| MeSH term | MeSH ID | Detail |
|---|---|---|
| Actinobacillus Infections | D000189 | 4 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Goiter | D006042 | 4 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
15-deoxy-delta-12,14-PGJ2
15-deoxy-delta-12,14-pgj2 is a lipid of Fatty Acyls (FA) class. 15-deoxy-delta-12,14-pgj2 is associated with abnormalities such as Dehydration and Myocardial Ischemia. The involved functions are known as Binding (Molecular Function), Inflammation, Alveolar ventilation function, Stimulus and Process. 15-deoxy-delta-12,14-pgj2 often locates in Cytosol, Myocardial tissue and Heart tissue. The associated genes with 15-deoxy-delta-12,14-PGJ2 are Homologous Gene and G-substrate. The related lipids are 15-deoxyprostaglandin J2 and Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of 15-deoxy-delta-12,14-PGJ2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-deoxy-delta-12,14-PGJ2?
15-deoxy-delta-12,14-PGJ2 is suspected in Dehydration, Myocardial Ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-deoxy-delta-12,14-PGJ2
PubChem Associated disorders and diseases
What pathways are associated with 15-deoxy-delta-12,14-PGJ2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-deoxy-delta-12,14-PGJ2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-deoxy-delta-12,14-PGJ2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-deoxy-delta-12,14-PGJ2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 15-deoxy-delta-12,14-PGJ2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Harris SG and Phipps RP | Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. | 2002 | Immunology | pmid:11849312 |
| Fu Y et al. | Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. | 2002 | Atherosclerosis | pmid:11755918 |
| Shibata T et al. | 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. | 2002 | J. Biol. Chem. | pmid:11786541 |
| Harris SG et al. | 15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. | 2002 | J. Immunol. | pmid:11801678 |
| Diaz BL et al. | Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. | 2002 | J. Immunol. | pmid:11801681 |
| Masamune A et al. | Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells. | 2002 | J. Biol. Chem. | pmid:11606585 |
| Chen SY et al. | 15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. | 2002 | Anticancer Drugs | pmid:12187333 |
| Miyazaki Y et al. | Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12150985 |
| Kondo M et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032289 |
| Sawano H et al. | 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. | 2002 | Kidney Int. | pmid:12028436 |
| Ward C et al. | Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. | 2002 | J. Immunol. | pmid:12055237 |
| Lennon AM et al. | MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species. | 2002 | J. Biol. Chem. | pmid:12052825 |
| Eligini S et al. | 15-deoxy-delta12,14-Prostaglandin J2 inhibits tissue factor expression in human macrophages and endothelial cells: evidence for ERK1/2 signaling pathway blockade. | 2002 | Thromb. Haemost. | pmid:12353085 |
| Campo PA et al. | Translational regulation of cyclin D1 by 15-deoxy-delta(12,14)-prostaglandin J(2). | 2002 | Cell Growth Differ. | pmid:12354750 |
| Mössner R et al. | Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma. | 2002 | J. Invest. Dermatol. | pmid:12230498 |
| Haslmayer P et al. | The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. | 2002 | Int. J. Oncol. | pmid:12239635 |
| Nencioni A et al. | Cyclopentenone prostaglandins induce caspase activation and apoptosis in dendritic cells by a PPAR-gamma-independent mechanism: regulation by inflammatory and T cell-derived stimuli. | 2002 | Exp. Hematol. | pmid:12225793 |
| Li L et al. | 15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. | 2001 | J. Biol. Chem. | pmid:11477100 |
| Davies GF et al. | Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism. | 2001 | Biochem. Pharmacol. | pmid:11597575 |
| Subbaramaiah K et al. | Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300. | 2001 | J. Biol. Chem. | pmid:11278336 |
| Keelan J et al. | 15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785780 |
| Pignatelli M et al. | The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells. | 2001 | J. Cell. Sci. | pmid:11739643 |
| Takeda K et al. | 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. | 2001 | J. Biol. Chem. | pmid:11687581 |
| Harris SG and Phipps RP | The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. | 2001 | Eur. J. Immunol. | pmid:11298334 |
| Tomlinson JW et al. | Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. | 2001 | Endocrinology | pmid:11316764 |
| Thévenon C et al. | Gas chromatographic-mass spectrometric measurement of 15-deoxy-delta(12,14)-prostaglandin J(2), the peroxisome proliferator-activated receptor gamma ligand, in urine. | 2001 | Clin. Chem. | pmid:11274037 |
| Rohn TT et al. | 15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis. | 2001 | Neuroreport | pmid:11277593 |
| Drew PD and Chavis JA | The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. | 2001 | J. Neuroimmunol. | pmid:11282151 |
| Guyton K et al. | Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation. | 2001 | J. Leukoc. Biol. | pmid:11310850 |
| Tsubouchi Y et al. | Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11350047 |
| Jiang JG et al. | Peroxisome proliferator-activated receptor gamma-mediated transcriptional up-regulation of the hepatocyte growth factor gene promoter via a novel composite cis-acting element. | 2001 | J. Biol. Chem. | pmid:11292834 |
| Serghides L and Kain KC | Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. | 2001 | J. Immunol. | pmid:11359831 |
| Buechler C et al. | Adipophilin is a sensitive marker for lipid loading in human blood monocytes. | 2001 | Biochim. Biophys. Acta | pmid:11420178 |
| Park JM | Role of prostaglandins in bladder smooth muscle cell gene expression. | 2001 | Urology | pmid:11378068 |
| Chen NG and Han X | Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401521 |
| Serhan CN and Devchand PR | Novel antiinflammatory targets for asthma. A role for PPARgamma? | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415929 |
| Wang AC et al. | Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415933 |
| Zhang X et al. | Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2. | 2001 | J. Immunol. | pmid:11390455 |
| Azuma Y et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-10 and IL-12 production by macrophages. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11327705 |
| Satoh K et al. | Lipid peroxidation end products-responded induction of a preneoplastic marker enzyme glutathione S-transferase P-form (GST-P) in rat liver on admistration via the portal vein. | 2001 | Mutat. Res. | pmid:11600134 |
| Yamamoto K et al. | Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes. | 2001 | Circulation | pmid:11581147 |
| Inoue K et al. | Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11563856 |
| Chiba Y et al. | PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11511093 |
| Nakashiro KI et al. | Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells. | 2001 | Am. J. Pathol. | pmid:11485917 |
| Takashima T et al. | PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity. | 2001 | Int. J. Oncol. | pmid:11494023 |
| Rovin BH et al. | Cyclopentenone prostaglandins inhibit cytokine-induced nf-kappab activation and chemokine production by human mesangial cells. | 2001 | J. Am. Soc. Nephrol. | pmid:11461938 |
| Cernuda-Morollón E et al. | 15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit. | 2001 | J. Biol. Chem. | pmid:11466314 |
| Boyault S et al. | 15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways. | 2001 | FEBS Lett. | pmid:11457450 |
| Clay CE et al. | Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells. | 2001 | J. Investig. Med. | pmid:11523697 |
| Hunter JG et al. | Peroxisome proliferator-activated receptor gamma ligands differentially modulate muscle cell differentiation and MyoD gene expression via peroxisome proliferator-activated receptor gamma -dependent and -independent pathways. | 2001 | J. Biol. Chem. | pmid:11477074 |