| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tian Y et al. | Differential modulation of L-type calcium channel subunits by oleate. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18430963 |
| Carpentier AC et al. | On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humans. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15972273 |
| Jacobs KA et al. | Endurance training has little effect on active muscle free fatty acid, lipoprotein cholesterol, or triglyceride net balances. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16684856 |
| Steinberg GR et al. | Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12067860 |
| Mittendorfer B et al. | Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12067843 |
| Djurhuus CB et al. | Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12067858 |
| Bergman BC et al. | Myocardial FFA metabolism during rest and atrial pacing in humans. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19066320 |
| Chabowski A et al. | Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15166001 |
| Tucker MZ and Turcotte LP | Impaired fatty acid oxidation in muscle of aging rats perfused under basal conditions. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11934676 |
| Parton LE et al. | Impact of PPARgamma overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15126236 |
| Kim JY et al. | Lipid oxidation is reduced in obese human skeletal muscle. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:11052958 |
| Wilmsen HM et al. | Thiazolidinediones upregulate impaired fatty acid uptake in skeletal muscle of type 2 diabetic subjects. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12700163 |
| Vaidyanathan V et al. | Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22761159 |
| Steinberg GR et al. | Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11832362 |
| Turpin SM et al. | Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16849630 |
| Belke DD et al. | Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:11052966 |
| Noland RC et al. | Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17638705 |
| Wei Y et al. | Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16492686 |
| Lupi R et al. | Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:14625208 |
| Hodson L et al. | Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20628024 |
| Alkhateeb H et al. | Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17550999 |
| Luiken JJ et al. | Insulin induces the translocation of the fatty acid transporter FAT/CD36 to the plasma membrane. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11788383 |
| O'Donnell JM et al. | Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234271 |
| Kump DS et al. | Increased mitochondrial glycerol-3-phosphate acyltransferase protein and enzyme activity in rat epididymal fat upon cessation of wheel running. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234267 |
| Peterson JM et al. | Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18840766 |
| Cha BS et al. | Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARgamma agonists. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15727952 |
| Samokhvalov V et al. | Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18840759 |
| Hong J et al. | Stevioside counteracts the alpha-cell hypersecretion caused by long-term palmitate exposure. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16204336 |
| Han XX et al. | Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese Zucker rat muscle. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17519284 |
| Nellemann B et al. | Kinetics and utilization of lipid sources during acute exercise and acipimox. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24895285 |
| Cheng H et al. | Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12684222 |
| Raney MA et al. | AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15547141 |
| Kanaley JA et al. | Hyperinsulinemia and skeletal muscle fatty acid trafficking. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23820622 |
| Qi D et al. | Fatty acids induce amylin expression and secretion by pancreatic beta-cells. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:19843871 |
| Qi D et al. | Altered cardiac fatty acid composition and utilization following dexamethasone-induced insulin resistance. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16608885 |
| Kim JY et al. | Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11934665 |
| Dyck DJ et al. | Endurance training increases FFA oxidation and reduces triacylglycerol utilization in contracting rat soleus. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10780932 |
| Lai E et al. | Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18198352 |
| Lessard SJ et al. | Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16118254 |
| Reeds DN et al. | Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16118251 |
| Yee AJ and Turcotte LP | Insulin fails to alter plasma LCFA metabolism in muscle perfused at similar glucose uptake. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12067845 |
| Alkhateeb H et al. | Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipids. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19724017 |
| Mittendorfer B et al. | Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:14625204 |
| Montell E et al. | DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11158925 |
| Hodson L et al. | Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18940935 |
| Dyck DJ et al. | Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11500316 |
| Wang W et al. | Effect of nicotinic acid administration on hepatic very low density lipoprotein-triglyceride production. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11171611 |
| Holloway GP et al. | Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17311893 |
| Mardy K et al. | Chylomicron metabolism by the isolated perfused mouse heart. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11440913 |
| Ussher JR et al. | Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19625676 |
| Lau R et al. | Stimulatory effects of leptin and muscle contraction on fatty acid metabolism are not additive. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11404229 |
| Liu PY et al. | Genetic, hormonal, and metabolomic influences on social behavior and sex preference of XXY mice. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20570823 |
| Das SK et al. | Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18544642 |
| Collier CA et al. | Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16478780 |
| Doliba NM et al. | Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20606076 |
| Peter A et al. | Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18523127 |
| Dasu MR and Jialal I | Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:20959532 |
| Baldwin AC et al. | A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22436701 |
| Harney JA and Rodgers RL | Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18492769 |
| Tucker MZ and Turcotte LP | Aging is associated with elevated muscle triglyceride content and increased insulin-stimulated fatty acid uptake. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12783776 |
| Sebastián D et al. | CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17062841 |
| Turner SM et al. | Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17164440 |
| Watt MJ et al. | Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12759219 |
| Luiken JJ et al. | Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11551846 |
| Liu YJ et al. | Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12709398 |
| Jin J et al. | Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23921144 |
| Hiscock N et al. | Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15741245 |
| Belke DD et al. | Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11171596 |
| Krag MB et al. | Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17132823 |
| Holloway GP et al. | PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18349111 |
| Faleck DM et al. | Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20484013 |
| Macfarlane DP et al. | Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21119028 |
| Hulver MW et al. | Skeletal muscle lipid metabolism with obesity. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12626325 |
| Takahashi K et al. | JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. | 2008 | Am. J. Physiol. Endocrinol. Metab. | pmid:18303122 |
| Carpentier AC et al. | Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humans. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17062840 |
| Carroll R et al. | Metabolic effects of insulin on cardiomyocytes from control and diabetic db/db mouse hearts. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15632103 |
| Bézaire V et al. | Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11595653 |
| Guo W et al. | Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17519282 |
| Varma V et al. | Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19336660 |
| Posey KA et al. | Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19116375 |
| Pillon NJ et al. | Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis. | 2015 | Am. J. Physiol. Endocrinol. Metab. | pmid:25944880 |
| Atkinson LL et al. | Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12464581 |
| Turcotte LP et al. | High carbohydrate availability increases LCFA uptake and decreases LCFA oxidation in perfused muscle. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11739099 |
| Choi SJ et al. | Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20354158 |
| Clerk LH et al. | Nonnutritive flow impairs uptake of fatty acid by white muscles of the perfused rat hindlimb. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12453824 |
| Bassilian S et al. | Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11832351 |
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| Hung DY et al. | Reduced hepatic extraction of palmitate in steatosis correlated to lower level of liver fatty acid binding protein. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15345470 |
| Cazanave SC et al. | CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20430872 |
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palmitic acid
palmitic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Apoptosis, Synthesis, inhibitors, Oxidation and targeting. Palmitic acid often locates in Extracellular, Muscle, Protoplasm, Body tissue and Blood. The related lipids are Palmitates, Sodium Palmitate and saturated fat.
Cross Reference
Introduction
To understand associated biological information of palmitic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with palmitic acid?
There are no associated biomedical information in the current reference collection.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with palmitic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with palmitic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with palmitic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with palmitic acid?
Related references are published most in these journals:
- Arch. Dis. Child. Fetal Neonatal Ed. (1)
- Cancer Epidemiol. Biomarkers Prev. (1)
- Eur. J. Endocrinol. (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with palmitic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with palmitic acid?
There are no associated biomedical information in the current reference collection.