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Determination of oroxylin A and oroxylin A 7-O-d-glucuronide in HepG2 cell lysate and subcellular fractions with SPE-UPLC-MS/MS: Cellular pharmacokinetic study to indicate anti-cancer mechanisms. |
2018 |
J Pharm Biomed Anal |
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Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation. |
2018 |
Int. Immunopharmacol. |
pmid:29414645
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Jin H et al. |
Oroxylin A inhibits ethanol-induced hepatocyte senescence via YAP pathway. |
2018 |
Cell Prolif. |
pmid:29318697
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Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs. |
2018 |
Biomed. Pharmacother. |
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Wu SC et al. |
Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response. |
2018 |
Phytomedicine |
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Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling. |
2018 |
J. Cell. Biochem. |
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Synergistic effect of baicalein, wogonin and oroxylin A mixture: multistep inhibition of the NF-κB signalling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids. |
2018 |
J Nat Med |
pmid:28921127
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Jin H et al. |
Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha. |
2018 |
Chem. Biol. Interact. |
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A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. |
2018 |
Fitoterapia |
pmid:29477305
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Catechol-O-Methyltransferase and UDP-Glucuronosyltransferases in the Metabolism of Baicalein in Different Species. |
2017 |
Eur J Drug Metab Pharmacokinet |
pmid:28536775
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Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. |
2017 |
Mol. Pharm. |
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Screening of six Ayurvedic medicinal plants for anti-obesity potential: An investigation on bioactive constituents from Oroxylum indicum (L.) Kurz bark. |
2017 |
J Ethnopharmacol |
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Chen M et al. |
Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. |
2017 |
Biomed. Chromatogr. |
pmid:28236316
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Han Q et al. |
Oroxylin A inhibits HO-induced oxidative stress in PC12 cells. |
2017 |
Nat. Prod. Res. |
pmid:27820974
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Tan C et al. |
Oroxylin a could be a Promising Radiosensitizer for Esophageal Squamous Cell Carcinoma by Inducing G2/M Arrest and Activating Apoptosis. |
2017 |
Pathol. Oncol. Res. |
pmid:27585443
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Li W et al. |
Oroxylin A reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12/CXCR7 axis in bone marrow microenvironment. |
2017 |
Mol. Carcinog. |
pmid:27533597
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Lin SF et al. |
Oroxylin A promotes retinal ganglion cell survival in a rat optic nerve crush model. |
2017 |
PLoS ONE |
pmid:28640893
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Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. |
2017 |
Cell Death Dis |
pmid:28726775
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Ni T et al. |
Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism. |
2017 |
Cell Death Dis |
pmid:28594405
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Shen L et al. |
Oroxylin A inhibits the generation of Tregs in non-small cell lung cancer. |
2017 |
Oncotarget |
pmid:28472762
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Fu X et al. |
A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications. |
2017 |
Chem. Commun. (Camb.) |
pmid:28286894
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Enhancement of solubility and dissolution rate of baicalein, wogonin and oroxylin A extracted from Radix scutellariae. |
2017 |
Int J Pharm |
pmid:28642200
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Liu RX et al. |
Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis. |
2017 |
Chin J Nat Med |
pmid:28284428
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Zhang YY et al. |
Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase. |
2016 |
FEBS Lett. |
pmid:27432544
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Overview of Oroxylin A: A Promising Flavonoid Compound. |
2016 |
Phytother Res |
pmid:27539056
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Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2. |
2016 |
Int. Immunopharmacol. |
pmid:27764743
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Wang YL et al. |
Therapeutic potential of Oroxylin A in rheumatoid arthritis. |
2016 |
Int. Immunopharmacol. |
pmid:27643663
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Hui H et al. |
Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells. |
2016 |
J. Cancer Res. Clin. Oncol. |
pmid:27085528
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Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. |
2016 |
Oncotarget |
pmid:26958937
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Zhou DG et al. |
Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model. |
2016 |
Inflammation |
pmid:26895180
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Wei L et al. |
Oroxylin A inhibits invasion and migration through suppressing ERK/GSK-3β signaling in snail-expressing non-small-cell lung cancer cells. |
2016 |
Mol. Carcinog. |
pmid:26741501
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Dai Q et al. |
Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. |
2016 |
Mol. Carcinog. |
pmid:26259145
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Huang L et al. |
Application of a new method, orthogonal projection to latent structure (OPLS) combined with principal component analysis (PCA), to screening of prostaglandin E2 production inhibitory flavonoids in Scutellaria Root. |
2016 |
J Nat Med |
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Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. |
2016 |
PLoS ONE |
pmid:27195463
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Drug activity screening based on microsomes-hydrogel system in predicting metabolism induced antitumor effect of oroxylin A. |
2016 |
Sci Rep |
pmid:26905263
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Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock. |
2016 |
Br. J. Pharmacol. |
pmid:26694894
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Cho P et al. |
Effects of Lead Phytochemicals of Radix Scutellariae on Acanthamoeba. |
2016 |
Invest. Ophthalmol. Vis. Sci. |
pmid:27918833
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Huang H et al. |
Protective effect of oroxylin A against lipopolysaccharide and/or D-galactosamine-induced acute liver injury in mice. |
2015 |
J. Surg. Res. |
pmid:25818981
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UCP2-related mitochondrial pathway participates in oroxylin A-induced apoptosis in human colon cancer cells. |
2015 |
J. Cell. Physiol. |
pmid:25251374
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Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway. |
2015 |
Mol. Carcinog. |
pmid:25213258
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Li X et al. |
Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway. |
2015 |
Arch. Toxicol. |
pmid:24671465
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Zhao K et al. |
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. |
2015 |
J Hematol Oncol |
pmid:25902914
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Wei L et al. |
Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. |
2015 |
Cell Death Dis |
pmid:25855962
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Singh J and Kakkar P |
Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells. |
2014 |
Phytomedicine |
pmid:25442284
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Ye M et al. |
Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation. |
2014 |
Biochem. Cell Biol. |
pmid:25247252
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Kim DH et al. |
Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice. |
2014 |
Brain Res. Bull. |
pmid:25218897
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Yao J et al. |
Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling. |
2014 |
Mol. Carcinog. |
pmid:22949302
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Ku SK et al. |
Inhibitory effects of oroxylin A on endothelial protein C receptor shedding in vitro and in vivo. |
2014 |
BMB Rep |
pmid:24286327
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Hui H et al. |
Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα. |
2014 |
Int. J. Cancer |
pmid:23934681
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Wang Y et al. |
CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells. |
2014 |
Biochem. Pharmacol. |
pmid:24858801
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