to Trypanosoma cruzi infection. 2010 Mem. Inst. Oswaldo Cruz pmid:20428671
Sykes L et al. Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. 2012 Mediators Inflamm. pmid:22690041
Carregaro V et al. Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25-FOXP3+ Cells. 2016 Mediators Inflamm. pmid:27872515
Nozaki Y et al. PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. 2013 Med Mol Morphol pmid:23397546
Kim HJ et al. ROSics: chemistry and proteomics of cysteine modifications in redox biology. 2015 Mar-Apr Mass Spectrom Rev pmid:24916017
Date M et al. 15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells. 2003 Liver Int. pmid:14986820
Gressner OA et al. Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. 2009 Liver Int. pmid:19018984
Kang MA et al. Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. 2007 Life Sci. pmid:17161435
Wung BS et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. 2006 Life Sci. pmid:16413037
Shirahase H et al. Inhibitory effects of PGD2, PGJ2 and 15-deoxy-delta12,14-PGJ2 on iNOS induction in rat mesenteric artery. 2000 Life Sci. pmid:10834301
Liu JD et al. Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. 2004 Life Sci. pmid:14998722
Stebulis JA et al. Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells. 2008 Life Sci. pmid:18840450
Clemente-Napimoga JT et al. 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. 2012 Life Sci. pmid:22564409
Jung WK et al. The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. 2009 Life Sci. pmid:19409914
Kattamuri PV et al. Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity. 2013 Life Sci. pmid:22820546
Hayden RE et al. Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. 2009 Leukemia pmid:18923439
Zang C et al. Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. 2004 Leuk. Res. pmid:15109539
Okano H et al. 15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. 2003 Lab. Invest. pmid:14563954
Chung YW et al. [Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells]. 2003 Korean J Gastroenterol pmid:14532729
Rovin BH et al. 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death. 2002 Kidney Int. pmid:11918736
Sawano H et al. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. 2002 Kidney Int. pmid:12028436
Stahlschmidt J et al. Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. 2005 Kidney Int. pmid:16105033
Zhang X et al. Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells. 2004 Kidney Int. pmid:14871400
Ueta M et al. PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. 2004 Kidney Int. pmid:14871416
Chana RS et al. Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. 2004 Kidney Int. pmid:15149321
Calabrò P et al. Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. 2005 Nov-Dec J. Vasc. Res. pmid:16155367
Hong JT et al. Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. 2002 J. Toxicol. Environ. Health Part A pmid:11936221
Moraes LA et al. Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. 2010 J. Thromb. Haemost. pmid:20040043
O'Brien JJ et al. 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. 2009 J. Thromb. Haemost. pmid:18983509
Byrns MC et al. Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. 2010 J. Steroid Biochem. Mol. Biol. pmid:20036328
Davidson J et al. 7beta-hydroxy-epiandrosterone modulation of 15-deoxy-delta12,14-prostaglandin J2, prostaglandin D2 and prostaglandin E2 production from human mononuclear cells. 2008 J. Steroid Biochem. Mol. Biol. pmid:18996481
Andrews WJ et al. Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. 2005 J. Steroid Biochem. Mol. Biol. pmid:15862961
Li X et al. Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. 2005 J. Rheumatol. pmid:15868626
Viergutz T et al. Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor gamma protein in bovine large lutein cells. 2000 J. Reprod. Fertil. pmid:10793637
Cha B et al. 15-deoxy-D12,14-prostaglandin J2 suppresses RANTES expression by inhibiting NADPH oxidase activation in Helicobacter pylori-infected gastric epithelial cells. 2011 J. Physiol. Pharmacol. pmid:21673364
Korolczuk A et al. The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity. 2014 J. Physiol. Pharmacol. pmid:25554991
Abdo H et al. The omega-6 fatty acid derivative 15-deoxy-Δ¹²,¹⁴-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress. 2012 J. Physiol. (Lond.) pmid:22473776
Bach-Ngohou K et al. Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. 2010 J. Physiol. (Lond.) pmid:20478974
Hatanaka M et al. 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. 2010 J. Pharmacol. Sci. pmid:20424389
Azuma Y et al. Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1. 2004 J. Pharmacol. Sci. pmid:15037811
Takata K et al. Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. 2003 J. Pharmacol. Sci. pmid:12719662
Davies GF et al. Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes. 2002 J. Pharmacol. Exp. Ther. pmid:11752099
Yamazaki R et al. Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells. 2002 J. Pharmacol. Exp. Ther. pmid:12065695
Almishri W et al. Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. 2005 J. Pharmacol. Exp. Ther. pmid:15590767
Laurora S et al. Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. 2003 J. Pharmacol. Exp. Ther. pmid:12649303
Napimoga MH et al. 15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor. 2008 J. Pharmacol. Exp. Ther. pmid:17928570
Kim EJ et al. Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. 2003 J. Pharmacol. Exp. Ther. pmid:12966153
