15-deoxy-delta-12,14-PGJ2

15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-deoxy-delta-12,14-PGJ2?

15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2

MeSH term MeSH ID Detail
Pancreatic Neoplasms D010190 77 associated lipids
Parkinson Disease D010300 53 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Thrombosis D013927 49 associated lipids
Weight Loss D015431 56 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Per page 10 20 50 | Total 30

PubChem Associated disorders and diseases

What pathways are associated with 15-deoxy-delta-12,14-PGJ2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 15-deoxy-delta-12,14-PGJ2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 15-deoxy-delta-12,14-PGJ2

Download all related citations
Per page 10 20 50 100 | Total 940
Authors Title Published Journal PubMed Link
Zhao X et al. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. 2007 Ann. Neurol. pmid:17457822
Liu JJ et al. Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. 2005 Ann. Oncol. pmid:15642706
Chen SY et al. 15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. 2002 Anticancer Drugs pmid:12187333
Eucker J et al. Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. 2004 Anticancer Drugs pmid:15514564
Fulzele SV et al. 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. 2007 Anticancer Drugs pmid:17159504
Eucker J et al. Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. 2006 Anticancer Drugs pmid:16926626
Dionne S et al. PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. 2010 Anticancer Res. pmid:20150631
Kumar AP et al. Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. 2014 Antioxid. Redox Signal. pmid:23964924
Caito S et al. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. 2008 Antioxid. Redox Signal. pmid:17970647
Gong P et al. Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. 2002 Antioxid. Redox Signal. pmid:12006176
Jozkowicz A et al. 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. 2008 Antioxid. Redox Signal. pmid:18665800
Han H et al. 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. 2007 Apoptosis pmid:17786557
Syeda PK et al. Generation of monoclonal antibody for 15-deoxy-Δ¹²,¹⁴-prostaglandin J₂ and development of enzyme-linked immunosorbent assay for its quantification in culture medium of adipocytes. 2012 Appl. Biochem. Biotechnol. pmid:22391692
Sánchez-Gómez FJ et al. Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. 2007 Arch. Biochem. Biophys. pmid:17169324
Mueller C et al. Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. 2003 Arch. Biochem. Biophys. pmid:14522590
Herbertsson H et al. The 650-kDa 12(S)-hydroxyeicosatetraenoic acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit. 1999 Arch. Biochem. Biophys. pmid:10375396
Zhang GY et al. Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro. 2009 Arch. Dermatol. Res. pmid:19466435
Kang HY et al. Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. 2006 Arch. Dermatol. Res. pmid:16474974
Lin TN et al. 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16385084
Polikandriotis JA et al. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:16020752
Migita H and Morser J 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15662020
Marx N et al. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10073956
Hofnagel O et al. Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15271788
Abe M et al. GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12615657
Levonen AL et al. Biphasic effects of 15-deoxy-delta(12,14)-prostaglandin J(2) on glutathione induction and apoptosis in human endothelial cells. 2001 Arterioscler. Thromb. Vasc. Biol. pmid:11701476
Cipollone F et al. Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15155382
Calnek DS et al. Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12524224
Ulivi V et al. Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. 2011 Arthritis Res. Ther. pmid:21682897
Bianchi A et al. Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2. 2005 Arthritis Res. Ther. pmid:16277686
Kalajdzic T et al. Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. 2002 Arthritis Rheum. pmid:11840453
Moulin D et al. Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. 2005 Arthritis Rheum. pmid:15751073
Farrajota K et al. Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. 2005 Arthritis Rheum. pmid:15641079
Inoue K et al. Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide. 2005 Arzneimittelforschung pmid:15819389
Inoue K et al. Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. 2004 Arzneimittelforschung pmid:15612612
Muhammad SN et al. 15d-PGJ2 Induces Apoptosis of MCF-7 and MDA-MB-231 Cells via Increased Intracellular Calcium and Activation of Caspases, Independent of ERα and ERβ. 2016 Asian Pac. J. Cancer Prev. pmid:27509924
Yaacob NS et al. Influence of 17β-estradiol on 15-deoxy-δ12,14 prostaglandin J2 -induced apoptosis in MCF-7 and MDA-MB-231 cells. 2013 Asian Pac. J. Cancer Prev. pmid:24377602
Fu Y et al. Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. 2002 Atherosclerosis pmid:11755918
Tachi M et al. Mass spectrometric determination of prostanoids in rat hypothalamic paraventricular nucleus microdialysates. 2014 Auton Neurosci pmid:24447364
Li P et al. [Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. 2015 Beijing Da Xue Xue Bao pmid:26679661
Li CF et al. [Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. 2007 Beijing Da Xue Xue Bao pmid:17304332
Matsuo T et al. 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. 2004 Biochem. Biophys. Res. Commun. pmid:14741709
Józkowicz A et al. Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. 2004 Biochem. Biophys. Res. Commun. pmid:14715242
Vosseler CA et al. Structural requirements of cyclopentenone prostaglandins to induce endothelial cell apoptosis. 2003 Biochem. Biophys. Res. Commun. pmid:12859958
Jang MK et al. Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. 1999 Biochem. Biophys. Res. Commun. pmid:10558912
Satoh H et al. Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. 1999 Biochem. Biophys. Res. Commun. pmid:9920814
Shen ZN et al. Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. 2005 Biochem. Biophys. Res. Commun. pmid:15694358
Keelan JA et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells. 1999 Biochem. Biophys. Res. Commun. pmid:10471366
Inoue K et al. Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists. 2001 Biochem. Biophys. Res. Commun. pmid:11563856
Chiba Y et al. PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells. 2001 Biochem. Biophys. Res. Commun. pmid:11511093
Mishra N et al. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. 2010 Biochem. Biophys. Res. Commun. pmid:20307494