| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Penile Induration | D010411 | 4 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Myocardial Reperfusion Injury | D015428 | 20 associated lipids |
Wogonin
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
Cross Reference
Introduction
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Wogonin?
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Wogonin
PubChem Associated disorders and diseases
What pathways are associated with Wogonin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Wogonin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Wogonin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Wogonin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Wogonin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shao YX et al. | The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. | 2012 | Eur. Biophys. J. | pmid:22228220 |
| Sabra SA et al. | Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer. | 2018 | Eur J Pharm Biopharm | pmid:29689288 |
| Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
| Zhang F and Wang G | A review of non-nucleoside anti-hepatitis B virus agents. | 2014 | Eur J Med Chem | pmid:24549242 |
| Wang J et al. | Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro. | 2017 | Eur J Med Chem | pmid:28987604 |
| Li T et al. | Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. | 2011 | Eur J Drug Metab Pharmacokinet | pmid:21713461 |
| Zhang Y et al. | The Influence of Compatibility of Rhubarb and Radix Scutellariae on the Pharmacokinetics of Anthraquinones and Flavonoids in Rat Plasma. | 2018 | Eur J Drug Metab Pharmacokinet | pmid:29134502 |
| Boozari M et al. | Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25546119 |
| Yeh CH et al. | Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. | 2014 | Environ. Toxicol. | pmid:23362215 |
| Wei CY et al. | Protective effect of wogonin on endotoxin-induced acute lung injury via reduction of p38 MAPK and JNK phosphorylation. | 2017 | Environ. Toxicol. | pmid:26892447 |
| Huang FM et al. | BisGMA-induced cytotoxicity and genotoxicity in macrophages are attenuated by wogonin via reduction of intrinsic caspase pathway activation. | 2016 | Environ. Toxicol. | pmid:26756871 |
| Sun HL et al. | Endotoxin-induced acute lung injury in mice is protected by 5,7-dihydroxy-8-methoxyflavone via inhibition of oxidative stress and HIF-1α. | 2016 | Environ. Toxicol. | pmid:26213241 |
| Yang T et al. | Wogonin enhances intracellular adiponectin levels and suppresses adiponectin secretion in 3T3-L1 adipocytes. | 2017 | Endocr. J. | pmid:27667474 |
| Si D et al. | Mechanism of CYP2C9 inhibition by flavones and flavonols. | 2009 | Drug Metab. Dispos. | pmid:19074529 |
| Tian J et al. | A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. | 2014 | Drug Deliv | pmid:24215357 |
| Chen SS et al. | Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. | 2012 | Discov Med | pmid:23200064 |
| Chen SS et al. | Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. | 2012 | Discov Med | pmid:22284780 |
| Park S et al. | Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. | 2004 | Dig. Dis. Sci. | pmid:15139485 |
| Yan T et al. | Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells. | 2014 | Diagn Pathol | pmid:25432585 |
| Gasiorowski K et al. | Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? | 2011 | CNS Neurol Disord Drug Targets | pmid:21222632 |
| Tai MC et al. | Therapeutic potential of wogonin: a naturally occurring flavonoid. | 2005 | CNS Drug Rev | pmid:16007236 |
| Samarghandian S et al. | Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. | 2011 | Clinics (Sao Paulo) | pmid:21808878 |
| Bonham M et al. | Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. | 2005 | Clin. Cancer Res. | pmid:15897592 |
| Bak EJ et al. | Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. | 2014 | Clin Nutr | pmid:23623334 |
| Hsieh CJ et al. | Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. | 2007 | Clin Mol Allergy | pmid:18039391 |
| Chi DS et al. | Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway. | 2012 | Clin Mol Allergy | pmid:22309647 |
| Xu PP et al. | Wogonin Inhibits Growth of Mantle Cell Lymphoma Cells through Nuclear Factor-κB Signaling Pathway. | 2018 | Chin. Med. J. | pmid:29451160 |
