15-deoxy-delta-12,14-PGJ2

15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-deoxy-delta-12,14-PGJ2?

15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2

MeSH term MeSH ID Detail
Actinobacillus Infections D000189 4 associated lipids
Arteriosclerosis D001161 86 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Fibrosis D005355 23 associated lipids
Goiter D006042 4 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperalgesia D006930 42 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Neoplasms D008175 171 associated lipids
Myocardial Infarction D009203 21 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 | Total 30

PubChem Associated disorders and diseases

What pathways are associated with 15-deoxy-delta-12,14-PGJ2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 15-deoxy-delta-12,14-PGJ2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 15-deoxy-delta-12,14-PGJ2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 15-deoxy-delta-12,14-PGJ2

Download all related citations
Per page 10 20 50 100 | Total 940
Authors Title Published Journal PubMed Link
Kasim-Karakas SE et al. Metabolic and endocrine effects of a polyunsaturated fatty acid-rich diet in polycystic ovary syndrome. 2004 J. Clin. Endocrinol. Metab. pmid:14764771
Ray DM et al. Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. 2004 Clin. Immunol. pmid:15451478
Emi M and Maeyama K The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. 2004 Biochem. Pharmacol. pmid:15013841
Diab A et al. Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. 2004 J. Neuroimmunol. pmid:14975592
Paumi CM et al. Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). 2004 Biochemistry pmid:14979731
Relic B et al. 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. 2004 J. Biol. Chem. pmid:15004016
Liu JD et al. Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. 2004 Life Sci. pmid:14998722
Sabichi AL et al. Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. 2004 Cancer Epidemiol. Biomarkers Prev. pmid:15533896
Subbarayan V et al. Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. 2004 Cancer Epidemiol. Biomarkers Prev. pmid:15533897
Giri S et al. The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. 2004 J. Immunol. pmid:15470065
Huang H et al. Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. 2004 Mol. Cancer Res. pmid:15498928
Asami-Miyagishi R et al. Expression and function of PPARgamma in rat placental development. 2004 Biochem. Biophys. Res. Commun. pmid:14766236
Mix KS et al. Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. 2004 Mol. Pharmacol. pmid:14742672
Lee KJ et al. Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. 2004 Exp. Mol. Med. pmid:15665586
Maddox JF et al. 15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes. 2004 Toxicol. Sci. pmid:14657518
Ehara N et al. Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. 2004 Biochem. Biophys. Res. Commun. pmid:15358182
Li L et al. Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts. 2004 J. Hepatol. pmid:15336443
Weber SM et al. PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. 2004 Am. J. Physiol. Endocrinol. Metab. pmid:15315910
Siavash H et al. Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. 2004 Br. J. Cancer pmid:15316561
Sánchez-Gómez FJ et al. Protein thiol modification by 15-deoxy-Delta12,14-prostaglandin J2 addition in mesangial cells: role in the inhibition of pro-inflammatory genes. 2004 Mol. Pharmacol. pmid:15317873
Lim SY et al. 15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. 2004 J. Biol. Chem. pmid:15319433
Ichiki T et al. 15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. 2004 Biochem. Biophys. Res. Commun. pmid:15369766
Si Q et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. 2004 J. Immunol. pmid:15322215
Cheng J et al. Peroxisome proliferator-activated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells. 2004 Biochem. Biophys. Res. Commun. pmid:15325252
Park KS et al. Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. 2004 Exp. Cell Res. pmid:15212945
Leung WK et al. Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. 2004 Gut pmid:14960510
Mouihate A et al. A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain. 2004 J. Neurosci. pmid:14960602
Chatterjee PK et al. The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. 2004 Cardiovasc. Res. pmid:14962493
Moore RM et al. Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. 2003 Feb-Mar Placenta pmid:12566244
Yuan ZY et al. [Peroxisome proliferation-activated receptor-gamma ligands ameliorate autoimmune myocarditis associated with inhibition of T cell immunity]. 2003 Zhonghua Yi Xue Za Zhi pmid:14703419
Ceaser EK et al. Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12881207
Pritts EA et al. Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element. 2003 Fertil. Steril. pmid:12909507
Zhang M et al. [Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-gamma and its mechanism]. 2003 Zhonghua Yi Xue Za Zhi pmid:12921638
Li L et al. Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. 2003 Gastroenterology pmid:12891549
Vosseler CA et al. Structural requirements of cyclopentenone prostaglandins to induce endothelial cell apoptosis. 2003 Biochem. Biophys. Res. Commun. pmid:12859958
Aoun P et al. Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells. 2003 Eur. J. Pharmacol. pmid:12860474
Zahradka P et al. Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation. 2003 Mol. Cell. Biochem. pmid:12841350
Yang L et al. Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. 2003 J. Biol. Chem. pmid:12829715
Houston KD et al. Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. 2003 Cancer Res. pmid:12649180
Lee TS et al. Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. 2003 J. Biol. Chem. pmid:12642589
Hashimoto K et al. The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. 2003 Pancreas pmid:12826907
Zingarelli B et al. Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. 2003 J. Immunol. pmid:14662889
Inoue K et al. Effect of 15-deoxy-delta 12,14-prostaglandin J2 on acute lung injury induced by lipopolysaccharide in mice. 2003 Eur. J. Pharmacol. pmid:14642794
Farrow B et al. Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator. 2003 Surgery pmid:12947319
Patel HJ et al. Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. 2003 J. Immunol. pmid:12594295
Cuzzocrea S et al. The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. 2003 Br. J. Pharmacol. pmid:12598422
Castrillo A et al. Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. 2003 Mol. Cell. Biol. pmid:12556480
Jung KM et al. Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-delta12,14-prostaglandin J2. 2003 Mol. Pharmacol. pmid:12606768
Abe M et al. GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12615657
Wanichkul T et al. Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. 2003 Fertil. Steril. pmid:12620489