Yuan J et al. |
M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway. |
2017 |
Oncotarget |
pmid:28423639
|
Tang Q et al. |
Effect of 15-Deoxy-Δ12,14-prostaglandin J2Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model. |
2017 |
Chin. Med. J. |
pmid:28139520
|
Muhammad SN et al. |
15d-PGJ2 Induces Apoptosis of MCF-7 and MDA-MB-231 Cells via Increased Intracellular Calcium and Activation of Caspases, Independent of ERα and ERβ. |
2016 |
Asian Pac. J. Cancer Prev. |
pmid:27509924
|
Tsujimoto S et al. |
Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ. |
2016 |
Int. J. Mol. Med. |
pmid:27431935
|
Abbasi S et al. |
Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion. |
2016 |
Int J Nanomedicine |
pmid:27354798
|
Zhou J et al. |
Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats. |
2016 |
J. Cell. Mol. Med. |
pmid:27061967
|
Shibata T et al. |
Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. |
2016 |
Sci Rep |
pmid:26879669
|
Koyani CN et al. |
Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death. |
2016 |
Biochem. Pharmacol. |
pmid:26801686
|
Flores JJ et al. |
PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats. |
2016 |
Neurobiol. Dis. |
pmid:26739391
|
Nelson SM et al. |
Selenoprotein Expression in Macrophages Is Critical for Optimal Clearance of Parasitic Helminth Nippostrongylus brasiliensis. |
2016 |
J. Biol. Chem. |
pmid:26644468
|
Martinez-Cengotitabengoa M et al. |
BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. |
2016 |
Schizophr Bull |
pmid:26130821
|
Vishwakarma P et al. |
15d-Prostaglandin J2 induced reactive oxygen species-mediated apoptosis during experimental visceral leishmaniasis. |
2016 |
J. Mol. Med. |
pmid:26830627
|
Carregaro V et al. |
Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25-FOXP3+ Cells. |
2016 |
Mediators Inflamm. |
pmid:27872515
|
de Melo NF et al. |
15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation. |
2016 |
PLoS ONE |
pmid:27575486
|
Li WY et al. |
Effect of 15-Deoxy-â–³(12,14)-prostaglandin J2 on Expression of Macrophage Migration Inhibitory Factor in Mouse Monocyte/macrophage Cell Line J774A.1. |
2016 |
Zhongguo Yi Xue Ke Xue Yuan Xue Bao |
pmid:27544994
|
Kim HJ et al. |
ROSics: chemistry and proteomics of cysteine modifications in redox biology. |
2015 Mar-Apr |
Mass Spectrom Rev |
pmid:24916017
|
Huang L et al. |
15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model. |
2015 |
Biomed Res Int |
pmid:26844229
|
Li P et al. |
[Effect of peroxisome proliferator-activated receptor-γ on endothelial cells oxidative stress induced by Porphyromonas gingivalis]. |
2015 |
Beijing Da Xue Xue Bao |
pmid:26679661
|
Li XY et al. |
15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation. |
2015 |
Genet. Mol. Res. |
pmid:26535717
|
Xu X et al. |
Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism. |
2015 |
Cell. Physiol. Biochem. |
pmid:26279448
|
Jeon KI et al. |
Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts. |
2015 |
Exp. Eye Res. |
pmid:26142957
|
Guan PP et al. |
The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage. |
2015 |
Sci Rep |
pmid:25992485
|
Mirza RE et al. |
Macrophage PPARγ and impaired wound healing in type 2 diabetes. |
2015 |
J. Pathol. |
pmid:25875529
|
Gao D et al. |
Rosiglitzone suppresses angiotensin II-induced production of KLF5 and cell proliferation in rat vascular smooth muscle cells. |
2015 |
PLoS ONE |
pmid:25874449
|
Maier NK et al. |
The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. |
2015 |
J. Immunol. |
pmid:25681332
|
Wall SB et al. |
Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. |
2015 |
Redox Biol |
pmid:25677088
|
Hosoi T et al. |
Possible involvement of 15-deoxy-Δ(12,14) -prostaglandin J2 in the development of leptin resistance. |
2015 |
J. Neurochem. |
pmid:25662180
|
Meng Y et al. |
Angiotensin II-induced Egr-1 expression is suppressed by peroxisome proliferator-activated receptor-γ ligand 15d-PGJ₂ in macrophages. |
2015 |
Cell. Physiol. Biochem. |
pmid:25591955
|
Penas F et al. |
Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice. |
2015 |
Biochim. Biophys. Acta |
pmid:25557389
|
Hyun J et al. |
Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. |
2015 |
J Innate Immun |
pmid:25171731
|
Fang M et al. |
Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. |
2015 |
Environ. Sci. Technol. |
pmid:26172262
|
Kim KR et al. |
15-deoxy-δ12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss. |
2015 |
PLoS ONE |
pmid:25859665
|
Korolczuk A et al. |
The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity. |
2014 |
J. Physiol. Pharmacol. |