| Peng MX et al. | Apoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin. | 2016 | Chin. Med. J. | pmid:27958228 |
| Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
| Tilton R et al. | A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. | 2010 | Chin Med | pmid:20727161 |
| Su SY and Hsieh CL | Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | 2011 | Chin Med | pmid:21740583 |
| Liu RX et al. | Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis. | 2017 | Chin J Nat Med | pmid:28284428 |
| Huynh DL et al. | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways. | 2017 | Chin J Nat Med | pmid:28259249 |
| Xie LH et al. | Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatography. | 2002 | Chem. Pharm. Bull. | pmid:12130846 |
| Huang WH et al. | Novel synthesis of flavonoids of Scutellaria baicalensis Georgi. | 2003 | Chem. Pharm. Bull. | pmid:12612426 |
| Li YQ et al. | Two new alkaloids from Capparis himalayensis. | 2008 | Chem. Pharm. Bull. | pmid:18239306 |
| Khan NM et al. | Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes. | 2017 | Chem. Biol. Interact. | pmid:28688942 |
| Ye G et al. | Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry. | 2010 | Chem. Biodivers. | pmid:21162005 |
| Su S et al. | Genetic characterization and phytochemical analysis of wild and cultivated populations of Scutellaria baicalensis. | 2008 | Chem. Biodivers. | pmid:18651621 |
| Tan CX et al. | Activities of wogonin analogs and other flavones against Flavobacterium columnare. | 2015 | Chem. Biodivers. | pmid:25676507 |
| Willimott S et al. | An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells. | 2009 | Chem Cent J | pmid:19785738 |
| Lee DH et al. | Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. | 2012 | Cell. Signal. | pmid:22846543 |
| Sukkar B et al. | Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin. | 2018 | Cell. Physiol. Biochem. | pmid:30453283 |
| Al-Maghout T et al. | P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes. | 2017 | Cell. Physiol. Biochem. | pmid:28813704 |
| Chen S et al. | Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway. | 2015 | Cell. Mol. Neurobiol. | pmid:25504431 |
| Xu S et al. | Wogonin prevents rat dorsal root ganglion neurons death via inhibiting tunicamycin-induced ER stress in vitro. | 2015 | Cell. Mol. Neurobiol. | pmid:25381475 |
| Yao J et al. | NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. | 2014 | Cell Death Dis | pmid:24901054 |
| Polier G et al. | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. | 2011 | Cell Death Dis | pmid:21776020 |
| Kim MS et al. | Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. | 2013 | Cell Biol. Toxicol. | pmid:23955116 |
| Chen S et al. | Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. | 2011 | Cell Biol. Toxicol. | pmid:20872277 |
| Li-Weber M | New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. | 2009 | Cancer Treat. Rev. | pmid:19004559 |
| Yang L et al. | Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis. | 2011 | Cancer Sci. | pmid:21244577 |
| Zhang K et al. | Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. | 2008 | Cancer Sci. | pmid:18377421 |
| Himeji M et al. | Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. | 2007 | Cancer Lett. | pmid:16497434 |
| Ishii K et al. | Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. | 2010 | Cancer Invest. | pmid:19863351 |
| Dandawate S et al. | Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity. | 2012 | Cancer Immunol. Immunother. | pmid:22057676 |
| Chow SE et al. | Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. | 2011 | Cancer Chemother. Pharmacol. | pmid:21207227 |
| Enomoto R et al. | Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. | 2011 | Cancer Chemother. Pharmacol. | pmid:20658136 |
| Lee HH et al. | Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. | 2003 | Brain Res. | pmid:12965234 |
| Rushworth SA and Micheau O | Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. | 2009 | Br. J. Pharmacol. | pmid:19664138 |
| Lee DH et al. | Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. | 2009 | Br. J. Pharmacol. | pmid:19438509 |
| Ahn SH et al. | Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. | 2011 | BMC Neurosci | pmid:21810275 |
| Huynh DL et al. | Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression. | 2017 | BMC Complement Altern Med | pmid:28606135 |
