15-deoxy-delta-12,14-PGJ2

15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.

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Introduction

To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-deoxy-delta-12,14-PGJ2?

15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2

MeSH term MeSH ID Detail
Leukemia, B-Cell D015448 3 associated lipids
Graves Ophthalmopathy D049970 3 associated lipids
Actinobacillus Infections D000189 4 associated lipids
Goiter D006042 4 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Myocardial Infarction D009203 21 associated lipids
Fibrosis D005355 23 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 15-deoxy-delta-12,14-PGJ2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 15-deoxy-delta-12,14-PGJ2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 15-deoxy-delta-12,14-PGJ2

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Per page 10 20 50 100 | Total 940
Authors Title Published Journal PubMed Link
Lefils-Lacourtablaise J et al. The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. 2013 PLoS ONE pmid:23734181
Li H and Narahara H 15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines. 2013 Int. J. Mol. Med. pmid:23403520
Marcone S and Fitzgerald DJ Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2. 2013 Proteomics pmid:23606334
Fernandez-Bustamante A et al. Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. 2013 Inflammation pmid:23616184
Sánchez-Gómez FJ et al. Modulation of GSTP1-1 oligomerization by electrophilic inflammatory mediators and reactive drugs. 2013 Inflamm Allergy Drug Targets pmid:23596995
Ramer R et al. COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells. 2013 Mol. Cancer Ther. pmid:23220503
Xu X et al. Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation. 2013 Steroids pmid:23707573
Liu H et al. Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. 2013 Neurotoxicology pmid:23973622
Tan BS et al. 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). 2013 Cancer Lett. pmid:23612072
Ramer R et al. Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. 2013 J. Lipid Res. pmid:23943857
Wang P et al. The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. 2012 J. Biol. Chem. pmid:22829602
Sykes L et al. Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes. 2012 PLoS ONE pmid:23226366
Alba G et al. Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. 2012 PLoS ONE pmid:23115616
Miyawaki T et al. Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. 2012 Immunopharmacol Immunotoxicol pmid:21854184
Lee E et al. 15-Deoxy-Δ12,14-prostaglandin J₂ modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes. 2012 Free Radic. Biol. Med. pmid:22245093
Fujita M et al. Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma. 2012 Int J Med Sci pmid:22991494
Matzkin ME et al. Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake. 2012 Gen. Comp. Endocrinol. pmid:22974512
Sykes L et al. Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. 2012 Mediators Inflamm. pmid:22690041
Raman P et al. 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. 2012 J. Pharmacol. Exp. Ther. pmid:22700433
Liu X et al. 15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. 2012 Eur. J. Cell Biol. pmid:22560326