pmid:25554991
|
Korbecki J et al. |
Cyclooxygenase pathways. |
2014 |
Acta Biochim. Pol. |
pmid:25343148
|
Savinainen JR et al. |
Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). |
2014 |
PLoS ONE |
pmid:25290914
|
Samikkannu T et al. |
Immunopathogenesis of HIV infection in cocaine users: role of arachidonic acid. |
2014 |
PLoS ONE |
pmid:25171226
|
Savinainen JR et al. |
Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL). |
2014 |
Mol. Pharmacol. |
pmid:25140003
|
Wasinger C et al. |
Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells. |
2014 |
Br. J. Pharmacol. |
pmid:25091578
|
Paakinaho V et al. |
Electrophilic lipid mediator 15-deoxy-Δ12,14-prostaglandin j2 modifies glucocorticoid signaling via receptor SUMOylation. |
2014 |
Mol. Cell. Biol. |
pmid:24980431
|
Mantel A et al. |
Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. |
2014 |
Exp. Dermatol. |
pmid:24917395
|
Tang J et al. |
Aspirin treatment improved mesenchymal stem cell immunomodulatory properties via the 15d-PGJ2/PPARγ/TGF-β1 pathway. |
2014 |
Stem Cells Dev. |
pmid:24730450
|
Liu C et al. |
15d-PGJâ‚‚ decreases PGEâ‚‚ synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter. |
2014 |
Biochem. Pharmacol. |
pmid:25108236
|
Koyani CN et al. |
15-deoxy-Δ¹²,¹â´-PGJâ‚‚ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis. |
2014 |
Int. J. Cardiol. |
pmid:24698234
|
Yen CC et al. |
Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. |
2014 |
Oncotarget |
pmid:24566468
|
Wang C et al. |
A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. |
2014 |
Nat. Methods |
pmid:24292485
|
Olsen KC et al. |
Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. |
2014 |
Am. J. Respir. Cell Mol. Biol. |
pmid:24175906
|
GarcÃa-Bueno B et al. |
Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. |
2014 |
Schizophr Bull |
pmid:23486748
|
Kumar AP et al. |
Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. |
2014 |
Antioxid. Redox Signal. |
pmid:23964924
|
Katsumata Y et al. |
Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2. |
2014 |
Hypertension |
pmid:24101662
|
Casali CI et al. |
Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells. |
2014 |
Biochem. Pharmacol. |
pmid:24915420
|
Tachi M et al. |
Mass spectrometric determination of prostanoids in rat hypothalamic paraventricular nucleus microdialysates. |
2014 |
Auton Neurosci |
pmid:24447364
|
Kurtz M et al. |
Peroxisome proliferator-activated receptor ligands regulate lipid content, metabolism, and composition in fetal lungs of diabetic rats. |
2014 |
J. Endocrinol. |
pmid:24389592
|
Jung WK et al. |
The 15-deoxy-δ12,14-prostaglandin J2 inhibits LPS‑stimulated inflammation via enhancement of the platelet‑activating factor acetylhydrolase activity in human retinal pigment epithelial cells. |
2014 |
Int. J. Mol. Med. |
pmid:24337644
|
Chen S et al. |
15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) promotes apoptosis of HBx-positive liver cells. |
2014 |
Chem. Biol. Interact. |
pmid:24582817
|
Kang ES et al. |
15-Deoxy-Δ(12,14)-prostaglandin J2 prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells. |
2014 |
Free Radic. Res. |
pmid:24180671
|
Yin Y et al. |
PPARγ agonists regulate tobacco smoke-induced Toll like receptor 4 expression in alveolar macrophages. |
2014 |
Respir. Res. |
pmid:24612634
|
Heiss EH et al. |
Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata. |
2014 |
J. Nat. Prod. |
pmid:24476568
|
Lefils-Lacourtablaise J et al. |
The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. |
2013 |
PLoS ONE |
pmid:23734181
|
Welter H et al. |
Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. |
2013 |
Andrology |
pmid:23413143
|
Li H and Narahara H |
15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines. |
2013 |
Int. J. Mol. Med. |
pmid:23403520
|
Lu Y et al. |
15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells. |
2013 |
Nephron Exp. Nephrol. |
pmid:23887394
|
Marcone S and Fitzgerald DJ |
Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2. |
2013 |
Proteomics |
pmid:23606334
|
Fernandez-Bustamante A et al. |
Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. |
2013 |
Inflammation |
pmid:23616184
|
Hau CS et al. |
Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes. |
2013 |
J. Dermatol. Sci. |
pmid:23688403
|
Sánchez-Gómez FJ et al. |
Modulation of GSTP1-1 oligomerization by electrophilic inflammatory mediators and reactive drugs. |
2013 |
Inflamm Allergy Drug Targets |
pmid:23596995
|
Ramer R et al. |
COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells. |
2013 |
Mol. Cancer Ther. |
pmid:23220503
|
Haskew-Layton RE et al. |
