| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
Wogonin
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
Cross Reference
Introduction
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Wogonin?
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Wogonin
PubChem Associated disorders and diseases
What pathways are associated with Wogonin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Wogonin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Wogonin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Wogonin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Wogonin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Woźniak D et al. | Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix. | 2015 | Nat. Prod. Res. | pmid:25427178 |
| Islam MN et al. | A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract. | 2012 | Nat. Prod. Res. | pmid:22304335 |
| Cao XD et al. | Antitumor constituents from the leaves of Carya cathayensis. | 2012 | Nat. Prod. Res. | pmid:22007794 |
| Woźniak D et al. | Antimutagenic and antiradical properties of flavones from the roots of Scutellaria baicalensis georgi. | 2004 | Nahrung | pmid:15053344 |
| Hong M et al. | Wogonin Suppresses the Activity of Matrix Metalloproteinase-9 and Inhibits Migration and Invasion in Human Hepatocellular Carcinoma. | 2018 | Molecules | pmid:29439451 |
| Sun C et al. | Rapid Isolation and Determination of Flavones in Biological Samples Using Zinc Complexation Coupled with High-Performance Liquid Chromatography. | 2016 | Molecules | pmid:27537870 |
| Shin HS et al. | Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. | 2014 | Molecules | pmid:24566319 |
| Huan SK et al. | Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. | 2012 | Molecules | pmid:22634839 |
| Li WJ et al. | Phenolic compounds and antioxidant activities of Liriope muscari. | 2012 | Molecules | pmid:22328078 |
| Lee JY and Park W | Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. | 2015 | Molecules | pmid:25913928 |
| Talbi A et al. | Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats. | 2014 | Molecules | pmid:24786691 |
| Chang YL et al. | Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. | 2001 | Mol. Pharmacol. | pmid:11502881 |
| Fong SYK et al. | Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. | 2017 | Mol. Pharm. | pmid:28426226 |
| Xia B et al. | A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. | 2012 | Mol. Pharm. | pmid:23033922 |
| Yu JS and Kim AK | Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. | 2011 | Mol. Cells | pmid:21448585 |
| Khan S et al. | Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties. | 2016 | Mol. Cell. Endocrinol. | pmid:27013352 |
| Zhong Y et al. | Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response. | 2013 | Mol. Carcinog. | pmid:22593043 |
| Wang H et al. | Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. | 2014 | Mol. Carcinog. | pmid:23761018 |
| Zhao L et al. | LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells. | 2016 | Mol. Carcinog. | pmid:25945460 |
| Zhao Y et al. | Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway. | 2015 | Mol. Carcinog. | pmid:24976450 |
| Song X et al. | Wogonin influences vascular permeability via Wnt/β-catenin pathway. | 2015 | Mol. Carcinog. | pmid:24136474 |
| Seo DC et al. | Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells. | 2007 | Mol. Cancer | pmid:18034892 |
| Parekh HS et al. | A new dawn for the use of traditional Chinese medicine in cancer therapy. | 2009 | Mol. Cancer | pmid:19298677 |
| Zhao Q et al. | Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis. | 2018 | Mol Plant | pmid:28842248 |
| Chen LG et al. | Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. | 2008 | Mol Nutr Food Res | pmid:18496814 |
| Wang J et al. | Mediating macrophage immunity with wogonin in mice with vascular inflammation. | 2017 | Mol Med Rep | pmid:28983597 |
| Lu H et al. | Wogonin inhibits the proliferation of myelodysplastic syndrome cells through the induction of cell cycle arrest and apoptosis. | 2015 | Mol Med Rep | pmid:26398525 |
| Kim SJ et al. | Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. | 2012 | Mol Med Rep | pmid:22992837 |
| Lin B | Polyphenols and neuroprotection against ischemia and neurodegeneration. | 2011 | Mini Rev Med Chem | pmid:22070681 |
| Van Dien M et al. | Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice. | 2001 | Microbiol. Immunol. | pmid:11791668 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Koppula S et al. | Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease. | 2012 | Mediators Inflamm. | pmid:22577256 |
| Zhu N et al. | Characterization and Bioavailability of Wogonin by Different Administration Routes in Beagles. | 2016 | Med. Sci. Monit. | pmid:27744456 |
| Lin Z et al. | Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds. | 2008 Nov-Dec | Luminescence | pmid:18506909 |
| Lee CY et al. | Chemopreventive effect of selenium and Chinese medicinal herbs on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in Syrian hamsters. | 2008 | Liver Int. | pmid:18346132 |
| Ueng YF et al. | Effects of baicalein and wogonin on drug-metabolizing enzymes in C57BL/6J mice. | 2000 | Life Sci. | pmid:11045600 |
| Zhang M et al. | Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. | 2013 | Life Sci. | pmid:23142241 |
| Lu N et al. | Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. | 2008 | Life Sci. | pmid:18378261 |
| Meng XM et al. | Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis. | 2018 | Lab. Invest. | pmid:29200200 |
| Nagaki Y et al. | Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits. | 2001 May-Jun | Jpn. J. Ophthalmol. | pmid:11369368 |
| Nagaki Y et al. | Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits. | 2003 May-Jun | Jpn. J. Ophthalmol. | pmid:12782159 |
| Tian J et al. | Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA. | 2004 | J. Photochem. Photobiol. B, Biol. | pmid:15043845 |
| Lim H et al. | Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. | 2011 | J. Pharmacol. Sci. | pmid:21606625 |
| Enomoto R et al. | Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action. | 2007 | J. Pharmacol. Sci. | pmid:17690528 |
| Xie S et al. | Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9. | 2011 | J. Pharm. Pharmacol. | pmid:21235595 |
| Yeh YC et al. | Acute lung injury induced by lipopolysaccharide is inhibited by wogonin in mice via reduction of Akt phosphorylation and RhoA activation. | 2016 | J. Pharm. Pharmacol. | pmid:26749510 |
| Chen CY et al. | Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. | 2011 | J. Nutr. Biochem. | pmid:21190831 |
| Parajuli P et al. | Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling. | 2011 | J. Neurooncol. | pmid:20467782 |
| Li J et al. | Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. | 2009 | J. Nat. Prod. | pmid:19555121 |
| Chen F et al. | Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway. | 2015 | J. Mol. Neurosci. | pmid:25417142 |