Zurich MG et al. |
Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. |
2005 |
Neuroscience |
pmid:15994020
|
Pena-dos-Santos DR et al. |
Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint. |
2009 |
Neuroscience |
pmid:19647045
|
Liu H et al. |
Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. |
2013 |
Neurotoxicology |
pmid:23973622
|
González E et al. |
Streptozotocin-pancreatic damage in the rat: modulatory effect of 15-deoxy delta12,14-prostaglandin j(2) on nitridergic and prostanoid pathway. |
2002 |
Nitric Oxide |
pmid:11890746
|
Burgermeister E et al. |
Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. |
2003 |
Oncogene |
pmid:12813462
|
Kar R et al. |
A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells. |
2009 |
Oncogene |
pmid:19448671
|
Kim DH et al. |
15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue. |
2010 |
Oncogene |
pmid:20208557
|
Crabb SJ et al. |
BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells. |
2008 |
Oncol. Rep. |
pmid:18288403
|
Takashima T et al. |
Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma. |
2005 |
Oncol. Rep. |
pmid:15756430
|
Yen CC et al. |
Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. |
2014 |
Oncotarget |
pmid:24566468
|
Yuan J et al. |
M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway. |
2017 |
Oncotarget |
pmid:28423639
|
Brummond KM et al. |
The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry. |
2004 |
Org. Lett. |
pmid:14723515
|
Fahmi H et al. |
15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. |
2002 |
Osteoarthr. Cartil. |
pmid:12435328
|
Masamune A et al. |
Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells. |
2002 |
Pancreas |
pmid:11854617
|
Hashimoto K et al. |
Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. |
2004 |
Pancreas |
pmid:15028947
|
Hashimoto K et al. |
The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. |
2003 |
Pancreas |
pmid:12826907
|
Hagens WI et al. |
Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. |
2007 |
Pharm. Res. |
pmid:17245650
|
Reyes-Martin P et al. |
Cyclooxygenase-independent inhibition of H2O2-induced cell death by S-ketoprofen in renal cells. |
2007 |
Pharmacol. Res. |
pmid:17291778
|
Reyes-Martin P et al. |
15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism. |
2008 |
Pharmacol. Res. |
pmid:18456507
|
Wung BS et al. |
Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. |
2006 |
Pharmacol. Res. |
pmid:16243536
|
Azuma Y et al. |
Induction of proliferation by 15-deoxy-delta12,14-prostaglandin J2 and the precursors in monocytic leukemia U937. |
2004 |
Pharmacology |
pmid:15240994
|
Lappas M et al. |
Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranes. |
2004 Sep-Oct |
Placenta |
pmid:15450387
|
Suwaki N et al. |
Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. |
2007 |
Placenta |
pmid:16753211
|
Fournier T et al. |
Involvement of PPARgamma in human trophoblast invasion. |
2007 |
Placenta |
pmid:17321592
|
Moore RM et al. |
Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. |
2003 Feb-Mar |
Placenta |
pmid:12566244
|
Lappas M et al. |
15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. |
2006 Nov-Dec |
Placenta |
pmid:16434095
|
Lefils-Lacourtablaise J et al. |
The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. |
2013 |
PLoS ONE |
pmid:23734181
|
Sykes L et al. |
Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes. |
2012 |
PLoS ONE |
pmid:23226366
|
Gao D et al. |
Rosiglitzone suppresses angiotensin II-induced production of KLF5 and cell proliferation in rat vascular smooth muscle cells. |
2015 |
PLoS ONE |
pmid:25874449
|
Xu F et al. |
Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. |
2013 |
PLoS ONE |
pmid:23372817
|
Wang P et al. |
Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. |
2011 |
PLoS ONE |
pmid:22096605
|
Alba G et al. |
Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. |
2012 |
PLoS ONE |
pmid:23115616
|
Paulitschke V et al. |
Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. |
2012 |
PLoS ONE |
pmid:23049949
|
Yamamoto Y et al. |
Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane. |
2011 |
PLoS ONE |
pmid:21445266
|
Savinainen JR et al. |
Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). |
2014 |
PLoS ONE |
pmid:25290914
|
Samikkannu T et al. |
Immunopathogenesis of HIV infection in cocaine users: role of arachidonic acid. |
2014 |
PLoS ONE |
pmid:25171226
|
Kanakasabai S et al. |
PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. |
2012 |
PLoS ONE |
pmid:23185633
|
Buckner MM et al. |
15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium. |
2013 |
PLoS ONE |
pmid:23922794
|
Liu L et al. |
Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. |
2013 |
PLoS ONE |
pmid:24023668
|
Sharvit E et al. |
Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists. |
2013 |
PLoS ONE |
pmid:24098526
|
Kim KR et al. |
15-deoxy-δ12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss. |
2015 |
PLoS ONE |
pmid:25859665
|
Seno T et al. |
15-Deoxy-Δ¹²,¹ⴠprostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. |
2011 |
PLoS ONE |
pmid:22003398
|
de Jong E et al. |
Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. |
2011 |
PLoS ONE |
pmid:21957481
|
Li H and Pauza CD |
Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells. |
2009 |
PLoS ONE |
pmid:19888466
|
Khanim FL et al. |
Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. |
2009 |
PLoS ONE |
pmid:19997560
|
de Melo NF et al. |
15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation. |
2016 |
PLoS ONE |
pmid:27575486
|
Kliewer SA et al. |
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. |
1997 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9113987
|
Koharudin LM et al. |
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:20231490
|
Straus DS et al. |
15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10781090
|
Murata T et al. |
Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. |
2011 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:22106279
|
Kondo M et al. |
15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. |
2002 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12032289
|
Rossi A et al. |
Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation. |
1997 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9012856
|
Rajakariar R et al. |
Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:18077391
