| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Oroxylin A
Oroxylin A is a lipid of Polyketides (PK) class.
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There are no associated biomedical information in the current reference collection.
Current reference collection contains 747 references associated with Oroxylin A in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Oroxylin A
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All references with Oroxylin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Chen Y et al. | Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. | 2000 | Biochem. Pharmacol. | pmid:10751555 |
| Ma SC et al. | Antiviral Chinese medicinal herbs against respiratory syncytial virus. | 2002 | J Ethnopharmacol | pmid:11801383 |
| Huen MS et al. | 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. | 2003 | Biochem. Pharmacol. | pmid:12818372 |
| Li HB and Chen F | Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:15941045 |
| Suresh Babu K et al. | Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16046127 |
| Pomilio AB et al. | Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana. | 1992 | J Ethnopharmacol | pmid:1608273 |
| Kim YH et al. | Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16893689 |
| Huang WH et al. | Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. | 2006 | Biosci. Biotechnol. Biochem. | pmid:17031041 |
| Hu Y et al. | Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17069758 |
| Kim DH et al. | Effect of the flavonoid, oroxylin A, on transient cerebral hypoperfusion-induced memory impairment in mice. | 2006 | Pharmacol. Biochem. Behav. | pmid:17174385 |
| Kim DH et al. | The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice. | 2007 | Neurobiol Learn Mem | pmid:17196405 |
| Kim YH et al. | Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. | 2007 | Arch. Pharm. Res. | pmid:17366750 |
| Chen JJ et al. | New dihydrochalcones and anti-platelet aggregation constituents from the leaves of Muntingia calabura. | 2007 | Planta Med. | pmid:17516329 |
| Hattori T et al. | Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition. | 2007 | Clin. Exp. Nephrol. | pmid:18085387 |
| Hari Babu T et al. | Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18255289 |
| Kim DH et al. | The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. | 2008 | Neuropharmacology | pmid:18620712 |
| Yang Y et al. | Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells. | 2008 | J. Pharm. Pharmacol. | pmid:18957166 |
| Sun Y et al. | Oroxylin A suppresses invasion through down-regulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells. | 2009 | Eur. J. Pharmacol. | pmid:19100732 |
| Li HN et al. | Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. | 2009 | Toxicology | pmid:19135124 |
| Shih HC et al. | In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. | 2009 | J. Biomed. Sci. | pmid:19272127 |
| Liu W et al. | MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. | 2009 | Cancer Lett. | pmid:19473757 |
| Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
| Zhao L et al. | Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. | 2010 | Cancer Chemother. Pharmacol. | pmid:19585117 |
| Mu R et al. | Involvement of p53 in oroxylin A-induced apoptosis in cancer cells. | 2009 | Mol. Carcinog. | pmid:19626645 |
| Go WJ et al. | Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. | 2009 | J. Nat. Prod. | pmid:19739602 |
| Zhou XQ et al. | [Flavonoids from Scutellaria baicalensis and their bioactivities]. | 2009 | Beijing Da Xue Xue Bao | pmid:19829679 |
| Gao Y et al. | Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylation. | 2010 | J. Cancer Res. Clin. Oncol. | pmid:19888602 |
| Marques MR et al. | Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers. | 2010 | Fitoterapia | pmid:20117183 |
| Zhou Q et al. | Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. | 2010 | Pharm. Res. | pmid:20411407 |
| Trinh HT et al. | Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice. | 2010 | Acta Pharmacol. Sin. | pmid:20453872 |
| Lee S et al. | Oroxylin A, a flavonoid, stimulates adult neurogenesis in the hippocampal dentate gyrus region of mice. | 2010 | Neurochem. Res. | pmid:20680459 |
| SASTRI VD and SESHADRI TR | Constitution of oroxylin-A. | 1946 | Curr. Sci. | pmid:20999086 |
| Li C et al. | Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. | 2011 | J Pharm Biomed Anal | pmid:21051171 |
