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Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells. |
2004 |
Blood |
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Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
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Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. |
2004 |
Cancer Res. |
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15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway. |
2004 |
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S. aureus-dependent microglial activation is selectively attenuated by the cyclopentenone prostaglandin 15-deoxy-Delta12,14- prostaglandin J2 (15d-PGJ2). |
2004 |
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PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. |
2004 |
Am. J. Physiol. Endocrinol. Metab. |
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Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. |
2004 |
Br. J. Cancer |
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Protein thiol modification by 15-deoxy-Delta12,14-prostaglandin J2 addition in mesangial cells: role in the inhibition of pro-inflammatory genes. |
2004 |
Mol. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. |
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Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. |
2004 |
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15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. |
2004 |
J. Immunol. |
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Peroxisome proliferator-activated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells. |
2004 |
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2004 |
J. Hepatol. |
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Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. |
2004 |
Biochem. Biophys. Res. Commun. |
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15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. |
2004 |
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Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranes. |
2004 Sep-Oct |
Placenta |
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Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. |
2004 |
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The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. |
2004 |
J. Immunol. |
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2004 |
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Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. |
2004 |
Chem. Res. Toxicol. |
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Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. |
2004 |
Br. J. Dermatol. |
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Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. |
2004 |
Biochem. Soc. Trans. |
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15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. |
2005 |
Blood |
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Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. |
2004 |
Mol. Cancer Res. |
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Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. |
2004 |
Anticancer Drugs |
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Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. |
2004 |
Cancer Epidemiol. Biomarkers Prev. |
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Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. |
2004 |
Cancer Epidemiol. Biomarkers Prev. |
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The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. |
2004 |
Shock |
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A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. |
2004 |
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15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. |
2004 |
Prostaglandins Other Lipid Mediat. |
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Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. |
2005 |
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Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. |
2005 |
J. Pharmacol. Exp. Ther. |
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Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. |
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Am. J. Physiol., Cell Physiol. |
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Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. |
2004 |
Arzneimittelforschung |
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The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. |
2005 |
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The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. |
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15d-PGJ2: the anti-inflammatory prostaglandin? |
2005 |
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Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. |
2005 |
Arthritis Rheum. |
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The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. |
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2005 |
Arterioscler. Thromb. Vasc. Biol. |
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Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. |
2004 |
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Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. |
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Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. |
2005 |
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Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. |
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Biochem. Biophys. Res. Commun. |
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The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. |
2005 |
Psychopharmacology (Berl.) |
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Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. |
2004 |
Redox Rep. |
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A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. |
2004 |
Redox Rep. |
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Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. |
2005 |
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Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. |
2005 |
Diabetologia |
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PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. |
2005 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. |
2005 |
Clin. Exp. Pharmacol. Physiol. |
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Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2. |
2005 |
Bioorg. Med. Chem. Lett. |
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Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. |
2005 |
J. Neuroimmunol. |
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Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. |
2005 |
Am. J. Respir. Crit. Care Med. |
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Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. |
2005 |
Arthritis Rheum. |
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15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. |
2005 |
J. Clin. Endocrinol. Metab. |
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Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma. |
2005 |
Oncol. Rep. |
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Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages. |
2005 |
Cardiovasc. Res. |
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Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. |
2005 |
Heart |
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Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma. |
2005 |
Urology |
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Marshall JC |
Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome? |
2005 |
Intensive Care Med |
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Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide. |
2005 |
Arzneimittelforschung |
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The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. |
2005 |
Biochem. J. |
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Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. |
2005 |
Mol. Pharmacol. |
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Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. |
2005 |
Cancer Chemother. Pharmacol. |
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Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. |
2005 |
Rheumatology (Oxford) |
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Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. |
2005 |
Biol. Reprod. |
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Hormone regulation of microglial cell activation: relevance to multiple sclerosis. |
2005 |
Brain Res. Brain Res. Rev. |
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Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. |
2005 |
J. Steroid Biochem. Mol. Biol. |
pmid:15862961
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Selective activation of PPARgamma in breast, colon, and lung cancer cell lines. |
2005 |
Mol. Cell. Endocrinol. |
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The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock. |
2005 |
Intensive Care Med |
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Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. |
2005 |
Calcif. Tissue Int. |
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Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. |
2005 |
J. Rheumatol. |
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Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. |
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J. Lab. Clin. Med. |
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The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. |
2005 |
FASEB J. |
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Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. |
2005 |
Immunol. Cell Biol. |
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Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke. |
2005 |
Stroke |
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Aspirin modulates LPS-induced nitric oxide release in rat glial cells. |
2005 Jun 10-17 |
Neurosci. Lett. |
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Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. |
2005 |
Thromb. Haemost. |
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15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. |
2005 |
Reprod. Fertil. Dev. |
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Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. |
2005 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. |
2005 |
J. Biol. Chem. |
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Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. |
2005 |
Mol. Endocrinol. |
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Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. |
2005 |
Cardiovasc. Res. |
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PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. |
2006 |
Cancer Lett. |
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15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. |
2005 |
Shock |
pmid:15988322
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Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). |
2005 |
Cell. Signal. |
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Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. |
2005 |
Neuroscience |
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15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. |
2005 |
Exp. Mol. Med. |
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Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins. |
2005 |
Bioorg. Med. Chem. Lett. |
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Eggler AL et al. |
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
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15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. |
2005 |
Int. J. Oncol. |
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Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. |
2005 |
Arterioscler. Thromb. Vasc. Biol. |
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Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. |
2006 |
J. Cereb. Blood Flow Metab. |
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Glycolaldehyde-modified bovine serum albumin downregulates leptin expression in mouse adipocytes via a CD36-mediated pathway. |
2005 |
Ann. N. Y. Acad. Sci. |
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