Wogonin

Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.

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Introduction

To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Wogonin?

Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Wogonin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Carcinoma D002277 18 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Brain Ischemia D002545 89 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Leukemia D007938 74 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Penile Induration D010411 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Sarcoma 180 D012510 21 associated lipids
Translocation, Genetic D014178 20 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Lymphoma, Large B-Cell, Diffuse D016403 13 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Papillomavirus Infections D030361 4 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Wogonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Wogonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Wogonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Wogonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Wogonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Wogonin

Download all related citations
Per page 10 20 50 100 | Total 475
Authors Title Published Journal PubMed Link
Kwak S et al. Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo. 2014 Toxicol. Appl. Pharmacol. pmid:25223693
Song X et al. Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. 2013 Toxicol. Appl. Pharmacol. pmid:23707765
Lee MY et al. A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats. 2011 Toxicol Int pmid:21976821
Yeh CH et al. Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. 2015 Toxicol Ind Health pmid:23592745
Yang DZ et al. Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. 2011 Talanta pmid:21726714
Petraglia AL et al. Stuck at the bench: Potential natural neuroprotective compounds for concussion. 2011 Surg Neurol Int pmid:22059141
Li J et al. Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. 2012 Spectrochim Acta A Mol Biomol Spectrosc pmid:22192416
Zhou YQ et al. [Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. 2013 Sichuan Da Xue Xue Bao Yi Xue Ban pmid:24490490
Ma X et al. [Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. 2012 Sheng Li Xue Bao pmid:22513472
Xu X et al. Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation. 2017 Sci Rep pmid:28150717
Khan NM et al. A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1β-induced activation of AP-1 in human OA chondrocytes. 2017 Sci Rep pmid:28256567
Katrahalli U et al. Interaction of bioactive coomassie brilliant blue g with protein: insights from spectroscopic methods. 2010 Oct-Dec Sci Pharm pmid:21179322
Zhao Q et al. A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. 2016 Sci Adv pmid:27152350
Zhao L et al. Developmental toxicity and genotoxicity studies of wogonin. 2011 Regul. Toxicol. Pharmacol. pmid:21459121
Ong ES et al. Proteomic analysis of mouse liver for the evaluation of effects of Scutellariae radix by liquid chromatography with tandem mass spectrometry. 2004 Rapid Commun. Mass Spectrom. pmid:15468106
Chi YS and Kim HP Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15589400
Chen CC et al. Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. 2012 PLoS ONE pmid:22272328
Chen XM et al. Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. 2013 PLoS ONE pmid:24265759
Yang C et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. 2011 PLoS ONE pmid:21779360
Zhao K et al. Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways. 2014 PLoS ONE pmid:25203554