Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Chen LG et al. | Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. | 2008 | Mol Nutr Food Res | pmid:18496814 |
Zhang HW et al. | Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation. | 2008 | Eur. J. Pharmacol. | pmid:18577379 |
Piao HZ et al. | Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity. | 2008 | Int. Immunopharmacol. | pmid:18725324 |
Gao J et al. | Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures. | 2008 | J Pharm Pharm Sci | pmid:18445366 |
Lee CY et al. | Chemopreventive effect of selenium and Chinese medicinal herbs on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in Syrian hamsters. | 2008 | Liver Int. | pmid:18346132 |
Anand P et al. | Cancer is a preventable disease that requires major lifestyle changes. | 2008 | Pharm. Res. | pmid:18626751 |
Lee DH et al. | Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. | 2008 | Biochem. Pharmacol. | pmid:18377871 |
Chen S et al. | Down-regulation of androgen-receptor and PSA by phytochemicals. | 2008 | Int. J. Oncol. | pmid:18202763 |
Cole IB et al. | Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: genome size, antioxidant potential and phytochemistry. | 2008 | Planta Med. | pmid:18484546 |
Su S et al. | Genetic characterization and phytochemical analysis of wild and cultivated populations of Scutellaria baicalensis. | 2008 | Chem. Biodivers. | pmid:18651621 |
BÅ‚ach-Olszewska Z et al. | Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. | 2008 | J. Interferon Cytokine Res. | pmid:18771341 |
Kauss T et al. | Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. | 2008 | Arthritis Res. Ther. | pmid:18252009 |
Chung H et al. | Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. | 2008 | Int. J. Cancer | pmid:17957784 |
Kasai A et al. | Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation. | 2008 | Biol. Pharm. Bull. | pmid:18451504 |
Baumann S et al. | Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. | 2008 | Blood | pmid:18070986 |
Li YQ et al. | Two new alkaloids from Capparis himalayensis. | 2008 | Chem. Pharm. Bull. | pmid:18239306 |
Zhang K et al. | Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. | 2008 | Cancer Sci. | pmid:18377421 |
Lu N et al. | Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. | 2008 | Life Sci. | pmid:18378261 |
Lim H and Kim HP | Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. | 2007 | Planta Med. | pmid:17886198 |
Yu J et al. | Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. | 2007 | Phytother Res | pmid:17674423 |