Scutellarein 7-glucuronide is a lipid of Polyketides (PK) class.
We collected disease MeSH terms mapped to the references associated with Scutellarein 7-glucuronide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen S et al. | A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Extract. | 2018 | Molecules | pmid:30037063 |
| Zhu J et al. | Protective effects of Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models. | 2018 | Mol. Vis. | pmid:29769797 |
| You P et al. | Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-κB and p38/JNK pathway in LPS-induced BV-2 microglial cells. | 2018 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:29680917 |
| Zhang X et al. | Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. | 2018 | Free Radic. Res. | pmid:29400110 |
| Wang J et al. | Scutellarin enhances osteoblast proliferation and function via NF-κB-mediated CXCR4 induction. | 2018 | Gene | pmid:29936266 |
| Mo J et al. | Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation. | 2018 | Phytomedicine | pmid:29655699 |
| Zeng YQ et al. | Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice. | 2018 | Molecules | pmid:29642616 |
| Chledzik S et al. | Pharmacological Effects of Scutellarin, An Active Component of Genus Scutellaria and Erigeron: A Systematic Review. | 2018 | Am. J. Chin. Med. | pmid:29433387 |
| Ni G et al. | Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells. | 2018 | Molecules | pmid:29389889 |
| Baluchnejadmojarad T et al. | Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. | 2018 | Int. Immunopharmacol. | pmid:29190543 |
| Yang B et al. | Pharmacokinetic comparison of seven major bioactive components in normal and depression model rats after oral administration of Baihe Zhimu decoction by liquid chromatography-tandem mass spectrometry. | 2018 | J Pharm Biomed Anal | pmid:28987996 |
| Shin JW et al. | Scutellarin Ameliorates Learning and Memory Deficit via Suppressing [Formula: see text]-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion. | 2018 | Am. J. Chin. Med. | pmid:30149759 |
| You L et al. | Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. | 2017 | Bioorg. Med. Chem. Lett. | pmid:29157862 |
| Gao C et al. | Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. | 2017 | Oncol. Rep. | pmid:28737827 |
| Gu T et al. | Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. | 2017 | Molecules | pmid:28635646 |
| Spilovska K et al. | Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. | 2017 | Molecules | pmid:28621747 |
| Wang J et al. | Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy. | 2017 | J Nanobiotechnology | pmid:28249594 |
| Yang LL et al. | Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. | 2017 | Biochim Biophys Acta Mol Basis Dis | pmid:27903431 |
| Sun XP et al. | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. | 2017 | Arch. Pharm. Res. | pmid:28315259 |
| Yao H et al. | DPPH·-luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis. | 2017 | Luminescence | pmid:27860193 |
| Fan H et al. | Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. | 2017 | Med. Sci. Monit. | pmid:29172017 |
| Hou L et al. | Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. | 2017 | Med. Sci. Monit. | pmid:29079722 |
| Zhang L et al. | Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. | 2017 | Mol Med Rep | pmid:28849116 |
| Liu S and Ho PC | Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. | 2017 | J. Pharm. Pharmacol. | pmid:28809432 |
| Han T et al. | Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation. | 2017 | Eur J Med Chem | pmid:28458133 |
| Li J et al. | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28611514 |
| Yang N et al. | Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. | 2017 | Mol Med Rep | pmid:28035355 |
| Ke Y et al. | Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998773 |
| Wu CY et al. | Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. | 2017 | Curr. Med. Chem. | pmid:27855618 |
| Wang J et al. | Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. | 2017 | Int J Nanomedicine | pmid:29158673 |
| Li Y et al. | Pharmacokinetic Comparison of Scutellarin and Paeoniflorin in Sham-Operated and Middle Cerebral Artery Occlusion Ischemia and Reperfusion Injury Rats after Intravenous Administration of Xin-Shao Formula. | 2016 | Molecules | pmid:27617986 |
| Sun C et al. | Rapid Isolation and Determination of Flavones in Biological Samples Using Zinc Complexation Coupled with High-Performance Liquid Chromatography. | 2016 | Molecules | pmid:27537870 |
| Wang H et al. | Engineering Saccharomyces cerevisiae with the deletion of endogenous glucosidases for the production of flavonoid glucosides. | 2016 | Microb. Cell Fact. | pmid:27491546 |
| Yuan Y et al. | Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia. | 2016 | Neuromolecular Med. | pmid:27103430 |
| Dong ZX et al. | An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. | 2016 | Molecules | pmid:26927039 |
| Wang W et al. | Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor. | 2016 | PLoS ONE | pmid:26730961 |
| Li Q et al. | Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. | 2016 | J Clin Neurosci | pmid:27742373 |
| Zhao S et al. | Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. | 2016 | Int. Immunopharmacol. | pmid:27728897 |
| Xiao L et al. | A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP. | 2016 | Eur J Pharm Sci | pmid:27586020 |
| Fang M et al. | Scutellarin promotes microglia-mediated astrogliosis coupled with improved behavioral function in cerebral ischemia. | 2016 | Neurochem. Int. | pmid:27105682 |
| Jiang Z et al. | Determination of scutellarin in breviscapine preparations using quantitative proton nuclear magnetic resonance spectroscopy. | 2016 | J Food Drug Anal | pmid:28911594 |
| Wang Z et al. | Scutellarin protects cardiomyocyte ischemia-reperfusion injury by reducing apoptosis and oxidative stress. | 2016 | Life Sci. | pmid:26775564 |
| Wang WW et al. | Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells. | 2016 | J. Mol. Neurosci. | pmid:26514969 |
| Fang M et al. | Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats. | 2015 | BMC Neurosci | pmid:26608466 |
| Li L et al. | Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα. | 2015 | PLoS ONE | pmid:26440524 |
| Cattaneo L et al. | Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells. | 2015 | PLoS ONE | pmid:26176704 |
| Tang H et al. | Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult. | 2015 | PLoS ONE | pmid:26147971 |
| Zhang W et al. | A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin. | 2015 | Molecules | pmid:26042857 |
| Long L et al. | Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat. | 2015 | J Diabetes Res | pmid:25861655 |
| Chen RB et al. | Deep Sequencing Reveals the Effect of MeJA on Scutellarin Biosynthesis in Erigeron breviscapus. | 2015 | PLoS ONE | pmid:26656917 |