Oroxylin A

Oroxylin A is a lipid of Polyketides (PK) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 747 references associated with Oroxylin A in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Oroxylin A

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Oroxylin A

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Seizures D012640 87 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Per page 10 20 | Total 12

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All references with Oroxylin A

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Per page 10 20 50 100 | Total 124
Authors Title Published Journal PubMed Link
Zhang Q et al. Determination of oroxylin A and oroxylin A 7-O-d-glucuronide in HepG2 cell lysate and subcellular fractions with SPE-UPLC-MS/MS: Cellular pharmacokinetic study to indicate anti-cancer mechanisms. 2018 J Pharm Biomed Anal pmid:29571134
Chen W et al. Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation. 2018 Int. Immunopharmacol. pmid:29414645
Jin H et al. Oroxylin A inhibits ethanol-induced hepatocyte senescence via YAP pathway. 2018 Cell Prolif. pmid:29318697
Jin J et al. Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs. 2018 Biomed. Pharmacother. pmid:29091888
Wu SC et al. Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response. 2018 Phytomedicine pmid:30195877
Zhang C et al. Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling. 2018 J. Cell. Biochem. pmid:28857294
Shimizu T et al. Synergistic effect of baicalein, wogonin and oroxylin A mixture: multistep inhibition of the NF-κB signalling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids. 2018 J Nat Med pmid:28921127
Jin H et al. Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha. 2018 Chem. Biol. Interact. pmid:29476730
Chassagne F et al. A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. 2018 Fitoterapia pmid:29477305
Zhang R et al. Catechol-O-Methyltransferase and UDP-Glucuronosyltransferases in the Metabolism of Baicalein in Different Species. 2017 Eur J Drug Metab Pharmacokinet pmid:28536775
Fong SYK et al. Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. 2017 Mol. Pharm. pmid:28426226
Mangal P et al. Screening of six Ayurvedic medicinal plants for anti-obesity potential: An investigation on bioactive constituents from Oroxylum indicum (L.) Kurz bark. 2017 J Ethnopharmacol pmid:27469197
Chen M et al. Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. 2017 Biomed. Chromatogr. pmid:28236316
Han Q et al. Oroxylin A inhibits HO-induced oxidative stress in PC12 cells. 2017 Nat. Prod. Res. pmid:27820974
Tan C et al. Oroxylin a could be a Promising Radiosensitizer for Esophageal Squamous Cell Carcinoma by Inducing G2/M Arrest and Activating Apoptosis. 2017 Pathol. Oncol. Res. pmid:27585443
Li W et al. Oroxylin A reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12/CXCR7 axis in bone marrow microenvironment. 2017 Mol. Carcinog. pmid:27533597
Lin SF et al. Oroxylin A promotes retinal ganglion cell survival in a rat optic nerve crush model. 2017 PLoS ONE pmid:28640893
Wei L et al. Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. 2017 Cell Death Dis pmid:28726775
Ni T et al. Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism. 2017 Cell Death Dis pmid:28594405
Shen L et al. Oroxylin A inhibits the generation of Tregs in non-small cell lung cancer. 2017 Oncotarget pmid:28472762
Fu X et al. A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications. 2017 Chem. Commun. (Camb.) pmid:28286894
Yu H et al. Enhancement of solubility and dissolution rate of baicalein, wogonin and oroxylin A extracted from Radix scutellariae. 2017 Int J Pharm pmid:28642200
Liu RX et al. Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis. 2017 Chin J Nat Med pmid:28284428
Zhang YY et al. Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase. 2016 FEBS Lett. pmid:27432544
Lu L et al. Overview of Oroxylin A: A Promising Flavonoid Compound. 2016 Phytother Res pmid:27539056
Li J et al. Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2. 2016 Int. Immunopharmacol. pmid:27764743
Wang YL et al. Therapeutic potential of Oroxylin A in rheumatoid arthritis. 2016 Int. Immunopharmacol. pmid:27643663
Hui H et al. Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells. 2016 J. Cancer Res. Clin. Oncol. pmid:27085528
Qiao C et al. Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. 2016 Oncotarget pmid:26958937
Zhou DG et al. Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model. 2016 Inflammation pmid:26895180
Wei L et al. Oroxylin A inhibits invasion and migration through suppressing ERK/GSK-3β signaling in snail-expressing non-small-cell lung cancer cells. 2016 Mol. Carcinog. pmid:26741501
Dai Q et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. 2016 Mol. Carcinog. pmid:26259145
Huang L et al. Application of a new method, orthogonal projection to latent structure (OPLS) combined with principal component analysis (PCA), to screening of prostaglandin E2 production inhibitory flavonoids in Scutellaria Root. 2016 J Nat Med pmid:27164908
Kwon BE et al. Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. 2016 PLoS ONE pmid:27195463
Yang H et al. Drug activity screening based on microsomes-hydrogel system in predicting metabolism induced antitumor effect of oroxylin A. 2016 Sci Rep pmid:26905263
Tseng TL et al. Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock. 2016 Br. J. Pharmacol. pmid:26694894
Cho P et al. Effects of Lead Phytochemicals of Radix Scutellariae on Acanthamoeba. 2016 Invest. Ophthalmol. Vis. Sci. pmid:27918833
Huang H et al. Protective effect of oroxylin A against lipopolysaccharide and/or D-galactosamine-induced acute liver injury in mice. 2015 J. Surg. Res. pmid:25818981
Qiao C et al. UCP2-related mitochondrial pathway participates in oroxylin A-induced apoptosis in human colon cancer cells. 2015 J. Cell. Physiol. pmid:25251374
Zou M et al. Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway. 2015 Mol. Carcinog. pmid:25213258
Li X et al. Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway. 2015 Arch. Toxicol. pmid:24671465
Zhao K et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. 2015 J Hematol Oncol pmid:25902914
Wei L et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. 2015 Cell Death Dis pmid:25855962
Singh J and Kakkar P Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells. 2014 Phytomedicine pmid:25442284
Ye M et al. Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation. 2014 Biochem. Cell Biol. pmid:25247252
Kim DH et al. Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice. 2014 Brain Res. Bull. pmid:25218897
Yao J et al. Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling. 2014 Mol. Carcinog. pmid:22949302
Ku SK et al. Inhibitory effects of oroxylin A on endothelial protein C receptor shedding in vitro and in vivo. 2014 BMB Rep pmid:24286327
Hui H et al. Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα. 2014 Int. J. Cancer pmid:23934681
Wang Y et al. CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells. 2014 Biochem. Pharmacol. pmid:24858801