| Kumar GS et al. | Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors. | 2010 | J Asian Nat Prod Res | pmid:21061220 |
| Jeon SJ et al. | Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture. | 2011 | Neurosci. Res. | pmid:21145362 |
| Yang HY et al. | Oroxylin A reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-κB signaling pathway. | 2012 | Mol. Carcinog. | pmid:21557331 |
| Kim DH et al. | 4'-bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-κB signaling pathway in RAW 264.7 macrophages. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22101131 |
| Lu QY et al. | Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. | 2012 | Pancreas | pmid:22158070 |
| Li C et al. | Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. | 2012 | AAPS J | pmid:22167378 |
| Fu W et al. | Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22196122 |
| Lu Z et al. | Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway. | 2012 | Toxicol. Lett. | pmid:22245252 |
| Zhu B et al. | Oroxylin A reverses CAM-DR of HepG2 cells by suppressing Integrinβ1 and its related pathway. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22310179 |
| Pham TA et al. | Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22366656 |
| Hu R et al. | The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors. | 2012 | Anticancer Drugs | pmid:22526619 |
| Zou M et al. | Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. | 2012 | Cell. Signal. | pmid:22560876 |
| Ha J et al. | Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway. | 2012 | Biochem. Cell Biol. | pmid:22607196 |
| Xu M et al. | Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cells. | 2012 | Toxicol. Lett. | pmid:22609744 |
| Tong L et al. | Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. | 2012 | J Pharm Biomed Anal | pmid:22703838 |
| Wang H et al. | [Vasodilator effect of oroxylin A on thoracic aorta isolated from rats]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22883404 |
| Yao J et al. | Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling. | 2014 | Mol. Carcinog. | pmid:22949302 |
| Tseng TL et al. | Oroxylin-A rescues LPS-induced acute lung injury via regulation of NF-κB signaling pathway in rodents. | 2012 | PLoS ONE | pmid:23071799 |
| Guo H et al. | [Preparation of flavonoid reference standards from Scutellariae Radix under the guidance of high performance liquid chromatography-mass spectrometry analysis]. | 2012 | Se Pu | pmid:23189664 |
| Liu PW et al. | STAT1 mediates oroxylin a inhibition of iNOS and pro-inflammatory cytokines expression in microglial BV-2 cells. | 2012 | PLoS ONE | pmid:23236370 |
| Song X et al. | Oroxylin A, a classical natural product, shows a novel inhibitory effect on angiogenesis induced by lipopolysaccharide. | 2012 | Pharmacol Rep | pmid:23238475 |
| Dong J et al. | Oroxylin A inhibits hemolysis via hindering the self-assembly of α-hemolysin heptameric transmembrane pore. | 2013 | PLoS Comput. Biol. | pmid:23349625 |
| Yoon SY et al. | Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro. | 2013 | Arch. Pharm. Res. | pmid:23371806 |
| Zhu L et al. | Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest. | 2013 | Toxicol. Lett. | pmid:23470866 |
| Wei L et al. | Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II. | 2013 | Biochim. Biophys. Acta | pmid:23500080 |
| Liu X et al. | The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice. | 2013 | Arch. Pharm. Res. | pmid:23543630 |
| Wei L et al. | Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma. | 2013 | Cell Death Dis | pmid:23598413 |
| Dai Q et al. | Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23612020 |
| dela Peña IC et al. | 5,7-Dihydroxy-6-methoxy-4'-phenoxyflavone, a derivative of oroxylin A improves attention-deficit/hyperactivity disorder (ADHD)-like behaviors in spontaneously hypertensive rats. | 2013 | Eur. J. Pharmacol. | pmid:23707903 |
| Yang X et al. | Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. | 2013 | Inflamm. Bowel Dis. | pmid:23823704 |
| Wang H et al. | An estrogen receptor dependent mechanism of Oroxylin A in the repression of inflammatory response. | 2013 | PLoS ONE | pmid:23922737 |
| Hui H et al. | Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα. | 2014 | Int. J. Cancer | pmid:23934681 |
| Zhu R et al. | Oroxylin A accelerates liver regeneration in CClâ‚„-induced acute liver injury mice. | 2013 | PLoS ONE | pmid:23951204 |
| Ku SK et al. | Antithrombotic activities of oroxylin A in vitro and in vivo. | 2014 | Arch. Pharm. Res. | pmid:23963976 |
