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Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. |
2006 |
J. Neuroimmunol. |
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15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. |
2006 |
J. Neurochem. |
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The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. |
2006 |
J. Immunol. |
pmid:17015690
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Piraino G et al. |
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
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Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. |
2005 Nov-Dec |
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Aspirin modulates LPS-induced nitric oxide release in rat glial cells. |
2005 Jun 10-17 |
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Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2. |
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Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. |
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Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. |
2005 |
Am. J. Respir. Crit. Care Med. |
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Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. |
2005 |
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Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. |
2005 |
J. Pharmacol. Exp. Ther. |
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Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. |
2005 |
Am. J. Physiol., Cell Physiol. |
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The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. |
2005 |
J. Hepatol. |
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15d-PGJ2: the anti-inflammatory prostaglandin? |
2005 |
Clin. Immunol. |
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Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. |
2005 |
Ann. Oncol. |
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Coyle AT et al. |
15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells. |
2005 |
FEBS J. |
pmid:16156795
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O'Flaherty JT et al. |
5-Oxo-ETE analogs and the proliferation of cancer cells. |
2005 |
Biochim. Biophys. Acta |
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Jawerbaum A et al. |
Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis. |
2005 |
Reproduction |
pmid:16264098
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15-Deoxy-delta12,14-prostaglandin J2, a neuroprotectant or a neurotoxicant? |
2005 |
Toxicology |
pmid:16191461
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Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:16198309
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ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. |
2005 |
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CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. |
2005 |
Eur. J. Pharmacol. |
pmid:16256979
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The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. |
2005 |
Exp. Neurol. |
pmid:16061222
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Kim KA et al. |
15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. |
2005 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:16098720
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Stahlschmidt J et al. |
Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. |
2005 |
Kidney Int. |
pmid:16105033
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PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. |
2005 |
Blood |
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The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. |
2005 |
J. Lipid Res. |
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Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:15694358
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Shiraki T et al. |
Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. |
2005 |
J. Biol. Chem. |
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The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. |
2005 |
Psychopharmacology (Berl.) |
pmid:15719215
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Storer PD et al. |
Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. |
2005 |
J. Neurosci. Res. |
pmid:15723383
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Migita H and Morser J |
15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression. |
2005 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:15662020
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Tanaka T et al. |
Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. |
2005 |
Eur. J. Pharmacol. |
pmid:15680279
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Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. |
2005 |
Thromb. Haemost. |
pmid:15886792
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Li X et al. |
Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. |
2005 |
J. Rheumatol. |
pmid:15868626
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Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. |
2005 |
J. Lab. Clin. Med. |
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Planagumà A et al. |
The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. |
2005 |
FASEB J. |
pmid:15876570
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Kim HY et al. |
Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. |
2005 |
Immunol. Cell Biol. |
pmid:15877607
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Capobianco E et al. |
15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. |
2005 |
Reprod. Fertil. Dev. |
pmid:15899154
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Patel KM et al. |
Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). |
2005 |
Cell. Signal. |
pmid:15993751
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Zurich MG et al. |
Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. |
2005 |
Neuroscience |
pmid:15994020
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Kim HJ et al. |
15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes. |
2005 |
Exp. Mol. Med. |
pmid:16000871
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Pande V and Ramos MJ |
Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:16006125
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Eggler AL et al. |
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16006525
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Matsuzaki Y et al. |
15-deoxy-Delta12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor. |
2005 |
Int. J. Oncol. |
pmid:16010433
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Kaplan JM et al. |
15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. |
2005 |
Shock |
pmid:15988322
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Tomita H et al. |
Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells. |
2005 |
Cardiovasc. Res. |
pmid:15949477
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Maurin AC et al. |
Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids. |
2005 |
Calcif. Tissue Int. |
pmid:15868283
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Inoue K et al. |
Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. |
2005 |
Clin. Exp. Pharmacol. Physiol. |
pmid:15743408
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Lindström TM and Bennett PR |
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. |
2005 |
J. Clin. Endocrinol. Metab. |
pmid:15755849
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