|
Petrova TV et al. |
Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. |
1999 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10200320
|
Haworth O and Buckley CD |
Resolving the problem of persistence in the switch from acute to chronic inflammation. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:18093938
|
Eggler AL et al. |
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16006525
|
Oliva JL et al. |
The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12684535
|
Kim KA et al. |
15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. |
2005 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16098720
|
Imaizumi T et al. |
Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells. |
2003 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:14580366
|
Berry EB et al. |
Differential effects of serum constituents on apoptosis induced by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in WISH epithelial cells. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15253890
|
Garcia Palacios V et al. |
Expression of adipogenesis markers in a murine stromal cell line treated with 15-deoxy Delta(12,14)-prostaglandin J2, interleukin-11, 9-cis retinoic acid and vitamin K2. |
2001 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:11728175
|
Levine L |
Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors. |
2001 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:11728177
|
Keelan J et al. |
15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells. |
2001 |
Prostaglandins Other Lipid Mediat. |
pmid:11785780
|
Funovics P et al. |
Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16647637
|
Józkowicz A et al. |
15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. |
2004 |
Prostaglandins Other Lipid Mediat. |
pmid:15560113
|
Chowdhury AA et al. |
15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. |
2011 |
Prostaglandins Other Lipid Mediat. |
pmid:21699992
|
Wang JJ and Mak OT |
Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARγ activation in non-small cell lung carcinoma A549 cells. |
2011 |
Prostaglandins Other Lipid Mediat. |
pmid:21396480
|
Maxey KM et al. |
The nature and composition of 15-deoxy-Delta(12,14)PGJ(2). |
2000 |
Prostaglandins Other Lipid Mediat. |
pmid:10936412
|
Clay CE et al. |
15-deoxy-Delta(12,14)PGJ(2) induces diverse biological responses via PPARgamma activation in cancer cells. |
2000 |
Prostaglandins Other Lipid Mediat. |
pmid:10936413
|
Imaizumi T et al. |
15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide. |
2003 |
Prostaglandins Other Lipid Mediat. |
pmid:14518569
|
Ye Y et al. |
Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. |
2007 |
Prostaglandins Other Lipid Mediat. |
pmid:17643887
|
Willermain F et al. |
15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16939878
|
Lim HJ et al. |
PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. |
2006 |
Prostaglandins Other Lipid Mediat. |
pmid:16939881
|
Imaizumi T et al. |
Effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of retinoic acid-inducible gene-I in endothelial cells stimulated with lipopolysaccharide. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:16303604
|
Marcone S and Fitzgerald DJ |
Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2. |
2013 |
Proteomics |
pmid:23606334
|
GarcÃa-Bueno B et al. |
The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. |
2005 |
Psychopharmacology (Berl.) |
pmid:15719215
|
Wang X et al. |
Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. |
2009 |
Pulm Pharmacol Ther |
pmid:19489131
|
Wall SB et al. |
Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. |
2015 |
Redox Biol |
pmid:25677088
|
Higashihara H et al. |
Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. |
2004 |
Redox Rep. |
pmid:15720834
|
Takagi T et al. |
A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. |
2004 |
Redox Rep. |
pmid:15720836
|
Bogacka I et al. |
The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. |
2013 |
Reprod Biol |
pmid:24287039
|
Capobianco E et al. |
15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. |
2005 |
Reprod. Fertil. Dev. |
pmid:15899154
|
Jawerbaum A et al. |
Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis. |
2005 |
Reproduction |
pmid:16264098
|
Jawerbaum A et al. |
Modulation of nitric oxide concentration and lipid metabolism by 15-deoxy Delta12,14prostaglandin J2 in embryos from control and diabetic rats during early organogenesis. |
2002 |
Reproduction |
pmid:12417000
|
Yin Y et al. |
PPARγ agonists regulate tobacco smoke-induced Toll like receptor 4 expression in alveolar macrophages. |
2014 |
Respir. Res. |
pmid:24612634
|
Ji JD et al. |
Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. |
2005 |
Rheumatology (Oxford) |
pmid:15840591
|
Martinez-Cengotitabengoa M et al. |
BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. |
2016 |
Schizophr Bull |
pmid:26130821
|
GarcÃa-Bueno B et al. |
Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. |
2014 |
Schizophr Bull |
pmid:23486748
|
MartÃnez-Gras I et al. |
The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. |
2011 |
Schizophr. Res. |
pmid:21334179
|
Shibata T et al. |
Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. |
2016 |
Sci Rep |
pmid:26879669
|
Guan PP et al. |
The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage. |
2015 |
Sci Rep |
pmid:25992485
|
Garza LA et al. |
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. |
2012 |
Sci Transl Med |
pmid:22440736
|
Abdelrahman M et al. |
The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. |
2004 |
Shock |
pmid:15545828
|
Hickson-Bick DL et al. |
The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. |
2006 |
Shock |
pmid:16680021
|
Genovese T et al. |
Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. |
2008 |
Shock |
pmid:18628687
|
Monroy MA et al. |
THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. |
2007 |
Shock |
pmid:17510607
|
Zingarelli B et al. |
Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. |
2007 |
Shock |
pmid:17589386
|
Kaplan J et al. |
Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. |
2007 |
Shock |
pmid:17621259
|
Piraino G et al. |
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
Shock |
pmid:16878022
|
Hovsepian E et al. |
15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. |
2010 |
Shock |
pmid:19997048
|