Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Wogonin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lin YT et al. | Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. | 2003 | Biol. Pharm. Bull. | pmid:12736527 |
Zuo F et al. | Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats. | 2003 | Biol. Pharm. Bull. | pmid:12843610 |
Chi YS et al. | Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. | 2003 | Biochem. Pharmacol. | pmid:14505806 |
Wang Z et al. | Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells. | 2003 | BJU Int. | pmid:14616461 |
Pal M et al. | Antifungal activity of wogonin. | 2003 | Phytother Res | pmid:14669259 |
Lim BO et al. | Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12834292 |
Nagaki Y et al. | Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits. | 2003 May-Jun | Jpn. J. Ophthalmol. | pmid:12782159 |
Dao TT et al. | Synthesis and biological activities of 8-arylflavones. | 2004 | Arch. Pharm. Res. | pmid:15089030 |
Sonoda M et al. | Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. | 2004 | J Ethnopharmacol | pmid:15036470 |
Woźniak D et al. | Antimutagenic and antiradical properties of flavones from the roots of Scutellaria baicalensis georgi. | 2004 | Nahrung | pmid:15053344 |
Murch SJ et al. | A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds. | 2004 | Plant Cell Rep. | pmid:15449017 |
Scuro LS et al. | Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation. | 2004 | BMC Biochem. | pmid:15102332 |
Son D et al. | Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. | 2004 | Eur. J. Pharmacol. | pmid:15189769 |
Lim H et al. | Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, wogonin. | 2004 | Arch. Pharm. Res. | pmid:15180311 |
Park S et al. | Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. | 2004 | Dig. Dis. Sci. | pmid:15139485 |
Cho J and Lee HK | Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. | 2004 | Eur. J. Pharmacol. | pmid:14757129 |
Li HB et al. | Separation methods used for Scutellaria baicalensis active components. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15556504 |
Ong ES et al. | Proteomic analysis of mouse liver for the evaluation of effects of Scutellariae radix by liquid chromatography with tandem mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15468106 |
Chen TJ et al. | Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase. | 2004 | Toxicol. Lett. | pmid:14700523 |
Lim BO | Efficacy of wogonin in the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618621 |
Chaudhuri PK et al. | Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea. | 2004 | Phytother Res | pmid:15022161 |
Tian J et al. | Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA. | 2004 | J. Photochem. Photobiol. B, Biol. | pmid:15043845 |
Cho J and Lee HK | Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. | 2004 | Biol. Pharm. Bull. | pmid:15467195 |
Piao HZ et al. | Neuroprotective effect of wogonin: potential roles of inflammatory cytokines. | 2004 | Arch. Pharm. Res. | pmid:15473663 |
Tian J et al. | Interaction of wogonin with bovine serum albumin. | 2005 | Bioorg. Med. Chem. | pmid:15911327 |
Chuang HN et al. | Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line. | 2005 | Planta Med. | pmid:15931583 |
Tai MC et al. | Therapeutic potential of wogonin: a naturally occurring flavonoid. | 2005 | CNS Drug Rev | pmid:16007236 |
Li C et al. | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations. | 2005 | Biomed. Chromatogr. | pmid:15627280 |
Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
Aung H et al. | Scutellaria baicalensis decreases ritonavir-induced nausea. | 2005 | AIDS Res Ther | pmid:16368007 |
Dao TT et al. | Synthesis and iNOS inhibitory activities of thioflavones. | 2005 | Arch. Pharm. Res. | pmid:16042072 |
Hardeland R and Pandi-Perumal SR | Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug. | 2005 | Nutr Metab (Lond) | pmid:16153306 |
Bonham M et al. | Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. | 2005 | Clin. Cancer Res. | pmid:15897592 |
Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
Park EJ et al. | Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells. | 2005 | Planta Med. | pmid:16206047 |
Jang J et al. | Structure and antiinflammatory activity relationships of wogonin derivatives. | 2005 | Arch. Pharm. Res. | pmid:16178410 |
Han CK et al. | Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism. | 2005 | Biol. Pharm. Bull. | pmid:16079475 |
Ma Z et al. | Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. | 2005 | Blood | pmid:15626742 |
Goh D et al. | Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. | 2005 | J. Agric. Food Chem. | pmid:16218664 |
Li HB and Chen F | Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:15941045 |
Ohtake N et al. | The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation. | 2005 | Eur. J. Pharmacol. | pmid:15659321 |
Chun W et al. | Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity. | 2005 | Arch. Pharm. Res. | pmid:15789754 |
Chi YS and Kim HP | Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589400 |
Du CF et al. | [Studies on chemical constituents in bark of dictamnus dasycarpus]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16400943 |
Liu Y et al. | Binding of wogonin to human gammaglobulin. | 2005 | Int. J. Biol. Macromol. | pmid:16242767 |
Yu CS et al. | Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells. | 2005 Jan-Feb | Anticancer Res. | pmid:15816529 |
Pan MH et al. | Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. | 2006 | Biochem. Pharmacol. | pmid:16949556 |
Hu Y et al. | Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17069758 |
Zhang H et al. | Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive. | 2006 | J Chromatogr A | pmid:16952364 |
Kim YH et al. | Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16893689 |