| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Oroxylin A
Oroxylin A is a lipid of Polyketides (PK) class.
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There are no associated biomedical information in the current reference collection.
Current reference collection contains 747 references associated with Oroxylin A in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Oroxylin A
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All references with Oroxylin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang Q et al. | Determination of oroxylin A and oroxylin A 7-O-d-glucuronide in HepG2 cell lysate and subcellular fractions with SPE-UPLC-MS/MS: Cellular pharmacokinetic study to indicate anti-cancer mechanisms. | 2018 | J Pharm Biomed Anal | pmid:29571134 |
| Chen W et al. | Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation. | 2018 | Int. Immunopharmacol. | pmid:29414645 |
| Jin H et al. | Oroxylin A inhibits ethanol-induced hepatocyte senescence via YAP pathway. | 2018 | Cell Prolif. | pmid:29318697 |
| Jin J et al. | Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs. | 2018 | Biomed. Pharmacother. | pmid:29091888 |
| Wu SC et al. | Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response. | 2018 | Phytomedicine | pmid:30195877 |
| Zhang C et al. | Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling. | 2018 | J. Cell. Biochem. | pmid:28857294 |
| Shimizu T et al. | Synergistic effect of baicalein, wogonin and oroxylin A mixture: multistep inhibition of the NF-κB signalling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids. | 2018 | J Nat Med | pmid:28921127 |
| Jin H et al. | Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha. | 2018 | Chem. Biol. Interact. | pmid:29476730 |
| Chassagne F et al. | A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. | 2018 | Fitoterapia | pmid:29477305 |
| Zhang R et al. | Catechol-O-Methyltransferase and UDP-Glucuronosyltransferases in the Metabolism of Baicalein in Different Species. | 2017 | Eur J Drug Metab Pharmacokinet | pmid:28536775 |
| Fong SYK et al. | Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. | 2017 | Mol. Pharm. | pmid:28426226 |
| Mangal P et al. | Screening of six Ayurvedic medicinal plants for anti-obesity potential: An investigation on bioactive constituents from Oroxylum indicum (L.) Kurz bark. | 2017 | J Ethnopharmacol | pmid:27469197 |
| Chen M et al. | Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. | 2017 | Biomed. Chromatogr. | pmid:28236316 |
| Han Q et al. | Oroxylin A inhibits HO-induced oxidative stress in PC12 cells. | 2017 | Nat. Prod. Res. | pmid:27820974 |
| Tan C et al. | Oroxylin a could be a Promising Radiosensitizer for Esophageal Squamous Cell Carcinoma by Inducing G2/M Arrest and Activating Apoptosis. | 2017 | Pathol. Oncol. Res. | pmid:27585443 |
| Li W et al. | Oroxylin A reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12/CXCR7 axis in bone marrow microenvironment. | 2017 | Mol. Carcinog. | pmid:27533597 |
| Lin SF et al. | Oroxylin A promotes retinal ganglion cell survival in a rat optic nerve crush model. | 2017 | PLoS ONE | pmid:28640893 |
| Wei L et al. | Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. | 2017 | Cell Death Dis | pmid:28726775 |
| Ni T et al. | Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism. | 2017 | Cell Death Dis | pmid:28594405 |
| Shen L et al. | Oroxylin A inhibits the generation of Tregs in non-small cell lung cancer. | 2017 | Oncotarget | pmid:28472762 |
| Fu X et al. | A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications. | 2017 | Chem. Commun. (Camb.) | pmid:28286894 |
| Yu H et al. | Enhancement of solubility and dissolution rate of baicalein, wogonin and oroxylin A extracted from Radix scutellariae. | 2017 | Int J Pharm | pmid:28642200 |
| Liu RX et al. | Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis. | 2017 | Chin J Nat Med | pmid:28284428 |
| Zhang YY et al. | Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase. | 2016 | FEBS Lett. | pmid:27432544 |
| Lu L et al. | Overview of Oroxylin A: A Promising Flavonoid Compound. | 2016 | Phytother Res | pmid:27539056 |
| Li J et al. | Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2. | 2016 | Int. Immunopharmacol. | pmid:27764743 |
| Wang YL et al. | Therapeutic potential of Oroxylin A in rheumatoid arthritis. | 2016 | Int. Immunopharmacol. | pmid:27643663 |
| Hui H et al. | Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27085528 |
| Qiao C et al. | Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. | 2016 | Oncotarget | pmid:26958937 |
| Zhou DG et al. | Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model. | 2016 | Inflammation | pmid:26895180 |