| Li C et al. | Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. | 2014 | Pharm Biol | pmid:24102566 |
| Fong SY and Zuo Z | Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. | 2014 | Xenobiotica | pmid:24168065 |
| Ku SK et al. | Inhibitory effects of oroxylin A on endothelial protein C receptor shedding in vitro and in vivo. | 2014 | BMB Rep | pmid:24286327 |
| Qiu J et al. | Molecular modeling reveals the novel inhibition mechanism and binding mode of three natural compounds to staphylococcal α-hemolysin. | 2013 | PLoS ONE | pmid:24312202 |
| Cheng Y et al. | Oroxylin A inhibits hypoxia-induced invasion and migration of MCF-7 cells by suppressing the Notch pathway. | 2014 | Anticancer Drugs | pmid:24637576 |
| Li X et al. | Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway. | 2015 | Arch. Toxicol. | pmid:24671465 |
| Fong SY et al. | Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. | 2014 | J Pharm Biomed Anal | pmid:24803030 |
| Wang Y et al. | CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells. | 2014 | Biochem. Pharmacol. | pmid:24858801 |
| Hui H et al. | Oroxylin A inhibits ATRA-induced IL-6 expression involved in retinoic acid syndrome by down-regulating CHOP. | 2014 | Gene | pmid:25192658 |
| Zou M et al. | Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway. | 2015 | Mol. Carcinog. | pmid:25213258 |
| Kim DH et al. | Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice. | 2014 | Brain Res. Bull. | pmid:25218897 |
| Ye M et al. | Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation. | 2014 | Biochem. Cell Biol. | pmid:25247252 |
| Qiao C et al. | UCP2-related mitochondrial pathway participates in oroxylin A-induced apoptosis in human colon cancer cells. | 2015 | J. Cell. Physiol. | pmid:25251374 |
| Singh J and Kakkar P | Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells. | 2014 | Phytomedicine | pmid:25442284 |
| Huang H et al. | Protective effect of oroxylin A against lipopolysaccharide and/or D-galactosamine-induced acute liver injury in mice. | 2015 | J. Surg. Res. | pmid:25818981 |
| Wei L et al. | Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. | 2015 | Cell Death Dis | pmid:25855962 |
| Zhao K et al. | Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. | 2015 | J Hematol Oncol | pmid:25902914 |
| Dai Q et al. | Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. | 2016 | Mol. Carcinog. | pmid:26259145 |
| Tseng TL et al. | Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock. | 2016 | Br. J. Pharmacol. | pmid:26694894 |
| Wei L et al. | Oroxylin A inhibits invasion and migration through suppressing ERK/GSK-3β signaling in snail-expressing non-small-cell lung cancer cells. | 2016 | Mol. Carcinog. | pmid:26741501 |
| Zhou DG et al. | Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model. | 2016 | Inflammation | pmid:26895180 |
| Yang H et al. | Drug activity screening based on microsomes-hydrogel system in predicting metabolism induced antitumor effect of oroxylin A. | 2016 | Sci Rep | pmid:26905263 |
| Qiao C et al. | Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. | 2016 | Oncotarget | pmid:26958937 |
| Hui H et al. | Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27085528 |
| Huang L et al. | Application of a new method, orthogonal projection to latent structure (OPLS) combined with principal component analysis (PCA), to screening of prostaglandin E2 production inhibitory flavonoids in Scutellaria Root. | 2016 | J Nat Med | pmid:27164908 |
| Kwon BE et al. | Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. | 2016 | PLoS ONE | pmid:27195463 |
| Zhang YY et al. | Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase. | 2016 | FEBS Lett. | pmid:27432544 |
| Mangal P et al. | Screening of six Ayurvedic medicinal plants for anti-obesity potential: An investigation on bioactive constituents from Oroxylum indicum (L.) Kurz bark. | 2017 | J Ethnopharmacol | pmid:27469197 |
| Li W et al. | Oroxylin A reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12/CXCR7 axis in bone marrow microenvironment. | 2017 | Mol. Carcinog. | pmid:27533597 |
| Lu L et al. | Overview of Oroxylin A: A Promising Flavonoid Compound. | 2016 | Phytother Res | pmid:27539056 |
| Tan C et al. | Oroxylin a could be a Promising Radiosensitizer for Esophageal Squamous Cell Carcinoma by Inducing G2/M Arrest and Activating Apoptosis. | 2017 | Pathol. Oncol. Res. | pmid:27585443 |
| Wang YL et al. | Therapeutic potential of Oroxylin A in rheumatoid arthritis. | 2016 | Int. Immunopharmacol. | pmid:27643663 |