Hata AN et al. Expression and molecular pharmacology of the mouse CRTH2 receptor. 2003 J. Pharmacol. Exp. Ther. pmid:12721327
Shimomura K et al. Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. 2004 J. Pharmacol. Exp. Ther. pmid:15201343
Raman P et al. 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. 2012 J. Pharmacol. Exp. Ther. pmid:22700433
Mirza RE et al. Macrophage PPARγ and impaired wound healing in type 2 diabetes. 2015 J. Pathol. pmid:25875529
Kim NJ et al. Concise and enantioselective total synthesis of 15-deoxy-Δ-(12,14)-prostaglandin J(2). 2010 J. Org. Chem. pmid:20929274
Chattopadhyay N et al. Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis. 2000 J. Neurosci. Res. pmid:10861801
Storer PD et al. Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. 2005 J. Neurosci. Res. pmid:15723383
Smith SA et al. Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability. 2003 J. Neurosci. Res. pmid:12774315
Kim SE et al. 15-deoxy-Δ¹²,¹⁴ -prostaglandin J₂ inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-γ and heme oxygenase-1 in rat hippocampal slices. 2012 J. Neurosci. Res. pmid:22487967
Heneka MT et al. Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. 2000 J. Neurosci. pmid:10995830
Mouihate A et al. A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. 2004 J. Neurosci. pmid:14960602
De Nuccio C et al. Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves. 2011 J. Neuropathol. Exp. Neurol. pmid:21937914
Bernardo A et al. Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. 2009 J. Neuropathol. Exp. Neurol. pmid:19535992
Storer PD et al. Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. 2005 J. Neuroimmunol. pmid:15748950
Zhang F et al. Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells. 2010 J. Neuroimmunol. pmid:19942298
Drew PD and Chavis JA The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. 2001 J. Neuroimmunol. pmid:11282151
Diab A et al. Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. 2004 J. Neuroimmunol. pmid:14975592
Garg TK and Chang JY Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. 2006 J. Neuroimmunol. pmid:16225932
Raikwar HP et al. PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. 2006 J. Neuroimmunol. pmid:16844232
Zhao ML et al. 15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. 2004 J. Neuroimmunol. pmid:15265671
Haskew-Layton RE et al. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ. 2013 J. Neurochem. pmid:23199167
Hosoi T et al. Possible involvement of 15-deoxy-Δ(12,14) -prostaglandin J2 in the development of leptin resistance. 2015 J. Neurochem. pmid:25662180
Liang X et al. Prostaglandin D2 mediates neuronal protection via the DP1 receptor. 2005 J. Neurochem. pmid:15659218
Ajmone-Cat MA et al. Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E2 synthesis. 2003 J. Neurochem. pmid:14622099
Phulwani NK et al. 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. 2006 J. Neurochem. pmid:17074064
Bernardo A et al. 15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms. 2003 J. Neurochem. pmid:14535956
Kielian T et al. S. aureus-dependent microglial activation is selectively attenuated by the cyclopentenone prostaglandin 15-deoxy-Delta12,14- prostaglandin J2 (15d-PGJ2). 2004 J. Neurochem. pmid:15312171
Saito Y et al. Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. 2007 J. Neurochem. pmid:17697048
Heiss EH et al. Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata. 2014 J. Nat. Prod. pmid:24476568
Abraki SB et al. Simultaneous inhibition of COX-2 and activation of PPAR-γ resulted in the same level and pattern of neuroprotection as they were targeted separately. 2013 J. Mol. Neurosci. pmid:23132402
Vishwakarma P et al. 15d-Prostaglandin J2 induced reactive oxygen species-mediated apoptosis during experimental visceral leishmaniasis. 2016 J. Mol. Med. pmid:26830627
Waku T et al. Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids. 2009 J. Mol. Biol. pmid:18977231
Kim HY et al. Upregulation of lipopolysaccharide-induced interleukin-10 by prostaglandin A1 in mouse peritoneal macrophages. 2008 J. Microbiol. Biotechnol. pmid:18600064
Feng J et al. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. 2000 J. Lipid Res. pmid:10787429
Hardy KD et al. Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. 2011 J. Lipid Res. pmid:20944061
Springstead JR et al. Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function. 2012 J. Lipid Res. pmid:22550136
Martínez B et al. The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. 2005 J. Lipid Res. pmid:15654126
Clay CE et al. 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. 2002 J. Lipid Res. pmid:12401880
Ramer R et al. Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. 2013 J. Lipid Res. pmid:23943857
Schröder O et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. 2006 J. Lipid Res. pmid:16495511
Guyton K et al. Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation. 2001 J. Leukoc. Biol. pmid:11310850
Alba G et al. Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. 2008 J. Leukoc. Biol. pmid:18515325
Tautenhahn A et al. Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis. 2003 J. Leukoc. Biol. pmid:12714582
De Oliveira C et al. Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. 2005 J. Lab. Clin. Med. pmid:15871306
Lee JH et al. 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. 2007 J. Korean Med. Sci. pmid:17982241
Yoon EK et al. ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. 2007 J. Korean Med. Sci. pmid:18162716