Chen SS et al. |
Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. |
2012 |
Discov Med |
pmid:23200064
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Chen CC et al. |
Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. |
2012 |
PLoS ONE |
pmid:22272328
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Xia Y et al. |
A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. |
2012 |
J Pharm Biomed Anal |
pmid:22906689
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Shao YX et al. |
The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. |
2012 |
Eur. Biophys. J. |
pmid:22228220
|
Li J et al. |
Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. |
2012 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:22192416
|
Huang KF et al. |
Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. |
2012 |
Int. Immunopharmacol. |
pmid:22182776
|
Cheng J et al. |
Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. |
2012 |
Int J Nanomedicine |
pmid:22745547
|
He F et al. |
Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. |
2012 |
Oncol. Rep. |
pmid:22665077
|
Shih HC and Yang LL |
Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. |
2012 |
Pharm Biol |
pmid:22471999
|
Ma X et al. |
[Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. |
2012 |
Sheng Li Xue Bao |
pmid:22513472
|
Wang L et al. |
Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. |
2012 |
Int J Nanomedicine |
pmid:22359456
|
Lin CM et al. |
Functional role of wogonin in anti-angiogenesis. |
2012 |
Am. J. Chin. Med. |
pmid:22419433
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Lee DH et al. |
Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. |
2012 |
Cell. Signal. |
pmid:22846543
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Chen SS et al. |
Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. |
2012 |
Discov Med |
pmid:22284780
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Li X et al. |
Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. |
2012 |
Evid Based Complement Alternat Med |
pmid:22235229
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Chow SE et al. |
Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. |
2012 |
J. Cell. Biochem. |
pmid:22689083
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Xia B et al. |
A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. |
2012 |
Mol. Pharm. |
pmid:23033922
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Chen S et al. |
Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:23063682
|
Li WJ et al. |
Phenolic compounds and antioxidant activities of Liriope muscari. |
2012 |
Molecules |
pmid:22328078
|
Matsunaga T et al. |
Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers. |
2012 |
Front Pharmacol |
pmid:22319498
|
Qi XF et al. |
Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. |
2012 |
Evid Based Complement Alternat Med |
pmid:21785648
|
Kim SJ et al. |
Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. |
2012 |
Mol Med Rep |
pmid:22992837
|
Eylenstein A et al. |
Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. |
2012 |
J. Biol. Chem. |
pmid:22110130
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Lu QY et al. |
Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts. |
2012 |
Pancreas |
pmid:22158070
|
Li C et al. |
Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. |
2012 |
AAPS J |
pmid:22167378
|
Ding J et al. |
Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. |
2012 |
J. Biol. Chem. |
pmid:22086925
|
Chi DS et al. |
Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway. |
2012 |
Clin Mol Allergy |
pmid:22309647
|
Zhang N et al. |
A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. |
2012 |
Evid Based Complement Alternat Med |
pmid:22272213
|
Zhong Y et al. |
Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response. |
2013 |
Mol. Carcinog. |
pmid:22593043
|
Xu F et al. |
The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. |
2013 |
J Pharm Sci |
pmid:24018852
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Oshima N et al. |
Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1. |
2013 |
J Nat Med |
pmid:22729955
|
Yu C et al. |
Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. |
2013 |
Pharm Biol |
pmid:23738852
|
Wang Y et al. |
GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. |
2013 |
Toxicol. Lett. |
pmid:23872260
|
Zhao L et al. |
Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. |
2013 |
Biochem. Cell Biol. |
pmid:23859016
|
Wang F et al. |
Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1. |
2013 |
Toxicology |
pmid:23246481
|
Kimura Y and Sumiyoshi M |
Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. |
2013 |
Phytomedicine |
pmid:23219337
|
Wang CZ et al. |
Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. |
2013 |
Int. J. Oncol. |
pmid:23337959
|
Yang L et al. |
Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. |
2013 |
Apoptosis |
pmid:23371323
|
Song X et al. |
Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. |
2013 |
Toxicol. Appl. Pharmacol. |
pmid:23707765
|
Zhang M et al. |
Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. |
2013 |
Life Sci. |
pmid:23142241
|
Chengcheng G et al. |
Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. |
2013 |
Afr Health Sci |
pmid:24250287
|
Chen XM et al. |
Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. |
2013 |
PLoS ONE |
pmid:24265759
|
He L et al. |
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. |
2013 |
Toxicology |
pmid:23907061
|
Chirumbolo S |
Anticancer properties of the flavone wogonin. |
2013 |
Toxicology |
pmid:23994129
|
Zhou YQ et al. |
[Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. |
2013 |
Sichuan Da Xue Xue Bao Yi Xue Ban |
pmid:24490490
|
Kim MS et al. |
Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. |
2013 |
Cell Biol. Toxicol. |
pmid:23955116
|
Attia SM et al. |
Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. |
2013 |
Food Chem. Toxicol. |
pmid:23872129
|
Kim SG et al. |
Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas. |
2013 |
J Nat Med |
pmid:22855402
|
Kim TW et al. |
Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. |
2013 |
Planta Med. |
pmid:23818268
|
Lin CC et al. |
Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells. |
2013 Nov-Dec |
In Vivo |
pmid:24292576
|
Xiao JR et al. |
Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. |
2014 |
J Ocul Pharmacol Ther |
pmid:25280175
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Kwak S et al. |
Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. |
2014 |
Toxicol. Appl. Pharmacol. |
pmid:25223693
|
Li C et al. |
Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. |
2014 |
Pharm Biol |
pmid:24102566
|
Fong SY et al. |
Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. |
2014 |
J Pharm Biomed Anal |
pmid:24803030
|
Sikder MA et al. |
Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. |
2014 |
Phytother Res |
pmid:23463646
|
Bak EJ et al. |
Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice. |
2014 |
Clin Nutr |
pmid:23623334
|
Liu J et al. |
Screening of osteoanagenesis-active compounds from Scutellaria baicalensis Georgi by hPDLC/CMC-online-HPLC/MS. |
2014 |
Fitoterapia |
pmid:24393619
|
Fong SY and Zuo Z |
Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. |
2014 |
Xenobiotica |
pmid:24168065
|
Gong WY et al. |
Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro. |
2014 |
Int. J. Oncol. |
pmid:24604573
|
Wang H et al. |
Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. |
2014 |
Mol. Carcinog. |
pmid:23761018
|
Huang KF et al. |
[Experimental study on inhibitory effect of wogonin on proliferation and invasion of breast cancer cells]. |
2014 |
Zhongguo Zhong Yao Za Zhi |
pmid:25039187
|
Shin HS et al. |
Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. |
2014 |
Molecules |
pmid:24566319
|
Yeh CH et al. |
Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. |
2014 |
Environ. Toxicol. |
pmid:23362215
|
Nam KW et al. |
The role of wogonin in controlling SOCS3 expression in neuronal cells. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:25035930
|
Zhang F and Wang G |
A review of non-nucleoside anti-hepatitis B virus agents. |
2014 |
Eur J Med Chem |
pmid:24549242
|
Yao J et al. |
Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. |
2014 |
Immunology |
pmid:24766487
|
Zhang Y et al. |
V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. |
2014 |
Arch. Toxicol. |
pmid:23835921
|
Marsh Z et al. |
Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora. |
2014 |
Phytochemistry |
pmid:25236693
|
Tian SS et al. |
Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis. |
2014 |
Fitoterapia |
pmid:24096161
|
Yan T et al. |
Wogonin modulates hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells. |
2014 |
Diagn Pathol |
pmid:25432585
|
Zhao K et al. |
Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. |
2014 |
PLoS ONE |
pmid:25203554
|
Yang H et al. |
Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. |
2014 |
Oncotarget |
pmid:25149543
|
Yao J et al. |
NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. |
2014 |
Cell Death Dis |
pmid:24901054
|
Talbi A et al. |
Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats. |
2014 |
Molecules |
pmid:24786691
|
Xu X et al. |
Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway. |
2014 |
Biochem. Pharmacol. |
pmid:25264278
|
Hosseinzadeh Z et al. |
Effect of TGFβ on Na+/K+ ATPase activity in megakaryocytes. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:25168590
|
Ku SK and Bae JS |
Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation. |
2014 |
Fitoterapia |
pmid:25020199
|
Zhao K et al. |
Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling. |
2014 |
Eur. J. Pharmacol. |
pmid:24858369
|
Qian C et al. |
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells. |
2014 |
Free Radic. Res. |
pmid:24666416
|
Zhou M et al. |
Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway. |
2014 |
Vascul. Pharmacol. |
pmid:24534483
|
Tian J et al. |
A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. |
2014 |
Drug Deliv |
pmid:24215357
|
Ku SK et al. |
Inhibitory effect of baicalin, baicalein and wogonin on secretory group IIA phospholipase A2. |
2015 |
Arch. Pharm. Res. |
pmid:25564337
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Woźniak D et al. |
Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix. |
2015 |
Nat. Prod. Res. |
pmid:25427178
|
Lee W et al. |
Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo. |
2015 |
Inflammation |
pmid:25249339
|
Liu J et al. |
Deep Sequencing of the Scutellaria baicalensis Georgi Transcriptome Reveals Flavonoid Biosynthetic Profiling and Organ-Specific Gene Expression. |
2015 |
PLoS ONE |
pmid:26317778
|
Ku SK and Bae JS |
Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo. |
2015 |
BMB Rep |
pmid:25739393
|
Qu JT et al. |
Vasodilatory Effect of Wogonin on the Rat Aorta and Its Mechanism Study. |
2015 |
Biol. Pharm. Bull. |
pmid:26632179
|
Lu H et al. |
Wogonin inhibits the proliferation of myelodysplastic syndrome cells through the induction of cell cycle arrest and apoptosis. |
2015 |
Mol Med Rep |
pmid:26398525
|
Zhang YM et al. |
Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. |
2015 |
Acta Pharmacol. Sin. |
pmid:26073326
|
Lee JY and Park W |
Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. |
2015 |
Molecules |
pmid:25913928
|
Lucas CD et al. |
Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation. |
2015 |
Am. J. Respir. Crit. Care Med. |
pmid:25629436
|
Polier G et al. |
Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263. |
2015 |
Int. J. Cancer |
pmid:24895203
|
Tan CX et al. |
Activities of wogonin analogs and other flavones against Flavobacterium columnare. |
2015 |
Chem. Biodivers. |
pmid:25676507
|
Zhu Y and Wang J |
Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer's disease. |
2015 |
Neurol. Sci. |
pmid:25596147
|
Boozari M et al. |
Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. |
2015 |
Environ. Toxicol. Pharmacol. |
pmid:25546119
|
Chen S et al. |
Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25504431
|
Chen F et al. |
Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway. |
2015 |
J. Mol. Neurosci. |
pmid:25417142
|
Xu S et al. |
Wogonin prevents rat dorsal root ganglion neurons death via inhibiting tunicamycin-induced ER stress in vitro. |
2015 |
Cell. Mol. Neurobiol. |
pmid:25381475
|
Zhao Y et al. |
Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway. |
2015 |
Mol. Carcinog. |
pmid:24976450
|
Song X et al. |
Wogonin influences vascular permeability via Wnt/β-catenin pathway. |
2015 |
Mol. Carcinog. |
pmid:24136474
|