Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tian J et al. | A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. | 2014 | Drug Deliv | pmid:24215357 |
Si D et al. | Mechanism of CYP2C9 inhibition by flavones and flavonols. | 2009 | Drug Metab. Dispos. | pmid:19074529 |
Yang T et al. | Wogonin enhances intracellular adiponectin levels and suppresses adiponectin secretion in 3T3-L1 adipocytes. | 2017 | Endocr. J. | pmid:27667474 |
Yeh CH et al. | Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. | 2014 | Environ. Toxicol. | pmid:23362215 |
Wei CY et al. | Protective effect of wogonin on endotoxin-induced acute lung injury via reduction of p38 MAPK and JNK phosphorylation. | 2017 | Environ. Toxicol. | pmid:26892447 |
Huang FM et al. | BisGMA-induced cytotoxicity and genotoxicity in macrophages are attenuated by wogonin via reduction of intrinsic caspase pathway activation. | 2016 | Environ. Toxicol. | pmid:26756871 |
Sun HL et al. | Endotoxin-induced acute lung injury in mice is protected by 5,7-dihydroxy-8-methoxyflavone via inhibition of oxidative stress and HIF-1α. | 2016 | Environ. Toxicol. | pmid:26213241 |
Boozari M et al. | Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25546119 |
Li T et al. | Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. | 2011 | Eur J Drug Metab Pharmacokinet | pmid:21713461 |
Zhang Y et al. | The Influence of Compatibility of Rhubarb and Radix Scutellariae on the Pharmacokinetics of Anthraquinones and Flavonoids in Rat Plasma. | 2018 | Eur J Drug Metab Pharmacokinet | pmid:29134502 |
Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
Zhang F and Wang G | A review of non-nucleoside anti-hepatitis B virus agents. | 2014 | Eur J Med Chem | pmid:24549242 |
Wang J et al. | Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro. | 2017 | Eur J Med Chem | pmid:28987604 |
Sabra SA et al. | Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer. | 2018 | Eur J Pharm Biopharm | pmid:29689288 |
Shao YX et al. | The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. | 2012 | Eur. Biophys. J. | pmid:22228220 |
Ono K et al. | Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. | 1990 | Eur. J. Biochem. | pmid:1695572 |
Park HJ et al. | Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells. | 1998 | Eur. J. Cancer Prev. | pmid:9926295 |
Toton E et al. | The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. | 2012 | Eur. J. Pharmacol. | pmid:22381066 |
Wakabayashi I and Yasui K | Wogonin inhibits inducible prostaglandin E(2) production in macrophages. | 2000 | Eur. J. Pharmacol. | pmid:11040356 |
Son D et al. | Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. | 2004 | Eur. J. Pharmacol. | pmid:15189769 |