| Wei L et al. | Oroxylin A inhibits invasion and migration through suppressing ERK/GSK-3β signaling in snail-expressing non-small-cell lung cancer cells. | 2016 | Mol. Carcinog. | pmid:26741501 |
| Dai Q et al. | Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. | 2016 | Mol. Carcinog. | pmid:26259145 |
| Huang L et al. | Application of a new method, orthogonal projection to latent structure (OPLS) combined with principal component analysis (PCA), to screening of prostaglandin E2 production inhibitory flavonoids in Scutellaria Root. | 2016 | J Nat Med | pmid:27164908 |
| Kwon BE et al. | Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. | 2016 | PLoS ONE | pmid:27195463 |
| Yang H et al. | Drug activity screening based on microsomes-hydrogel system in predicting metabolism induced antitumor effect of oroxylin A. | 2016 | Sci Rep | pmid:26905263 |
| Tseng TL et al. | Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock. | 2016 | Br. J. Pharmacol. | pmid:26694894 |
| Cho P et al. | Effects of Lead Phytochemicals of Radix Scutellariae on Acanthamoeba. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:27918833 |
| Huang H et al. | Protective effect of oroxylin A against lipopolysaccharide and/or D-galactosamine-induced acute liver injury in mice. | 2015 | J. Surg. Res. | pmid:25818981 |
| Qiao C et al. | UCP2-related mitochondrial pathway participates in oroxylin A-induced apoptosis in human colon cancer cells. | 2015 | J. Cell. Physiol. | pmid:25251374 |
| Zou M et al. | Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway. | 2015 | Mol. Carcinog. | pmid:25213258 |
| Li X et al. | Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway. | 2015 | Arch. Toxicol. | pmid:24671465 |
| Zhao K et al. | Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. | 2015 | J Hematol Oncol | pmid:25902914 |
| Wei L et al. | Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. | 2015 | Cell Death Dis | pmid:25855962 |
| Li C et al. | Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. | 2014 | Pharm Biol | pmid:24102566 |
| Fong SY et al. | Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. | 2014 | J Pharm Biomed Anal | pmid:24803030 |
| Fong SY and Zuo Z | Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. | 2014 | Xenobiotica | pmid:24168065 |
| Singh J and Kakkar P | Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells. | 2014 | Phytomedicine | pmid:25442284 |
| Ye M et al. | Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation. | 2014 | Biochem. Cell Biol. | pmid:25247252 |
| Kim DH et al. | Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice. | 2014 | Brain Res. Bull. | pmid:25218897 |
| Hui H et al. | Oroxylin A inhibits ATRA-induced IL-6 expression involved in retinoic acid syndrome by down-regulating CHOP. | 2014 | Gene | pmid:25192658 |
| Cheng Y et al. | Oroxylin A inhibits hypoxia-induced invasion and migration of MCF-7 cells by suppressing the Notch pathway. | 2014 | Anticancer Drugs | pmid:24637576 |
| Ku SK et al. | Antithrombotic activities of oroxylin A in vitro and in vivo. | 2014 | Arch. Pharm. Res. | pmid:23963976 |
| Yao J et al. | Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling. | 2014 | Mol. Carcinog. | pmid:22949302 |
| Ku SK et al. | Inhibitory effects of oroxylin A on endothelial protein C receptor shedding in vitro and in vivo. | 2014 | BMB Rep | pmid:24286327 |
| Hui H et al. | Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα. | 2014 | Int. J. Cancer | pmid:23934681 |
| Wang Y et al. | CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells. | 2014 | Biochem. Pharmacol. | pmid:24858801 |
| Zhu L et al. | Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest. | 2013 | Toxicol. Lett. | pmid:23470866 |
| Wei L et al. | Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II. | 2013 | Biochim. Biophys. Acta | pmid:23500080 |
| Yang X et al. | Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. | 2013 | Inflamm. Bowel Dis. | pmid:23823704 |
| Wei L et al. | Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma. | 2013 | Cell Death Dis | pmid:23598413 |
| Dong J et al. | Oroxylin A inhibits hemolysis via hindering the self-assembly of α-hemolysin heptameric transmembrane pore. | 2013 | PLoS Comput. Biol. | pmid:23349625 |
| Yoon SY et al. | Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro. | 2013 | Arch. Pharm. Res. | pmid:23371806 |
| Liu X et al. | The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice. | 2013 | Arch. Pharm. Res. | pmid:23543630 |
| dela Peña IC et al. | 5,7-Dihydroxy-6-methoxy-4'-phenoxyflavone, a derivative of oroxylin A improves attention-deficit/hyperactivity disorder (ADHD)-like behaviors in spontaneously hypertensive rats. | 2013 | Eur. J. Pharmacol. | pmid:23707903 |
