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Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. |
2006 |
FEBS Lett. |
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15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism. |
2006 |
Toxicol. Appl. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. |
2006 |
Mol. Cancer Ther. |
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Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells. |
2006 |
Am. J. Physiol. Renal Physiol. |
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PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. |
2006 |
BMC Cancer |
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Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. |
2006 |
Mol. Cancer Res. |
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Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1. |
2006 |
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15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. |
2006 |
Life Sci. |
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Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. |
2006 |
Prostaglandins Other Lipid Mediat. |
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Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia. |
2006 |
Intensive Care Med |
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Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. |
2006 |
Mol. Pharmacol. |
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Arnold R and König W |
Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. |
2006 |
Virology |
pmid:16616290
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Merwald H et al. |
Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. |
2006 |
Cell Stress Chaperones |
pmid:16572732
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Arnold R and König W |
Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. |
2006 |
Virology |
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Kohno S et al. |
Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma. |
2006 |
Biomed. Pharmacother. |
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Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins. |
2006 |
Diabetes Obes Metab |
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15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. |
2006 |
Arterioscler. Thromb. Vasc. Biol. |
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ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. |
2006 |
Genes Cells |
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Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. |
2006 |
Am. J. Physiol. Heart Circ. Physiol. |
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Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. |
2006 |
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Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. |
2006 |
J. Cell. Biochem. |
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Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. |
2006 |
Cell. Signal. |
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Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. |
2006 |
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Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells. |
2006 |
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Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. |
2006 |
J. Am. Soc. Nephrol. |
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15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. |
2006 |
J. Cereb. Blood Flow Metab. |
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Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. |
2006 |
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Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. |
2006 |
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Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. |
2006 |
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PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. |
2006 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:16155101
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15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. |
2006 |
Neurochem. Res. |
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Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. |
2006 |
Carcinogenesis |
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Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. |
2006 |
J. Cereb. Blood Flow Metab. |
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Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives. |
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Chem Asian J |
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Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells. |
2006 |
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PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. |
2006 |
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2006 |
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Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). |
2006 |
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Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. |
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Mol. Pharmacol. |
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Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. |
2006 |
Anticancer Drugs |
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PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. |
2006 |
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15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. |
2006 |
Prostaglandins Other Lipid Mediat. |
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PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. |
2006 |
Prostaglandins Other Lipid Mediat. |
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Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. |
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Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. |
2006 |
J. Biol. Chem. |
pmid:16565077
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Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. |
2006 |
Biochem. Pharmacol. |
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Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia. |
2006 |
Cell Biochem. Biophys. |
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Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation. |
2006 |
Eur. J. Pharmacol. |
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15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. |
2006 |
Urology |
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The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. |
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BMC Mol. Biol. |
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Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. |
2006 |
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15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. |
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The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. |
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Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. |
2006 |
Biorheology |
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Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. |
2006 |
Shock |
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Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. |
2006 |
Cell. Physiol. Biochem. |
pmid:16914899
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15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors. |
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Biochem. Pharmacol. |
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Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. |
2006 |
Invest. Ophthalmol. Vis. Sci. |
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15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. |
2006 Nov-Dec |
Placenta |
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Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. |
2006 Sep-Oct |
J. Gastrointest. Surg. |
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Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. |
2007 |
Arch. Biochem. Biophys. |
pmid:17169324
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Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. |
2007 |
Immunol. Cell Biol. |
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Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. |
2007 |
Mol. Pharmacol. |
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Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice. |
2007 |
Int. J. Mol. Med. |
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15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. |
2007 |
J. Korean Med. Sci. |
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[Effect of peroxisome proliferators-activated receptor gamma ligands on cytotrophoblast invasion in first trimester pregnancy]. |
2007 |
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pmid:17983488
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Cyclooxygenase-independent inhibition of H2O2-induced cell death by S-ketoprofen in renal cells. |
2007 |
Pharmacol. Res. |
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Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. |
2007 |
Pharm. Res. |
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Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells. |
2007 |
Nephrol. Dial. Transplant. |
pmid:17255125
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Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. |
2007 |
Am. J. Pathol. |
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[Effect of peroxisome proliferators-activated receptor-gamma in the mechanisms of sulindac against large intestine carcinoma]. |
2007 |
Beijing Da Xue Xue Bao |
pmid:17304332
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[The effect of ligand of peroxisome proliferators-activated receptor gamma 15d-PGJ2 on the proliferation and activation of hepatic stellate cells]. |
2007 |
Zhonghua Gan Zang Bing Za Zhi |
pmid:17362636
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15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain. |
2007 |
Cancer Res. |
pmid:17363578
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15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. |
2007 |
J. Immunol. |
pmid:17371958
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Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. |
2007 |
Int. Arch. Allergy Immunol. |
pmid:17541271
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15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-alpha by decreasing levels of acetylated histone H3 and H4 at its promoter. |
2007 |
Biochem. Biophys. Res. Commun. |
pmid:17532302
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Vunta H et al. |
The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. |
2007 |
J. Biol. Chem. |
pmid:17439952
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Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. |
2007 |
Circ. Res. |
pmid:17463321
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15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. |
2007 |
Anticancer Drugs |
pmid:17159504
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Arnold R et al. |
Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. |
2007 |
Immunology |
pmid:17425601
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IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. |
2007 |
Eur. J. Immunol. |
pmid:17458857
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15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. |
2007 |
J Neuroinflammation |
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Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. |
2007 |
Prostaglandins Other Lipid Mediat. |
pmid:17643887
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PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. |
2007 |
Bone |
pmid:17669705
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Fionda C et al. |
Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes. |
2007 |
Mol. Pharmacol. |
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Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. |
2007 |
Eur. J. Pharmacol. |
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PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts. |
2007 |
Cardiovasc. Res. |
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Involvement of PPARgamma in human trophoblast invasion. |
2007 |
Placenta |
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An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells. |
2007 |
Toxicol. Sci. |
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Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. |
2007 |
J. Immunol. |
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Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. |
2007 |
Mol. Pharmacol. |
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15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. |
2007 |
Apoptosis |
pmid:17786557
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Brunoldi EM et al. |
Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. |
2007 |
Chem. Res. Toxicol. |
pmid:17854155
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Wu P et al. |
Inflammation pro-resolving potential of 3,4-dihydroxyacetophenone through 15-deoxy-delta12,14-prostaglandin J2 in murine macrophages. |
2007 |
Int. Immunopharmacol. |
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Saito Y et al. |
Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. |
2007 |
J. Neurochem. |
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Kondoh K et al. |
Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apoptosis in cancer cells. |
2007 |
Exp. Cell Res. |
pmid:17706193
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15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. |
2007 |
Exp. Cell Res. |
pmid:17707368
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Kamagata C et al. |
15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. |
2007 |
Breast Cancer Res. Treat. |
pmid:17028981
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