| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
baicalein
baicalein is a lipid of Polyketides (PK) class. Baicalein is associated with abnormalities such as Neurodegenerative Disorders, Fibrillation, Hypertensive disease, Aortic coarctation and Coronary Occlusion. The involved functions are known as Anabolism, Polymerization, Process, inhibitors and Pathogenesis. Baicalein often locates in Membrane, Lipid Bilayers, soluble, Cell-Free System and Protoplasm. The associated genes with baicalein are P4HTM gene, BIRC5 gene, TSPO gene, SHOC2 gene and XIAP gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, iodoresiniferatoxin, Lipopolysaccharides and 17-octadecynoic acid. The related experimental models are Knock-out, Mouse Model and Parkinsonism, Experimental.
Cross Reference
Introduction
To understand associated biological information of baicalein, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with baicalein?
baicalein is suspected in Ischemia, Fibrillation, Hypertensive disease, Coronary Occlusion, Morphologically altered structure, Transient ischemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with baicalein
PubChem Associated disorders and diseases
What pathways are associated with baicalein
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with baicalein?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with baicalein?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with baicalein?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with baicalein?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with baicalein?
Mouse Model
Mouse Model are used in the study 'Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression.' (Gao J et al., 2011) and Mouse Model are used in the study 'Baicalein and 12/15-lipoxygenase in the ischemic brain.' (van Leyen K et al., 2006).
Knock-out
Knock-out are used in the study 'Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia.' (Jin G et al., 2008).
Parkinsonism, Experimental
Parkinsonism, Experimental are used in the study 'Cu(II) promotes amyloid pore formation.' (Zhang H et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with baicalein
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li Y et al. | The effects of baicalein or baicalin on the colloidal stability of ZnO nanoparticles (NPs) and toxicity of NPs to Caco-2 cells. | 2018 | Toxicol. Mech. Methods | pmid:28868948 |
| Zhao Q et al. | Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis. | 2018 | Mol Plant | pmid:28842248 |
| Dymarska M et al. | Glycosylation of 3-Hydroxyflavone, 3-Methoxyflavone, Quercetin and Baicalein in Fungal Cultures of the Genus . | 2018 | Molecules | pmid:30262733 |
| Omwenga EO et al. | Chitosan nanoencapsulation of flavonoids enhances their quorum sensing and biofilm formation inhibitory activities against an E.coli Top 10 biosensor. | 2018 | Colloids Surf B Biointerfaces | pmid:29413589 |
| Chen C et al. | Baicalein protects renal tubular epithelial cells againsthypoxia-reoxygenation injury. | 2018 | Ren Fail | pmid:30384801 |
| Min W et al. | Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice. | 2018 | Cell. Physiol. Biochem. | pmid:30308480 |
| Zhang R et al. | Radix Scutellariae Attenuates CUMS-Induced Depressive-Like Behavior by Promoting Neurogenesis via cAMP/PKA Pathway. | 2018 | Neurochem. Res. | pmid:30259256 |
| Chen Z et al. | Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin. | 2018 | Cell. Physiol. Biochem. | pmid:30244250 |
| Wu SC et al. | Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response. | 2018 | Phytomedicine | pmid:30195877 |
| Lin R et al. | Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats. | 2018 | Drug Des Devel Ther | pmid:30087551 |
| Ma L et al. | Baicalein Protects Rats with Diabetic Cardiomyopathy Against Oxidative Stress and Inflammation Injury via Phosphatidylinositol 3-Kinase (PI3K)/AKT Pathway. | 2018 | Med. Sci. Monit. | pmid:30070262 |
| He K et al. | Baicalein and Ly294002 induces liver cancer cells apoptosis via regulating phosphatidyl inositol 3-kinase/Akt signaling pathway. | 2018 | J Cancer Res Ther | pmid:29970718 |
| Guo N et al. | Integrated study of the mechanism of tyrosinase inhibition by baicalein using kinetic, multispectroscopic and computational simulation analyses. | 2018 | Int. J. Biol. Macromol. | pmid:29908273 |
| Zhang J et al. | Baicalein inhibits osteosarcoma cell proliferation and invasion through the miR‑183/Ezrin pathway. | 2018 | Mol Med Rep | pmid:29845278 |
| Xu J et al. | Therapeutic effect of the natural compounds baicalein and baicalin on autoimmune diseases. | 2018 | Mol Med Rep | pmid:29845272 |
| Su MQ et al. | Baicalein induces the apoptosis of HCT116Â human colon cancer cells via the upregulation of DEPP/Gadd45a and activation of MAPKs. | 2018 | Int. J. Oncol. | pmid:29749481 |
| Kim YJ et al. | Anti-Inflammatory Effect of Baicalein on Polyinosinicâ»Polycytidylic Acid-Induced RAW 264.7 Mouse Macrophages. | 2018 | Viruses | pmid:29701676 |
| Kolouchová I et al. | Resveratrol, pterostilbene, and baicalein: plant-derived anti-biofilm agents. | 2018 | Folia Microbiol. (Praha) | pmid:28971316 |