| Wang H et al. | An estrogen receptor dependent mechanism of Oroxylin A in the repression of inflammatory response. | 2013 | PLoS ONE | pmid:23922737 |
| Zhu R et al. | Oroxylin A accelerates liver regeneration in CClâ‚„-induced acute liver injury mice. | 2013 | PLoS ONE | pmid:23951204 |
| Dai Q et al. | Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23612020 |
| Qiu J et al. | Molecular modeling reveals the novel inhibition mechanism and binding mode of three natural compounds to staphylococcal α-hemolysin. | 2013 | PLoS ONE | pmid:24312202 |
| Kim DH et al. | 4'-bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-κB signaling pathway in RAW 264.7 macrophages. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22101131 |
| Yang HY et al. | Oroxylin A reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-κB signaling pathway. | 2012 | Mol. Carcinog. | pmid:21557331 |
| Zou M et al. | Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. | 2012 | Cell. Signal. | pmid:22560876 |
| Hu R et al. | The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors. | 2012 | Anticancer Drugs | pmid:22526619 |
| Ha J et al. | Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway. | 2012 | Biochem. Cell Biol. | pmid:22607196 |
| Xu M et al. | Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cells. | 2012 | Toxicol. Lett. | pmid:22609744 |
| Lu Z et al. | Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway. | 2012 | Toxicol. Lett. | pmid:22245252 |
| Zhu B et al. | Oroxylin A reverses CAM-DR of HepG2 cells by suppressing Integrinβ1 and its related pathway. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22310179 |
| Fu W et al. | Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22196122 |
| Tong L et al. | Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. | 2012 | J Pharm Biomed Anal | pmid:22703838 |
| Pham TA et al. | Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22366656 |
| Wang H et al. | [Vasodilator effect of oroxylin A on thoracic aorta isolated from rats]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22883404 |
| Song X et al. | Oroxylin A, a classical natural product, shows a novel inhibitory effect on angiogenesis induced by lipopolysaccharide. | 2012 | Pharmacol Rep | pmid:23238475 |
| Liu PW et al. | STAT1 mediates oroxylin a inhibition of iNOS and pro-inflammatory cytokines expression in microglial BV-2 cells. | 2012 | PLoS ONE | pmid:23236370 |
| Guo H et al. | [Preparation of flavonoid reference standards from Scutellariae Radix under the guidance of high performance liquid chromatography-mass spectrometry analysis]. | 2012 | Se Pu | pmid:23189664 |
| Tseng TL et al. | Oroxylin-A rescues LPS-induced acute lung injury via regulation of NF-κB signaling pathway in rodents. | 2012 | PLoS ONE | pmid:23071799 |
| Lu QY et al. | Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. | 2012 | Pancreas | pmid:22158070 |
| Li C et al. | Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. | 2012 | AAPS J | pmid:22167378 |
| Jeon SJ et al. | Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture. | 2011 | Neurosci. Res. | pmid:21145362 |
| Li C et al. | Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. | 2011 | J Pharm Biomed Anal | pmid:21051171 |
| Lee S et al. | Oroxylin A, a flavonoid, stimulates adult neurogenesis in the hippocampal dentate gyrus region of mice. | 2010 | Neurochem. Res. | pmid:20680459 |
| Zhao L et al. | Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. | 2010 | Cancer Chemother. Pharmacol. | pmid:19585117 |
| Gao Y et al. | Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylation. | 2010 | J. Cancer Res. Clin. Oncol. | pmid:19888602 |
| Zhou Q et al. | Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. | 2010 | Pharm. Res. | pmid:20411407 |
| Marques MR et al. | Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers. | 2010 | Fitoterapia | pmid:20117183 |
| Kumar GS et al. | Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors. | 2010 | J Asian Nat Prod Res | pmid:21061220 |
| Trinh HT et al. | Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice. | 2010 | Acta Pharmacol. Sin. | pmid:20453872 |
| Shih HC et al. | In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. | 2009 | J. Biomed. Sci. | pmid:19272127 |
| Go WJ et al. | Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. | 2009 | J. Nat. Prod. | pmid:19739602 |
| Li HN et al. | Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. | 2009 | Toxicology | pmid:19135124 |
| Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
| Zhou XQ et al. | [Flavonoids from Scutellaria baicalensis and their bioactivities]. | 2009 | Beijing Da Xue Xue Bao | pmid:19829679 |