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ. |
2013 |
J. Neurochem. |
pmid:23199167
|
Nakamura M et al. |
Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. |
2013 |
Biomed. Pharmacother. |
pmid:23206752
|
Nozaki Y et al. |
PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. |
2013 |
Med Mol Morphol |
pmid:23397546
|
Doyle MC et al. |
15-Deoxy-Δ(12,14)-prostaglandin J2 inhibits IL-13 production in T cells via an NF-κB-dependent mechanism. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:23333326
|
Xu F et al. |
Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. |
2013 |
PLoS ONE |
pmid:23372817
|
Sykes L et al. |
The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour. |
2013 |
Immunology |
pmid:23374103
|
Kaikkonen S et al. |
Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. |
2013 |
Mol. Endocrinol. |
pmid:23192983
|
Shashni B et al. |
Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology. |
2013 |
J Drug Target |
pmid:23130662
|
Abraki SB et al. |
Simultaneous inhibition of COX-2 and activation of PPAR-γ resulted in the same level and pattern of neuroprotection as they were targeted separately. |
2013 |
J. Mol. Neurosci. |
pmid:23132402
|
Xu X et al. |
Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation. |
2013 |
Steroids |
pmid:23707573
|
Buckner MM et al. |
15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium. |
2013 |
PLoS ONE |
pmid:23922794
|
Liu H et al. |
Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. |
2013 |
Neurotoxicology |
pmid:23973622
|
Bogacka I et al. |
The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. |
2013 |
Reprod Biol |
pmid:24287039
|
Davidson J et al. |
Eicosapentaenoic acid suppression of systemic inflammatory responses and inverse up-regulation of 15-deoxyΔ(12,14) prostaglandin J2 production. |
2013 |
Br. J. Pharmacol. |
pmid:23586396
|
Liu L et al. |
Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. |
2013 |
PLoS ONE |
pmid:24023668
|
Sharvit E et al. |
Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists. |
2013 |
PLoS ONE |
pmid:24098526
|
Kuriyan AE et al. |
Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. |
2013 |
Invest. Ophthalmol. Vis. Sci. |
pmid:24135759
|
Tan BS et al. |
6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). |
2013 |
Cancer Lett. |
pmid:23612072
|
Yaacob NS et al. |
Influence of 17β-estradiol on 15-deoxy-δ12,14 prostaglandin J2 -induced apoptosis in MCF-7 and MDA-MB-231 cells. |
2013 |
Asian Pac. J. Cancer Prev. |
pmid:24377602
|
Zerani M et al. |
Evidence for a luteotropic role of peroxisome proliferator-activated receptor gamma: expression and in vitro effects on enzymatic and hormonal activities in corpora lutea of pseudopregnant rabbits. |
2013 |
Biol. Reprod. |
pmid:23365414
|
Napimoga MH et al. |
Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner. |
2013 |
Int. Immunopharmacol. |
pmid:23597428
|
Ramer R et al. |
Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. |
2013 |
J. Lipid Res. |
pmid:23943857
|
Iida K et al. |
Sodium dodecyl sulfate and sodium dodecyl benzenesulfonate are ligands for peroxisome proliferator-activated receptor γ. |
2013 |
J Toxicol Sci |
pmid:24025786
|
Kattamuri PV et al. |
Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity. |
2013 |
Life Sci. |
pmid:22820546
|
Sykes L et al. |
Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes. |
2012 |
PLoS ONE |
pmid:23226366
|
Hossain MS et al. |
Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids. |
2012 |
Exp. Cell Res. |
pmid:22100987
|
Paulitschke V et al. |
Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. |
2012 |
PLoS ONE |
pmid:23049949
|
Weng Y et al. |
Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. |
2012 |
Mol Pain |
pmid:23013719
|
Miyawaki T et al. |
Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. |
2012 |
Immunopharmacol Immunotoxicol |
pmid:21854184
|
Kanakasabai S et al. |
PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. |
2012 |
PLoS ONE |
pmid:23185633
|
Springstead JR et al. |
Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function. |
2012 |
J. Lipid Res. |
pmid:22550136
|
He S et al. |
Identification, organ expression and ligand-dependent expression levels of peroxisome proliferator activated receptors in grass carp (Ctenopharyngodon idella). |
2012 |
Comp. Biochem. Physiol. C Toxicol. Pharmacol. |
pmid:22079418
|
Clemente-Napimoga JT et al. |
15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. |
2012 |
Life Sci. |
pmid:22564409
|
Napimoga MH et al. |
Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. |
2012 |
J. Immunol. |
pmid:22706081
|