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PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. |
2004 |
Br. J. Pharmacol. |
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Ray DM et al. |
Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. |
2004 |
Clin. Immunol. |
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Abdelrahman M et al. |
The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. |
2004 |
Shock |
pmid:15545828
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The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. |
2004 |
Biochem. Pharmacol. |
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Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1. |
2004 |
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Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. |
2004 |
J. Neuroimmunol. |
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Cheng S et al. |
Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. |
2004 |
J. Biol. Chem. |
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15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. |
2004 |
J. Biol. Chem. |
pmid:15024026
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Hashimoto K et al. |
Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. |
2004 |
Pancreas |
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15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. |
2004 |
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Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. |
2004 |
Mol. Cancer Ther. |
pmid:15486192
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Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. |
2004 |
Chem. Res. Toxicol. |
pmid:15487891
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Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. |
2004 |
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Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. |
2004 |
Anticancer Drugs |
pmid:15514564
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The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. |
2004 |
J. Immunol. |
pmid:15470065
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Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. |
2004 |
Biochem. Soc. Trans. |
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15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. |
2004 |
J. Immunol. |
pmid:15187150
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Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells. |
2004 |
Kidney Int. |
pmid:14871400
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PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. |
2004 |
Kidney Int. |
pmid:14871416
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Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. |
2004 |
Cancer Res. |
pmid:14871855
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Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. |
2004 |
Am. J. Respir. Crit. Care Med. |
pmid:14563653
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Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. |
2004 |
Biochem. Biophys. Res. Commun. |
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15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:15369766
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Schlezinger JJ et al. |
Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. |
2004 |
J. Immunol. |
pmid:15322177
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Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists. |
2004 |
Kidney Int. |
pmid:15149321
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Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. |
2004 |
Blood |
pmid:15130939
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Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin. |
2004 |
Crit. Care Med. |
pmid:15090969
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PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase. |
2004 |
Circ. Res. |
pmid:15117825
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Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells. |
2003 Feb-Mar |
Placenta |
pmid:12566244
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Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling. |
2003 |
J. Immunol. |
pmid:14607914
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Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. |
2003 |
J. Immunol. |
pmid:12847270
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Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. |
2003 |
J. Pharmacol. Exp. Ther. |
pmid:12649303
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Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. |
2003 |
Cancer Res. |
pmid:12839938
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Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2. |
2003 |
Exp. Mol. Med. |
pmid:14508070
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Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone. |
2003 |
J. Dent. Res. |
pmid:14514760
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Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor. |
2003 |
Mol. Pharmacol. |
pmid:14573767
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Collin M and Thiemermann C |
The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock. |
2003 |
Eur. J. Pharmacol. |
pmid:12969773
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Cuzzocrea S et al. |
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. |
2003 |
Br. J. Pharmacol. |
pmid:12970094
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Powell WS |
15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product? |
2003 |
J. Clin. Invest. |
pmid:12975467
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15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line. |
2003 |
World J. Gastroenterol. |
pmid:14562367
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Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. |
2003 |
J. Clin. Invest. |
pmid:12975479
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Kanbe E et al. |
DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand. |
2003 |
Exp. Hematol. |
pmid:12691917
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Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction. |
2003 |
FASEB J. |
pmid:12692090
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Garg TK and Chang JY |
Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. |
2003 |
BMC Ophthalmol |
pmid:12659653
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Chung YW et al. |
[Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells]. |
2003 |
Korean J Gastroenterol |
pmid:14532729
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Worley JR et al. |
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. |
2003 |
J. Biol. Chem. |
pmid:14534304
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Castaño E and Gil J |
15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. |
2003 |
J. Cell. Physiol. |
pmid:12704651
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Faveeuw C et al. |
Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. |
2003 |
Eur. J. Immunol. |
pmid:12672054
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Expression and molecular pharmacology of the mouse CRTH2 receptor. |
2003 |
J. Pharmacol. Exp. Ther. |
pmid:12721327
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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12684535
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