| Song L et al. | Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway. | 2018 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:29697746 |
| Terabayashi T et al. | Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumor microenvironment. | 2018 | Genes Cells | pmid:29667279 |
| Shi L et al. | Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC. | 2018 | Biochem. Pharmacol. | pmid:29338970 |
| Yu X et al. | Baicalein inhibits cervical cancer progression via downregulating long noncoding RNA BDLNR and its downstream PI3K/Akt pathway. | 2018 | Int. J. Biochem. Cell Biol. | pmid:29175387 |
| Shi R et al. | Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats. | 2018 | Pulm Pharmacol Ther | pmid:29133079 |
| Wu X et al. | Baicalein Inhibits the Proliferation of Cervical Cancer Cells Through the GSK3β-Dependent Pathway. | 2018 | Oncol. Res. | pmid:28835320 |
| Yu X et al. | Long noncoding RNA NKILA enhances the anti-cancer effects of baicalein in hepatocellular carcinoma via the regulation of NF-κB signaling. | 2018 | Chem. Biol. Interact. | pmid:29481769 |
| Su H et al. | Endogenous salicylic acid shows different correlation with baicalin and baicalein in the medicinal plant Scutellaria baicalensis Georgi subjected to stress and exogenous salicylic acid. | 2018 | PLoS ONE | pmid:29438420 |
| Zhang T et al. | Orthogonal Array composite design to study and optimize antioxidant combinations in the prevention of UVB-induced HSF damage. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29258053 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Chassagne F et al. | A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. | 2018 | Fitoterapia | pmid:29477305 |
| Chen Y et al. | Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-κB and MAPK pathways. | 2018 | Braz. J. Med. Biol. Res. | pmid:30088539 |
| Shi R et al. | Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition. | 2018 | Life Sci. | pmid:29969608 |
| Li W et al. | A strategy to improve the oral availability of baicalein: The baicalein-theophylline cocrystal. | 2018 | Fitoterapia | pmid:29936192 |
| Hsu WL et al. | Baicalein Ameliorates Pulmonary Arterial Hypertension Caused by Monocrotaline through Downregulation of ET-1 and ETR in Pneumonectomized Rats. | 2018 | Am. J. Chin. Med. | pmid:29737212 |
| Liu J et al. | Baicalein Enhances Migration and Invasion of Extravillous Trophoblasts via Activation of the NF-κB Pathway. | 2018 | Med. Sci. Monit. | pmid:29735973 |
| Liu XP et al. | Baicalein Inhibits Proliferation of Myeloma U266 Cells by Downregulating IKZF1 and IKZF3. | 2018 | Med. Sci. Monit. | pmid:29729093 |
| Zhang Y et al. | Baicalein inhibits growth of Epstein-Barr virus-positive nasopharyngeal carcinoma by repressing the activity of EBNA1 Q-promoter. | 2018 | Biomed. Pharmacother. | pmid:29710517 |
| Tian X et al. | Baicalein Accelerates Tendon-Bone Healing via Activation of Wnt/-Catenin Signaling Pathway in Rats. | 2018 | Biomed Res Int | pmid:29693006 |
| Su G et al. | Baicalein suppresses non small cell lung cancer cell proliferation, invasion and Notch signaling pathway. | 2018 | Cancer Biomark | pmid:29614624 |
| Shao Z et al. | Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation. | 2018 | Int J Mol Sci | pmid:29587364 |
| Li J et al. | Baicalein sensitizes hepatocellular carcinoma cells to 5-FU and Epirubicin by activating apoptosis and ameliorating P-glycoprotein activity. | 2018 | Biomed. Pharmacother. | pmid:29571250 |
| Wang X et al. | Phosphorus doped graphitic carbon nitride nanosheets as fluorescence probe for the detection of baicalein. | 2018 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:29501001 |
| Yu X et al. | Baicalein induces cervical cancer apoptosis through the NF-κB signaling pathway. | 2018 | Mol Med Rep | pmid:29393414 |
| Li Y et al. | Triggering of Autophagy by Baicalein in Response to Apoptosis after Spinal Cord Injury: Possible Involvement of the PI3K Activation. | 2018 | Biol. Pharm. Bull. | pmid:29367475 |
| Li J et al. | Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells. | 2018 | World J. Gastroenterol. | pmid:29358880 |
| Wang SX et al. | Liposome‑delivered baicalein induction of myeloid leukemia K562 cell death via reactive oxygen species generation. | 2018 | Mol Med Rep | pmid:29328378 |
| Wan CX et al. | Baicalein protects against endothelial cell injury by inhibiting the TLR4/NF‑κB signaling pathway. | 2018 | Mol Med Rep | pmid:29257294 |
| Yin H et al. | Baicalein improves liver inflammation in diabetic db/db mice by regulating HMGB1/TLR4/NF-κB signaling pathway. | 2018 | Int. Immunopharmacol. | pmid:29223854 |
| Aliakbari F et al. | Formulation and anti-neurotoxic activity of baicalein-incorporating neutral nanoliposome. | 2018 | Colloids Surf B Biointerfaces | pmid:29149763 |
| Zhang Y et al. | The Influence of Compatibility of Rhubarb and Radix Scutellariae on the Pharmacokinetics of Anthraquinones and Flavonoids in Rat Plasma. | 2018 | Eur J Drug Metab Pharmacokinet | pmid:29134502 |
| Ha TK et al. | Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity. | 2018 | Biotechnol J | pmid:29125225 |