15-deoxy-delta-12,14-PGJ2

15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.

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Introduction

To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-deoxy-delta-12,14-PGJ2?

15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2

MeSH term MeSH ID Detail
Pancreatic Neoplasms D010190 77 associated lipids
Parkinson Disease D010300 53 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Thrombosis D013927 49 associated lipids
Weight Loss D015431 56 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 15-deoxy-delta-12,14-PGJ2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 15-deoxy-delta-12,14-PGJ2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 15-deoxy-delta-12,14-PGJ2

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Per page 10 20 50 100 | Total 940
Authors Title Published Journal PubMed Link
Tsutsui C et al. Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway. 2009 Bioorg. Med. Chem. Lett. pmid:19559609
Kansanen E et al. Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. 2009 Free Radic. Biol. Med. pmid:19573595
Bernardo A et al. Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. 2009 J. Neuropathol. Exp. Neurol. pmid:19535992
Comabella M et al. Plasma levels of 15d-PGJ are not altered in multiple sclerosis. 2009 Eur. J. Neurol. pmid:19538219
Qin HD et al. Upregulation of peroxisome proliferator-activated receptor-gamma and NADPH oxidases are involved in restenosis after balloon injury. 2009 J. Cell. Physiol. pmid:19562688
Li H and Pauza CD Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells. 2009 PLoS ONE pmid:19888466
Khanim FL et al. Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. 2009 PLoS ONE pmid:19997560
Papageorgiou E et al. Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. 2008 Jul-Aug Mol. Med. pmid:18475308
Moon Y et al. Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic deoxynivalenol. 2008 Toxicol. Appl. Pharmacol. pmid:18485432
Copple IM et al. The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. 2008 Hepatology pmid:18785192
Poncin S et al. Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. 2008 Endocrinology pmid:17884933
Caito S et al. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. 2008 Antioxid. Redox Signal. pmid:17970647
Qiao L et al. Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. 2008 Cancer Lett. pmid:18477501
Davidson J et al. 7beta-hydroxy-epiandrosterone modulation of 15-deoxy-delta12,14-prostaglandin J2, prostaglandin D2 and prostaglandin E2 production from human mononuclear cells. 2008 J. Steroid Biochem. Mol. Biol. pmid:18996481
Reyes-Martin P et al. 15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism. 2008 Pharmacol. Res. pmid:18456507
Yamamoto Y et al. Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats. 2008 J. Gastroenterol. Hepatol. pmid:18565023
Panzer U et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells. 2008 Nephrol. Dial. Transplant. pmid:18596134
Su RY et al. 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. 2008 Mol. Cancer Ther. pmid:18852146
Kim HY et al. Upregulation of lipopolysaccharide-induced interleukin-10 by prostaglandin A1 in mouse peritoneal macrophages. 2008 J. Microbiol. Biotechnol. pmid:18600064
Lee SJ et al. 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis via JNK-mediated mitochondrial pathway in osteoblastic cells. 2008 Toxicology pmid:18450357
Nagata D et al. Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. 2008 Cancer Detect. Prev. pmid:18789607
Chearwae W and Bright JJ 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. 2008 J. Clin. Immunol. pmid:18463970
Ryan AJ et al. 15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase. 2008 J. Biol. Chem. pmid:18614529
Ulivi V et al. 15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation. 2008 J. Cell. Physiol. pmid:18615580
Gressner OA et al. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. 2008 J. Hepatol. pmid:18486259
Ghosh AK et al. Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. 2008 Biochem. Biophys. Res. Commun. pmid:18627765
Genovese T et al. Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. 2008 Shock pmid:18628687
Alba G et al. Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. 2008 J. Leukoc. Biol. pmid:18515325
Yoon HJ et al. Regulation of TLR2 expression by prostaglandins in brain glia. 2008 J. Immunol. pmid:18523308
Bissonnette SL et al. An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. 2008 J. Immunol. pmid:18641309
Qiao L et al. Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer. 2008 Mol. Cancer Ther. pmid:18645029
Capobianco E et al. Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. 2008 Mol. Hum. Reprod. pmid:18621767
Niemoeller OM et al. Ciglitazone and 15d-PGJ2 induced suicidal erythrocyte death. 2008 Cell. Physiol. Biochem. pmid:18769050
Kim JW et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2. 2008 Biochem. Pharmacol. pmid:18775681
Chearwae W and Bright JJ PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells. 2008 Br. J. Cancer pmid:19018263
Le Mée S et al. 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. 2008 Steroids pmid:18555503
Lee JH et al. The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. 2008 J. Immunol. pmid:19050284
Dubourdeau M et al. Opposite roles of STAT and PPARgamma in the induction of p21WAF1 expression by IL-13 in human peripheral blood monocytes. 2008 Eur. Cytokine Netw. pmid:19103521
Muñoz U et al. On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. 2008 Cell. Mol. Life Sci. pmid:18818877
Ferreira-Silva V et al. Effects of 15-deoxy-Delta12, 14 prostaglandin J2 and ciglitazone on human cancer cell cycle progression and death: the role of PPARgamma. 2008 Eur. J. Pharmacol. pmid:18054911
Zhang J et al. Peroxisome proliferator-activated receptor-gamma agonists attenuate angiotensin II-induced collagen type I expression in adventitial fibroblasts. 2008 Clin. Exp. Pharmacol. Physiol. pmid:18047631
Uchida K and Shibata T 15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses. 2008 Chem. Res. Toxicol. pmid:18052108
Yu JH et al. SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. 2008 Int. J. Biochem. Cell Biol. pmid:18035585
Lutzow YS et al. 15-Deoxy-Delta12,14-prostaglandin J2 induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells. 2008 J. Dairy Res. pmid:18226310
Kerr BJ et al. The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury. 2008 Glia pmid:18205174
Hounoki H et al. Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. 2008 Bone pmid:18242157
Crabb SJ et al. BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells. 2008 Oncol. Rep. pmid:18288403
Hong HY et al. Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-delta 12,14-prostaglandin J2 in murine macrophages. 2008 FEBS Lett. pmid:18291107
Liu Y et al. Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection. 2008 Vet. Immunol. Immunopathol. pmid:18394717
Kimura H et al. A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions. 2008 Nephrol. Dial. Transplant. pmid:18367541