| MeSH term | MeSH ID | Detail |
|---|---|---|
| Graves Ophthalmopathy | D049970 | 3 associated lipids |
| Leukemia, B-Cell | D015448 | 3 associated lipids |
| Goiter | D006042 | 4 associated lipids |
| Actinobacillus Infections | D000189 | 4 associated lipids |
| Lymphoma, T-Cell | D016399 | 11 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
15-deoxy-delta-12,14-PGJ2
15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-deoxy-delta-12,14-PGJ2?
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
PubChem Associated disorders and diseases
What pathways are associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 15-deoxy-delta-12,14-PGJ2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ramachandran L et al. | Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. | 2012 | J. Biol. Chem. | pmid:22992727 |
| Alba G et al. | Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. | 2012 | PLoS ONE | pmid:23115616 |
| Hossain MS et al. | Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids. | 2012 | Exp. Cell Res. | pmid:22100987 |
| Gates D et al. | Apo J/clusterin expression and secretion: evidence for 15-deoxy-Δ(12,14)-PGJ(2)-dependent mechanism. | 2012 | Biochim. Biophys. Acta | pmid:22138303 |
| Bardelli C et al. | Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands. | 2012 | Br. J. Pharmacol. | pmid:21745193 |
| Miyawaki T et al. | Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854184 |
| Pasvanis S et al. | High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ(12,14)-prostaglandin J(2) on the resistance to saquinavir. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22293191 |
| Duan Y et al. | Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. | 2012 | J. Biol. Chem. | pmid:22593575 |
| Springstead JR et al. | Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function. | 2012 | J. Lipid Res. | pmid:22550136 |
| He S et al. | Identification, organ expression and ligand-dependent expression levels of peroxisome proliferator activated receptors in grass carp (Ctenopharyngodon idella). | 2012 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:22079418 |
| Clemente-Napimoga JT et al. | 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. | 2012 | Life Sci. | pmid:22564409 |
| Lee E et al. | 15-Deoxy-Δ12,14-prostaglandin J₂ modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes. | 2012 | Free Radic. Biol. Med. | pmid:22245093 |
| Baek K et al. | Myeloid Elf-1-like factor stimulates adipogenic differentiation through the induction of peroxisome proliferator-activated receptor γ expression in bone marrow. | 2012 | J. Cell. Physiol. | pmid:22307523 |
| MartÃnez AE et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 exerts pro- and anti-inflammatory effects in mesangial cells in a concentration-dependent manner. | 2012 | Inflamm Allergy Drug Targets | pmid:22309084 |
| Fujita M et al. | Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma. | 2012 | Int J Med Sci | pmid:22991494 |
| Farnesi-de-Assunção TS et al. | PPAR-γ agonists, mainly 15d-PGJ(2), reduce eosinophil recruitment following allergen challenge. | 2012 | Cell. Immunol. | pmid:22192475 |
| Kuriyan AE et al. | Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring. | 2012 | Exp. Eye Res. | pmid:22178289 |
| Abdo H et al. | The omega-6 fatty acid derivative 15-deoxy-Δ¹²,¹â´-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress. | 2012 | J. Physiol. (Lond.) | pmid:22473776 |
| Garza LA et al. | Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. | 2012 | Sci Transl Med | pmid:22440736 |
| Cloutier A et al. | The prostanoid 15-deoxy-Δ12,14-prostaglandin-j2 reduces lung inflammation and protects mice against lethal influenza infection. | 2012 | J. Infect. Dis. | pmid:22219346 |
| Napimoga MH et al. | Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. | 2012 | J. Immunol. | pmid:22706081 |
| Syeda PK et al. | Generation of monoclonal antibody for 15-deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚ and development of enzyme-linked immunosorbent assay for its quantification in culture medium of adipocytes. | 2012 | Appl. Biochem. Biotechnol. | pmid:22391692 |
| Quinteiro MS et al. | The indirect antinociceptive mechanism of 15d-PGJ2 on rheumatoid arthritis-induced TMJ inflammatory pain in rats. | 2012 | Eur J Pain | pmid:22354681 |
| Prage EB et al. | Observation of two modes of inhibition of human microsomal prostaglandin E synthase 1 by the cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2). | 2012 | Biochemistry | pmid:22356188 |
| Numazawa S et al. | Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. | 2012 | Biol. Pharm. Bull. | pmid:22382320 |
| Lin YC et al. | The glutathionylation of p65 modulates NF-κB activity in 15-deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-treated endothelial cells. | 2012 | Free Radic. Biol. Med. | pmid:22387200 |
| Kim YI et al. | Effects of 15-deoxy-∆¹²,¹â´-prostaglandin Jâ‚‚ on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. | 2011 | Mol. Biol. Rep. | pmid:20174873 |
| Lotz C et al. | Peroxisome-proliferator-activated receptor γ mediates the second window of anaesthetic-induced preconditioning. | 2011 | Exp. Physiol. | pmid:21123361 |
| Tsujita T et al. | Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish. | 2011 | Genes Cells | pmid:21143560 |
| Neri T et al. | Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles. | 2011 | Eur. Respir. J. | pmid:21148223 |
| Tobiasova Z et al. | Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. | 2011 | Circulation | pmid:21690493 |
| Ulivi V et al. | Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. | 2011 | Arthritis Res. Ther. | pmid:21682897 |
| Yamamoto Y et al. | 15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683069 |
| Wang P et al. | Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. | 2011 | PLoS ONE | pmid:22096605 |
| Maekawa N et al. | High-performance affinity purification for identification of 15-deoxy-Δ 12,14 -PGJ₂ interacting factors using magnetic nanobeads. | 2011 | Biomed. Chromatogr. | pmid:21374648 |
| Kane CJ et al. | Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists. | 2011 | Brain Behav. Immun. | pmid:21376806 |
| MartÃnez-Gras I et al. | The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. | 2011 | Schizophr. Res. | pmid:21334179 |
| Chbicheb S et al. | EGR1 expression: a calcium and ERK1/2 mediated PPARγ-independent event involved in the antiproliferative effect of 15-deoxy-Δ12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells. | 2011 | Biochem. Pharmacol. | pmid:21338579 |
| Murata T et al. | Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106279 |
| Du H et al. | Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. | 2011 | Br. J. Pharmacol. | pmid:21501147 |
| Lin TH et al. | 15-deoxy-Δ(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts. | 2011 | J. Cell. Physiol. | pmid:21344384 |
| Bräutigam K et al. | Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20878528 |
| Song NY et al. | Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells. | 2011 | Chem. Res. Toxicol. | pmid:21728338 |
| Gandhi UH et al. | Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma. | 2011 | J. Biol. Chem. | pmid:21669866 |
| Charles RL et al. | Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. | 2011 | Circ. Res. | pmid:21164107 |
| Tang FT et al. | Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression. | 2011 | Eur. J. Pharmacol. | pmid:20854809 |
| Hardy KD et al. | Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. | 2011 | J. Lipid Res. | pmid:20944061 |
| Li N et al. | Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. | 2011 | J. Cell. Biochem. | pmid:21268089 |
| Wang JJ and Mak OT | Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGDâ‚‚ metabolite, 15d-PGJâ‚‚. | 2011 | Cell Biol. Int. | pmid:21999315 |
| Seno T et al. | 15-Deoxy-Δ¹²,¹ⴠprostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. | 2011 | PLoS ONE | pmid:22003398 |