15-deoxy-delta-12,14-PGJ2

15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-deoxy-delta-12,14-PGJ2?

15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2

MeSH term MeSH ID Detail
Pancreatic Neoplasms D010190 77 associated lipids
Parkinson Disease D010300 53 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Thrombosis D013927 49 associated lipids
Weight Loss D015431 56 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Per page 10 20 50 | Total 30

PubChem Associated disorders and diseases

What pathways are associated with 15-deoxy-delta-12,14-PGJ2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 15-deoxy-delta-12,14-PGJ2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 15-deoxy-delta-12,14-PGJ2

Download all related citations
Per page 10 20 50 100 | Total 940
Authors Title Published Journal PubMed Link
Forman BM et al. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. 1995 Cell pmid:8521497
Kliewer SA et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. 1995 Cell pmid:8521498
Makino N et al. Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia. 2006 Cell Biochem. Biophys. pmid:16456235
Torii SI et al. Thiazolidinedione induces the adipose differentiation of fibroblast-like cells resident within bovine skeletal muscle. 1998 Cell Biol. Int. pmid:10328850
Wang JJ and Mak OT Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGDâ‚‚ metabolite, 15d-PGJâ‚‚. 2011 Cell Biol. Int. pmid:21999315
Zhu F et al. Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. 2010 Cell Death Differ. pmid:20150912
Austin S et al. Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells. 1998 Cell Growth Differ. pmid:9543393
Butler R et al. Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2. 2000 Cell Growth Differ. pmid:10672903
Campo PA et al. Translational regulation of cyclin D1 by 15-deoxy-delta(12,14)-prostaglandin J(2). 2002 Cell Growth Differ. pmid:12354750
Merwald H et al. Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. 2006 Cell Stress Chaperones pmid:16572732
Bancos S et al. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. 2010 Cell. Immunol. pmid:20064636
Farnesi-de-Assunção TS et al. PPAR-γ agonists, mainly 15d-PGJ(2), reduce eosinophil recruitment following allergen challenge. 2012 Cell. Immunol. pmid:22192475
Muñoz U et al. On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. 2008 Cell. Mol. Life Sci. pmid:18818877
Olmos G et al. 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. 2009 Cell. Mol. Life Sci. pmid:19458911
Xu X et al. Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism. 2015 Cell. Physiol. Biochem. pmid:26279448
Meng Y et al. Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-γ ligand 15d-PGJ₂ in macrophages. 2015 Cell. Physiol. Biochem. pmid:25591955
Niemoeller OM et al. Ciglitazone and 15d-PGJ2 induced suicidal erythrocyte death. 2008 Cell. Physiol. Biochem. pmid:18769050
Ye F et al. Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. 2006 Cell. Physiol. Biochem. pmid:16914899
Yucel-Lindberg T et al. Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. 2006 Cell. Signal. pmid:16766159
Nosjean O and Boutin JA Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part? 2002 Cell. Signal. pmid:11955950
Olmos G et al. Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. 2007 Cell. Signal. pmid:17658243
Patel KM et al. Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). 2005 Cell. Signal. pmid:15993751
Mo C et al. PPARgamma regulates LIF-induced growth and self-renewal of mouse ES cells through Tyk2-Stat3 pathway. 2010 Cell. Signal. pmid:19922793
Tanaka H et al. Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives. 2006 Chem Asian J pmid:17441107
Chen S et al. 15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) promotes apoptosis of HBx-positive liver cells. 2014 Chem. Biol. Interact. pmid:24582817
Song NY et al. Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells. 2011 Chem. Res. Toxicol. pmid:21728338
Ishii T and Uchida K Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. 2004 Chem. Res. Toxicol. pmid:15487891
Uchida K and Shibata T 15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses. 2008 Chem. Res. Toxicol. pmid:18052108
Brunoldi EM et al. Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. 2007 Chem. Res. Toxicol. pmid:17854155
Han S et al. Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression. 2004 Chest pmid:15136464
Tang Q et al. Effect of 15-Deoxy-Δ12,14-prostaglandin J2Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model. 2017 Chin. Med. J. pmid:28139520
Taba Y et al. Fluid shear stress induces lipocalin-type prostaglandin D(2) synthase expression in vascular endothelial cells. 2000 Circ. Res. pmid:10807869
Charles RL et al. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. 2011 Circ. Res. pmid:21164107
Marx N et al. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. 1998 Circ. Res. pmid:9831704
Yano M et al. Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. 2007 Circ. Res. pmid:17463321
Verrier E et al. PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase. 2004 Circ. Res. pmid:15117825
Tobiasova Z et al. Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. 2011 Circulation pmid:21690493
Takeda K et al. Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells. 2000 Circulation pmid:11023940
Yamamoto K et al. Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes. 2001 Circulation pmid:11581147
Thomas RK et al. Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. 2005 Clin. Cancer Res. pmid:16299251
Shin SW et al. 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. 2009 Clin. Cancer Res. pmid:19690198
Koyama M et al. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. 2010 Clin. Cancer Res. pmid:20371690
Thévenon C et al. Gas chromatographic-mass spectrometric measurement of 15-deoxy-delta(12,14)-prostaglandin J(2), the peroxisome proliferator-activated receptor gamma ligand, in urine. 2001 Clin. Chem. pmid:11274037
Kim SH et al. Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma. 2010 Clin. Exp. Immunol. pmid:20345975
Zhang J et al. Peroxisome proliferator-activated receptor-gamma agonists attenuate angiotensin II-induced collagen type I expression in adventitial fibroblasts. 2008 Clin. Exp. Pharmacol. Physiol. pmid:18047631
Inoue K et al. Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. 2005 Clin. Exp. Pharmacol. Physiol. pmid:15743408
Ray DM et al. Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. 2004 Clin. Immunol. pmid:15451478
Scher JU and Pillinger MH 15d-PGJ2: the anti-inflammatory prostaglandin? 2005 Clin. Immunol. pmid:15639643
Padilla J et al. Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. 2002 Clin. Immunol. pmid:11987982
Oku H and Umino T Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major. 2008 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:18691667