Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Zhang H et al. | A Novel Prostate-Specific Membrane-Antigen (PSMA) Targeted Micelle-Encapsulating Wogonin Inhibits Prostate Cancer Cell Proliferation via Inducing Intrinsic Apoptotic Pathway. | 2016 | Int J Mol Sci | pmid:27196894 |
Huang L et al. | Application of a new method, orthogonal projection to latent structure (OPLS) combined with principal component analysis (PCA), to screening of prostaglandin E2 production inhibitory flavonoids in Scutellaria Root. | 2016 | J Nat Med | pmid:27164908 |
Zhao Q et al. | A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. | 2016 | Sci Adv | pmid:27152350 |
Tu B et al. | Structure-activity relationship study between baicalein and wogonin by spectrometry, molecular docking and microcalorimetry. | 2016 | Food Chem | pmid:27132840 |
Xu X et al. | BM microenvironmental protection of CML cells from imatinib through Stat5/NF-κB signaling and reversal by Wogonin. | 2016 | Oncotarget | pmid:27027438 |
Khan S et al. | Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties. | 2016 | Mol. Cell. Endocrinol. | pmid:27013352 |
Wei CY et al. | Protective effect of wogonin on endotoxin-induced acute lung injury via reduction of p38 MAPK and JNK phosphorylation. | 2017 | Environ. Toxicol. | pmid:26892447 |
Fajol A et al. | Fibroblast growth factor (Fgf) 23 gene transcription depends on actin cytoskeleton reorganization. | 2016 | FEBS Lett. | pmid:26878191 |
Huang FM et al. | BisGMA-induced cytotoxicity and genotoxicity in macrophages are attenuated by wogonin via reduction of intrinsic caspase pathway activation. | 2016 | Environ. Toxicol. | pmid:26756871 |
Yeh YC et al. | Acute lung injury induced by lipopolysaccharide is inhibited by wogonin in mice via reduction of Akt phosphorylation and RhoA activation. | 2016 | J. Pharm. Pharmacol. | pmid:26749510 |