Wogonin
Wogonin is a lipid of Polyketides (PK) class. Wogonin is associated with abnormalities such as Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and Ischemia. The involved functions are known as Inflammation, Regulation, luciferase activity, store-operated calcium entry and Transcriptional Activation. Wogonin often locates in Cytoplasmic matrix, Pore, Membrane, Protoplasm and Mitochondria. The associated genes with Wogonin are SGK1 gene, ORAI1 gene, STIM1 gene, P4HTM gene and BCL2 gene.
Cross Reference
Introduction
To understand associated biological information of Wogonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Wogonin?
Wogonin is suspected in Ischemia, Hyperlipidemia, Atherosclerosis, Inflammatory disorder, Dermatitis, Atopic and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Wogonin
PubChem Associated disorders and diseases
What pathways are associated with Wogonin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Wogonin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Wogonin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Wogonin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Wogonin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Wogonin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen SS et al. | Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. | 2012 | Discov Med | pmid:23200064 |
| Shao YX et al. | The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin. | 2012 | Eur. Biophys. J. | pmid:22228220 |
| Li J et al. | Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22192416 |
| Huang KF et al. | Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. | 2012 | Int. Immunopharmacol. | pmid:22182776 |
| Cheng J et al. | Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. | 2012 | Int J Nanomedicine | pmid:22745547 |
| He F et al. | Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species. | 2012 | Oncol. Rep. | pmid:22665077 |
| Shih HC and Yang LL | Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. | 2012 | Pharm Biol | pmid:22471999 |
| Ma X et al. | [Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. | 2012 | Sheng Li Xue Bao | pmid:22513472 |
| Wang L et al. | Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. | 2012 | Int J Nanomedicine | pmid:22359456 |
| Lin CM et al. | Functional role of wogonin in anti-angiogenesis. | 2012 | Am. J. Chin. Med. | pmid:22419433 |
| Lee DH et al. | Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. | 2012 | Cell. Signal. | pmid:22846543 |
| Yang Y et al. | Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. | 2012 | PLoS ONE | pmid:23251389 |
| Ci X et al. | Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. | 2012 | PLoS ONE | pmid:22563373 |
| Wang TC et al. | Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest. | 2012 | Evid Based Complement Alternat Med | pmid:22693529 |
| Xia B et al. | A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. | 2012 | Mol. Pharm. | pmid:23033922 |
| Chen H et al. | A new strategy for quality control and qualitative analysis of Yinhuang preparations by HPLC-DAD-MS/MS. | 2012 | Anal Bioanal Chem | pmid:22885972 |
| Hayasaka S et al. | Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review. | 2012 | Am. J. Chin. Med. | pmid:22928823 |
| Tsai CF et al. | Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. | 2012 | Int J Mol Sci | pmid:22949836 |
| Huan SK et al. | Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. | 2012 | Molecules | pmid:22634839 |
| Qi XF et al. | Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. | 2012 | Evid Based Complement Alternat Med | pmid:21785648 |
| Li HY et al. | Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFα. | 2012 | J. Biomed. Biotechnol. | pmid:22536016 |
| Koppula S et al. | Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease. | 2012 | Mediators Inflamm. | pmid:22577256 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Kim SJ et al. | Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. | 2012 | Mol Med Rep | pmid:22992837 |
| Im AR et al. | Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. | 2012 | Evid Based Complement Alternat Med | pmid:22969827 |
| Ding J et al. | Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. | 2012 | J. Biol. Chem. | pmid:22086925 |
| Zhu J et al. | Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis. | 2012 | PLoS ONE | pmid:22590504 |
| Kang SH et al. | Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. | 2012 | PLoS ONE | pmid:22493659 |
| Zhong Y et al. | Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response. | 2013 | Mol. Carcinog. | pmid:22593043 |
| Xu F et al. | The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. | 2013 | J Pharm Sci | pmid:24018852 |
| Oshima N et al. | Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1. | 2013 | J Nat Med | pmid:22729955 |
| Yu C et al. | Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. | 2013 | Pharm Biol | pmid:23738852 |
| Wang Y et al. | GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin. | 2013 | Toxicol. Lett. | pmid:23872260 |
| Zhao L et al. | Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. | 2013 | Biochem. Cell Biol. | pmid:23859016 |
| Wang F et al. | Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1. | 2013 | Toxicology | pmid:23246481 |
| Kimura Y and Sumiyoshi M | Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. | 2013 | Phytomedicine | pmid:23219337 |
| Wang CZ et al. | Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. | 2013 | Int. J. Oncol. | pmid:23337959 |
| Yang L et al. | Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. | 2013 | Apoptosis | pmid:23371323 |
| Song X et al. | Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23707765 |
| Zhang M et al. | Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax. | 2013 | Life Sci. | pmid:23142241 |
| Chengcheng G et al. | Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin. | 2013 | Afr Health Sci | pmid:24250287 |
| Chen XM et al. | Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. | 2013 | PLoS ONE | pmid:24265759 |
| He L et al. | Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. | 2013 | Toxicology | pmid:23907061 |
| Chirumbolo S | Anticancer properties of the flavone wogonin. | 2013 | Toxicology | pmid:23994129 |
| Zhou YQ et al. | [Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity]. | 2013 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:24490490 |
| Kim MS et al. | Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. | 2013 | Cell Biol. Toxicol. | pmid:23955116 |
| Attia SM et al. | Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. | 2013 | Food Chem. Toxicol. | pmid:23872129 |
| Kim SG et al. | Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas. | 2013 | J Nat Med | pmid:22855402 |
| Kim TW et al. | Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity. | 2013 | Planta Med. | pmid:23818268 |
| Lin CC et al. | Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells. | 2013 Nov-Dec | In Vivo | pmid:24292576 |