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The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. |
2005 |
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15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. |
2005 |
Mol. Pharmacol. |
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15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. |
2005 |
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2005 |
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PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. |
2005 |
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Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. |
2006 |
Carcinogenesis |
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5-Oxo-ETE analogs and the proliferation of cancer cells. |
2005 |
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2006 |
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2005 Nov-Dec |
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2005 |
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2006 |
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Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2. |
2006 |
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2005 |
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2006 |
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ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. |
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CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. |
2005 |
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2005 |
Reproduction |
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2006 |
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Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2. |
2005 |
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Identification of novel protein targets for modification by 15-deoxy-Delta12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. |
2006 |
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Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production. |
2005 |
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2005 |
Prostaglandins Other Lipid Mediat. |
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The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation. |
2005 |
Genes Cells |
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Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. |
2006 |
Virology |
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Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma. |
2006 |
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Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins. |
2006 |
Diabetes Obes Metab |
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2006 |
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2006 |
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Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1. |
2006 |
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15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. |
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15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. |
2006 Nov-Dec |
Placenta |
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Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia. |
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2006 |
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15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. |
2006 |
Urology |
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Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. |
2006 |
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15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. |
2006 |
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Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. |
2006 |
Biochem. Pharmacol. |
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PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. |
2006 |
BMC Cancer |
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Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia. |
2006 |
Intensive Care Med |
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Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. |
2006 |
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Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. |
2006 |
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Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. |
2006 |
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Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells. |
2006 |
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Peroxisome proliferator-activated receptors and acute lung injury. |
2006 |
Curr Opin Pharmacol |
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Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions. |
2006 |
Endocr. Relat. Cancer |
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Mol. Pharmacol. |
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Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. |
2006 |
Mol. Pharmacol. |
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Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. |
2006 |
Virology |
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Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. |
2006 |
Prostaglandins Other Lipid Mediat. |
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Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection. |
2006 |
Mol. Carcinog. |
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The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. |
2006 |
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2006 |
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PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. |
2006 |
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2006 |
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Rosiglitazone ameliorates cisplatin-induced renal injury in mice. |
2006 |
Nephrol. Dial. Transplant. |
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15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells. |
2006 |
Exp. Cell Res. |
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Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. |
2007 |
Placenta |
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2006 |
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Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. |
2006 |
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Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. |
2006 |
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Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. |
2006 |
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ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. |
2006 |
Genes Cells |
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PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. |
2006 |
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Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. |
2006 |
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Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). |
2006 |
Am. J. Nephrol. |
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Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
Shock |
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15-deoxy-Delta12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism. |
2006 |
Toxicol. Appl. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. |
2006 |
Mol. Cancer Ther. |
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Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells. |
2006 |
Am. J. Physiol. Renal Physiol. |
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Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. |
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Mol. Pharmacol. |
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Effect of peroxisome proliferator activated receptor (PPAR)gamma agonists on prostaglandins cascade in joint cells. |
2006 |
Biorheology |
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Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. |
2006 |
Shock |
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Quantitative characterization of 15-deoxy-delta(12,14)-prostaglandin J2 in regulating EGFPSmad2 translocation in CHO cells through PPARgamma/TGFbeta/Smad2 pathway. |
2006 |
Cell. Physiol. Biochem. |
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Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. |
2006 |
Anticancer Drugs |
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15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. |
2006 |
Prostaglandins Other Lipid Mediat. |
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PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. |
2006 |
Prostaglandins Other Lipid Mediat. |
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Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. |
2006 Sep-Oct |
J. Gastrointest. Surg. |
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Addition of electrophilic lipids to actin alters filament structure. |
2006 |
Biochem. Biophys. Res. Commun. |
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15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors. |
2006 |
Biochem. Pharmacol. |
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Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. |
2006 |
Am. J. Pathol. |
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15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells. |
2006 |
Neurochem. Res. |
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The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. |
2006 |
J. Immunol. |
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15-deoxy-Delta(12,14)-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression. |
2007 |
Breast Cancer Res. Treat. |
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Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. |
2006 |
Invest. Ophthalmol. Vis. Sci. |
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15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. |
2006 |
J. Neurochem. |
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Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. |
2007 |
Immunol. Cell Biol. |
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Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice. |
2007 |
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Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. |
2006 |
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Endogenous 15-deoxy-Delta(12,14)-prostaglandin J(2) synthesized by adipocytes during maturation phase contributes to upregulation of fat storage. |
2006 |
FEBS Lett. |
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Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. |
2007 |
Mol. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors. |
2007 |
Anticancer Drugs |
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Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. |
2007 |
Life Sci. |
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Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. |
2007 |
Arch. Biochem. Biophys. |
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Peroxisome proliferator-activated receptor-gamma is expressed by rat peritoneal mesothelial cells: its potential role in peritoneal cavity local defense. |
2006 |
Am. J. Nephrol. |
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