| Wu X et al. | Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway. | 2017 | BMC Cancer | pmid:28222771 |
| Wu B et al. | Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. | 2011 | BMC Cancer | pmid:22204275 |
| Tang H et al. | The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. | 2011 | BMC Biol. | pmid:21418589 |
| Ijaz AZ et al. | MKEM: a Multi-level Knowledge Emergence Model for mining undiscovered public knowledge. | 2010 | BMC Bioinformatics | pmid:20406501 |
| Scuro LS et al. | Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation. | 2004 | BMC Biochem. | pmid:15102332 |
| Ku SK and Bae JS | Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo. | 2015 | BMB Rep | pmid:25739393 |
| Kong EK et al. | Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. | 2010 | BMB Rep | pmid:20423617 |
| Fas SC et al. | Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. | 2006 | Blood | pmid:16931628 |
| Ma Z et al. | Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. | 2005 | Blood | pmid:15626742 |
| Baumann S et al. | Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. | 2008 | Blood | pmid:18070986 |
| Wang Z et al. | Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells. | 2003 | BJU Int. | pmid:14616461 |
| Wilczańska-Barska A et al. | Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. | 2012 | Biotechnol. Lett. | pmid:22639092 |
| Yamashita Y et al. | Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation. | 2017 | Biosci. Biotechnol. Biochem. | pmid:28345416 |
| Huang WH et al. | Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. | 2006 | Biosci. Biotechnol. Biochem. | pmid:17031041 |
| Lim BO et al. | Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12834292 |
| Lim BO | Efficacy of wogonin in the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618621 |
| Cui X et al. | Traditional Chinese medicine and related active compounds against hepatitis B virus infection. | 2010 | Biosci Trends | pmid:20448340 |
| Xu H et al. | Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. | 2010 | Bioresour. Technol. | pmid:20708926 |
| Li C et al. | Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. | 2011 | Biopharm Drug Dispos | pmid:21928297 |
| Pham TA et al. | Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22366656 |
| Tran TD et al. | Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19233646 |
| Bian J et al. | Synthesis, evaluation and quantitative structure-activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28117202 |
| Tian J et al. | Interaction of wogonin with bovine serum albumin. | 2005 | Bioorg. Med. Chem. | pmid:15911327 |
| Qin X et al. | Novel platinum(IV) complexes conjugated with a wogonin derivative as multi-targeted anticancer agents. | 2017 | Bioorg. Med. Chem. | pmid:28314511 |
| Chen J et al. | Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPARα/AdipoR2, in vivo and in vitro. | 2017 | Biomed. Pharmacother. | pmid:28486193 |
| Li C et al. | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations. | 2005 | Biomed. Chromatogr. | pmid:15627280 |
| Chen M et al. | Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. | 2017 | Biomed. Chromatogr. | pmid:28236316 |
| Zhang YY et al. | Comparative study of Scutellaria planipes and Scutellaria baicalensis. | 1998 Jan-Feb | Biomed. Chromatogr. | pmid:9470972 |
| Chen J et al. | Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study. | 2011 | Biomed. Chromatogr. | pmid:21154891 |
| Zan B et al. | Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics. | 2011 | Biomed. Chromatogr. | pmid:20872909 |
| Ruibin J et al. | Therapy Effects of Wogonin on Ovarian Cancer Cells. | 2017 | Biomed Res Int | pmid:29181409 |
| Lin YT et al. | Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. | 2003 | Biol. Pharm. Bull. | pmid:12736527 |
| Lai MY et al. | Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. | 2003 | Biol. Pharm. Bull. | pmid:12520178 |
| Zuo F et al. | Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats. | 2003 | Biol. Pharm. Bull. | pmid:12843610 |
| Zuo F et al. | Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora. | 2002 | Biol. Pharm. Bull. | pmid:12033492 |
| Han CK et al. | Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism. | 2005 | Biol. Pharm. Bull. | pmid:16079475 |
| Cho J and Lee HK | Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. | 2004 | Biol. Pharm. Bull. | pmid:15467195 |